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315 results for “Cortisol”
Revisiting peak serum cortisol response to insulin-induced hypoglycemia in children and adolescents
<p>Purpose: To evaluate factors that could potentially affect the hypothalamic-pituitary adrenal (HPA) axis response to insulin-induced hypoglycemia in children without history or symptoms of adrenal insufficiency and to propose a cut-off value to define a normal response in this population. Methods: Exploratory single-centre study involving 78 children that prospectively underwent insulin tolerance test (ITT) for suspected growth hormone (GH) deficiency. Methods: Glucose, cortisol, GH, adrenocorticotropic hormone (ACTH), epinephrine and norepinephrine levels were measured at baseline and after insulin-induced hypoglycemia. Serum cortisol was measured using Access automated immunoassay. Results: Mean (range) basal morning serum cortisol of 8 (2.2-19.5) µg/dL/ 222 (61-542) nmol/L increased after hypoglycemia to 20.5 (14.6-29.5) µg/dL / 570 nmol/L (405 -819) nmol/L. Peak serum cortisol levels of 14.6 µg/dL (405nmol/L) and 15.4 µg/dL (428 nmol/L) corresponded to the 2.5<sup>th</sup> and 5<sup>th</sup> percentiles, respectively. Peak serum cortisol correlated with peak plasma epinephrine (r = 0.367; <em>P</em> = 0.0014) but did not correlate with age, BMI-SD or peak serum GH. Children with intact and abnormal GH responses presented similar mean peak serum cortisol levels (20.0 vs. 20.6 µg/dL / 555 vs. 572 nmol/L; <em>P</em> = 0.21). Conclusion: Our data indicate that the current cut-off to define normal HPA axis response in children after insulin-induced hypoglycemia warrants reevaluation in order to avoid overdiagnosis of adrenal insufficiency. Our results suggest that peak serum cortisol levels ³ 15.4 µg/dL (428 nmol/L) in children undergoing ITT might represent a normal cortisol response to stress, regardless of age, BMI or GH secretory capacity.</p>
Effect of Acute Sleep Hygiene on Salivary Cortisol Level Following A Late Night Soccer-Specific Training Session
<p>Letter to the editor with data, no abstract available</p>
Data from: Early maternal loss affects diurnal cortisol slopes in immature but not mature wild chimpanzees
<p>Biological embedding of stress experienced early in life is a mechanism proposed to explain the fitness costs of maternal loss in mammals. This embedding is expected to lead to long-term alterations of the hypothalamic pituitary adrenal (HPA) axis activity. This idea has, however, rarely been tested in wild long-lived animals. We assessed whether, as in humans, maternal loss had short and long-term impacts on orphan wild chimpanzee urinary cortisol levels and diurnal urinary cortisol slopes, both indicative of the HPA axis functioning. Immature orphan chimpanzees who experienced early maternal loss had diurnal cortisol slopes indicative of high activation of the HPA axis and recently orphaned immatures had elevated cortisol levels. However, unlike in humans, the cortisol profiles did not differ between orphan and non-orphan adult male chimpanzees. Our study highlights that long-term alteration of stress physiology related to early life adversity may not be viable in some wild animal populations. </p>
Data from: Fecal cortisol metabolites to assess stress in wildlife: evaluation of a field method in free ranging chamois
1. Non-invasive faecal cortisol metabolite (FCM) analysis is a well-established tool to quantify stress in captive and free-ranging species. While the method has great potential, its suitability in field studies might be limited when faecal samples from unknown individuals are used. Possible factors affecting final results and thus jeopardizing correct data interpretation are individual and sex-specific variation, storage conditions and uneven distribution of metabolites in the faeces. 2. We tested these factors on a population of free-ranging Alpine chamois Rupicapra rupicapra rupicapra in the Austrian Alps. Faecal samples (n = 183) were analysed with an established enzyme immunoassay (EIA). To further validate the assay for FCM in chamois, a high-performance liquid chromatography (HPLC) was performed. Sex-specific differences in metabolite excretion were evaluated. Effects of storage length and temperature on FCM were tested with two experiments. The distribution of metabolites in the faeces was determined by the analysis of subsamples of single faecal samples. Potential individual effects on FCM levels and individually variable reactions to stressful events were evaluated with a simulation experiment. 3. Patterns of immunoreactive peaks after HPLC separation were similar for different faecal samples, except in one sample of a male. In the stability tests, storage time at ambient temperature prior to freezing and the individual were the most important variables in modulating FCM. Concentrations within single samples varied significantly between pellets. Analysis of faecal samples collected from June to October showed a highly significant seasonal trend (P < 0·001) and a considerable variance of FCM levels within the population. Simulations confirmed that individual reactions to stressors in terms of varying gradients and FCM levels can explain the observed FCM patterns. 4. Using FCM to assess adrenocortical function requires measuring extensively metabolized products of glucocorticoids, whose excretion and detection in faeces depend on several environmental, endogenous and methodological factors. In free-ranging wildlife, these factors and the intrinsic individual differences in FCM excretion generate systemic noise and substantially distort final results. Therefore, sampling of unknown individuals inevitably jeopardizes meaningful interpretation of data, if the above named factors are not taken into consideration.
Fig. 3 in 17,20β-P and cortisol are the main in vitro metabolites of 17-hydroxyprogesterone produced by spermiating testes of Micropogonias furnieri (Desmarest, 1823) (Perciformes: Sciaenidae)
Fig. 3. Analysis of zone C of TLC or di-hydroxylated progestins area (see Fig. 1) by HPLC using methanol/acetonitrile/water 33/26/41 v/v/v (system III) in Micropogonias furnieri.
Fig. 4 in 17,20β-P and cortisol are the main in vitro metabolites of 17-hydroxyprogesterone produced by spermiating testes of Micropogonias furnieri (Desmarest, 1823) (Perciformes: Sciaenidae)
Fig. 4. Plasma level of 17,20ss-P in males at different stages of development sampled at the Río de la Plata estuary. 1: Immaturetestis; 2: Developingtestis (earlyspermatogenesis); 3: Fully developed testis (whole spermatogenesis), 4: Spermiating testis; 6: Resting testis. n = number of fish collected for each stage.
Fig. 2 in 17,20β-P and cortisol are the main in vitro metabolites of 17-hydroxyprogesterone produced by spermiating testes of Micropogonias furnieri (Desmarest, 1823) (Perciformes: Sciaenidae)
Fig. 2. Analysis of zone B of TLC or cortisol area (see Fig. 1) by HPLC using methanol/acetonitrile/water 33/26/41 v/v/v (system III) in Micropogonias furnieri.
Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications".
<p>Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications</p> <p>Chakavak Esmaeili1, Štěpán Stehlík2, Martin Krejci3, Bohuslav Rezek1</p> <p>1 Faculty of Electrical Engineering, CTU in Prague, Technicka 2, 16627 Prague, Czech Republic</p> <p>2 Institute of Physics of the Czech Academy of Sciences, Cukrovarnická 10, 162 00 Prague, Czech Republic</p> <p>3 FHNW University of Applied Sciences and Arts Northwestern Switzerland School of Engineering Klosterzelgstrasse 2<br>CH-5210 Windisch</p> <p> </p> <p>Fig 1A. SEM images of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-O<br>Fig 1B. SEM image of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-H<br>Fig 1C. SEM micrographs of (a) bare carbon electrode, (b) SPE/HPHT-O, (c) SPE/HPHT-O/APTES, (d) SPE/HPHT-O/APTES/EDC NHS, (e) SPE/HPHT-O/APTES/EDC NHS/Ab, (f) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA, (g) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag (with original magnification 2.00KX (up) and 15.00KX (down) at 5 kV)<br>Fig 2. The preparation and immobilization step of the cortisol fabrication based on electrochemical immunosensor <br>Fig 3. Functionalization step. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/EDC NHS, at pH 7.0, containing 250 mM KCl and 5 mM K3[Fe(CN)6] and 5 mM K4[Fe(CN)6], Scan rate 0.1Vs−1<br>Fig 4. Sensing steps. a) CV and b) DPV results for (4) electrode/HPHT-O/APTES/EDC NHS, (5) electrode/HPHT-O/APTES/EDC NHS/Ab, (6) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 5. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/Ab, (5) electrode/HPHT-O/APTES/Ab/BSA, and (6) electrode/HPHT-O/APTES /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 6. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/EDC NHS, (4) electrode/HPHT-O/ EDC NHS /Ab, (5) electrode/HPHT-O/ EDC NHS /Ab/BSA, and (6) electrode/HPHT-O/ EDC NHS /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 7. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/EDC NHS, (5) electrode/HPHT-H/APTES/EDC NHS/Ab, (6) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 8. Variation of the immunosensor response against the cortisol concentrations in the range of 1.0 ng to 0.5 ng/mL at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 9. Interference study involving progesterone (2430 pg/ml), β-oestradiol (32 pg/ml), cortisone (28.6 nM), and corticosterone (3.94 nM) with respect to cortisol (1 ng/mL)</p> <p><br>Fig S1. Optical images obtained for (a) before and (b) after rinsing of 3.0µg HPHT-H<br>Fig S2. Optical images obtained for (a) bare carbon electrode, (b) HPHT-O, (c) HPHT-O/APTES, (d) HPHT-O/APTES/EDC NHS, (e) HPHT-O/APTES/EDC NHS /Ab, (f) HPHT-O/APTES/EDC NHS /Ab/BSA, (g) HPHT-O/APTES/EDC NHS /Ab/BSA/Ag<br>Fig S3. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/Ab, (5) electrode/HPHT-H/APTES/ Ab/BSA, and (6) electrode/HPHT-H/APTES/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S4. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/EDC NHS, (4) electrode/HPHT-H/EDC NHS/Ab, (5) electrode/HPHT-H/EDC NHS/ Ab/BSA, and (6) electrode/HPHT-H/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S5. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/APTES, (3) electrode/APTES/EDC NHS, (4) electrode/APTES/EDC NHS/Ab, (5) electrode/APTES/EDC NHS/Ab /BSA, and (6) electrode/APTES/EDC NHS/Ab/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S</p> <p> </p> <p><br>Table 1. Summary of the DPV electrochemical performance of the HPHT-O modified electrode using APTES and EDC-NHS as crosslinkers in cortisol immunosensor detection<br>Table 2. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing APTES without EDC-NHS as a crosslinker in cortisol immunosensor detection.<br>Table 3. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing EDC-NHS without APTES as a crosslinker in cortisol immunosensor detection<br>Table 4. Determination of cortisol in artificial human saliva.</p>
Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Acute Pancreatitis
ClinicalTrials.gov study NCT03830060. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Cohort Study of Adrenogenic Autonomic Cortisol Secretion
ClinicalTrials.gov study NCT05743933. IPD Sharing: UNDECIDED. Countries: 0. Publications: 3.
The Effect of Music Played to Liver Transplant Donors During Surgery on Some Hemodynamic Values and Cortisol Levels
ClinicalTrials.gov study NCT06997237. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of the Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas
ClinicalTrials.gov study NCT04308590. IPD Sharing: NO. Countries: 9. Publications: 0.
Thyroid and Cortisol Hormone Response to Sepsis
ClinicalTrials.gov study NCT06289179. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Hair Cortisol and Testosterone Levels in Patients With Sarcoidosis
ClinicalTrials.gov study NCT03108547. IPD Sharing: NO. Countries: 0. Publications: 1.
Effect of Nursing Interventions on Pain and Salivary Cortisol Levels During Heel Stick in Preterm Newborns
ClinicalTrials.gov study NCT06628232. IPD Sharing: NO. Countries: 0. Publications: 2.
Effects of Surgery Start Time on Postoperative Interleukin-6, Interleukin-8, and Cortisol
ClinicalTrials.gov study NCT03076827. IPD Sharing: YES. Countries: 0. Publications: 2.
Effect of Maternal Cortisol Levels on Fetal Heart Rate Patterns
ClinicalTrials.gov study NCT05503433. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Eszopiclone Treatment & Cortisol Responsivity
ClinicalTrials.gov study NCT00889200. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Rapid Cortisol Assay in Adrenal Vein Sampling
ClinicalTrials.gov study NCT03449797. IPD Sharing: NO. Countries: 0. Publications: 16.
A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertensio
ClinicalTrials.gov study NCT06336356. IPD Sharing: YES. Countries: 1. Publications: 0.
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