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613 results for “Dengue”
FIGURE 2 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 2. Portuguese Aedes albopictus females seeking human blood. Note characteristic scutal white stripe, distinct silvery-white scales on the maxillary palpi and tarsi, as well as narrow scales over the wing root and silvery-white basolateral abdominal tergal markings.
FIGURE 1 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 1. Distribution of Aedes albopictus in the Iberian Península. In green, distribution in Spain according to Collantes et al. (2016). In red, highlighted by arrow, new occurrence in Portugal.
FIGURE 3 in The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae)
FIGURE 3. Biting activity of Ae. albopictus assessed by human-bait catches. Specimens arriving to bite were captured every 15 minutes to avoid recapture. The x axis is a timeline of 15-minute intervals; the y axis is an average of the three days of sampling.
Assessment of a multiplex PCR and Nanopore-based method for portable dengue virus sequencing in Indonesia
<p>Multiplex primer sets for amplification of the complete coding region of Indonesian dengue virus.</p>
Full dataset for dengue forecasting in Brazil for Infodengue-Mosqlimate sprint 2024
<p><span>The year 2024 has seen an exceptional number of reported dengue fever cases in various parts of the world. In Brazil, the disease has spread to areas in the south and at altitudes where epidemics were not previously recorded, and the incidence rate has far exceeded that of previous years. The objective of this dataset is to promote, in a standardized way, the training of predictive models with the aim of developing forecast models for dengue in Brazil.</span></p>
An open access dataset of reported Dengue outbreaks in Italy
<p><strong>Italian Dengue data</strong></p> <p><a href="https://www.epicentro.iss.it/arbovirosi/bollettini">Sito dell'Istituto Superiore di Sanità - Sistema nazionale di sorveglianza delle arbovirosi: i bollettini periodici</a></p> <p>Arboviral diseases are caused by viral agents carried by arthropod insects, such as mosquitoes, ticks and phlebotomas, through their bite or sting. Currently, more than 100 viruses associated with arboviruses have been identified that are capable of causing disorders in human health. The majority of these viruses belong to families and groups such as the <em>Togaviridae</em> (Alphavirus), the <em>Flaviridae</em> (Flavivirus) and the <em>Bunyaviridae</em> (Bunyavirus and Phlebovirus). In Italy, arboviral infections may arise from both imported and autochthonous cases and may present with diverse clinical symptoms. Surveillance of arboviruses is coordinated by the Istituto Superiore di Sanità (ISS) and, in the case of West Nile and Usutu virus surveillance, by the Istituto Zooprofilattico dell'Abruzzo e del Molise (Izs-AM), in collaboration with the Ministry of Health, which periodically publishes Surveillance and Response Plans to ensure early detection of cases and to reduce any spread as far as possible. Epidemiological surveillance is regulated by the "<a href="https://www.salute.gov.it/imgs/C_17_pubblicazioni_2947_allegato.pdf#page=8.08">National Plan for Prevention, Surveillance and Response to Arboviruses (PNA) 2020-2025</a>".</p> <p>In order to inform citizens and make the collected data available, which is only useful for communication and information purposes, the following information is made available under the CC-BY-4.0 licence</p> <p>- National evolution data<br>- Regional data<br>- Summary bulletins</p> <p><strong>Repository structure</strong><br>```<br>dengue/<br>│<br>├── */<br>│ ├── bulletins/<br>│ │ ├── Dengue_*.pdf<br>│ │ ├── ...<br>│ ├── surveillance/<br>│ │ ├── 2023/<br>│ │ │ ├── dengue-ita-*.csv<br>│ │ │ ├── dengue-ita-age-*.csv<br>│ │ │ ├── dengue-ita-location-exposure-*.csv<br>│ │ │ ├── dengue-ita-regions-*.csv<br>│ │ ├── ...<br>│ │ │ ├── ...<br>│ ├── dengue-ita-summary-cases.csv<br>│ ├── dengue-ita-summary-cases-regions.csv</p> <p>```</p> <p><strong>Data structure</strong></p> <p>- <a href="https://github.com/fbranda/dengue/blob/main/dati-andamento-dengue-italia.md">Evoulution data about Dengue Italy (IT)</a></p> <p><strong>Example of data use</strong></p> <p>Direct download (CSV): https://raw.githubusercontent.com/fbranda/dengue/main/surveillance/dengue-ita-2023.csv</p> <p>Python (requires `pandas`):<br>```python<br>import pandas as pd<br>df = pd.read_csv("https://raw.githubusercontent.com/fbranda/dengue/main/surveillance/dengue-ita-2023.csv")<br>```</p> <p>R (requires `httr`):<br>```r<br>library(httr)<br>df <- read.csv(text=content(GET("https://raw.githubusercontent.com/fbranda/dengue/main/surveillance/dengue-ita-2023.csv")))<br>```</p>
Data from: Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for Dengue virus replication
Dengue virus (DENV) causes the most prevalent arthropod-borne viral disease in humans. Although Aedes mosquitoes transmit DENV when probing for blood in the skin, no information exists on DENV infection and immune response in the dermis, where the blood vessels are found. DENV suppresses the interferon response, replicates, and causes disease in humans but not wild-type mice. Here, we used mice lacking the interferon-α/β receptor (Ifnar–/–), which had normal cell populations in the skin and were susceptible to intradermal DENV infection, to investigate the dynamics of early DENV infection of immune cells in the skin. CD103+ classical dendritic cells (cDCs), Ly6C– CD11b+ cDCs, and macrophages in the steady-state dermis were initial targets of DENV infection 12-24 hours post-inoculation but then decreased in frequency. We demonstrated recruitment of adoptively-transferred Ly6Chigh monocytes from wild-type and Ifnar–/– origin to the DENV-infected dermis and differentiation to Ly6C+ CD11b+ monocyte-derived DCs (moDCs), which became DENV-infected after 48 hours, and were then the major targets for virus replication. Ly6Chigh monocytes that entered the DENV-infected dermis expressed chemokine receptor CCR2, likely mediating recruitment. Further, we show that ~100-fold more hematopoietic cells in the dermis were DENV-infected compared to Langerhans cells in the epidermis. Overall, these results identify the dermis as the main site of early DENV replication and show that DENV infection in the skin occurs in two waves: initial infection of resident cDCs and macrophages, followed by infection of monocytes and moDCs that are recruited to the dermis. Our study reveals a novel viral strategy of exploiting monocyte recruitment to increase the number of targets for infection at the site of invasion in the skin and highlights the skin as a potential site for therapeutic action or intradermal vaccination.
Fig. 8 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 8. (a) The general structure of a flavonoid. (b) Chemical structures of the flavonoids – quercetin (14), kaempferol-3-O-rutinoside (16), rutin (17), hyperoside (18), the chromanone derivative (20), myricetin (23), apigenin (24), and luteolin (25), (c) pongamol (15), (d) epicatechin (19), catechin (27), EGCG (29), hesperetin (32), and hesperidin (33), (e) amentoflavone (21), (f) curcumin (22), (g) delphinidin (26), and (h) rotenone (30).
Fig. 1 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 1. An illustration of dengue virus structure showing the lipid bilayer, the structural proteins, and the positive RNA strand.
Fig. 7 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 7. Chemical structures of ganodermanontriol (10), lucidumol A (11), ganoderic acid C2 (12), and ganosporeric acid A (13). Wherein, () indicates a wedged bond; (- - -) indicates a hashed bond.
Fig. 9 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 9. Chemical structures of the phenolic compounds (a) gallic acid (31), methyl orsellinate (34), resveratrol (35), gingerol (36), anacardic acid (37), and cardol triene (38), (b) tatanan A (39).
Fig. 2 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 2. Flavivirus life cycle since its binding to the host's mannose-binding receptor (MR) and/or the dendritic cell-specific intercellular adhesion molecule-3- grabbing non-integrin (DC-SIGN) receptor, and the cleavage of the translated polyprotein into the structural (C; capsid, M; membrane, and E; envelope) and the non-structural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5).
Fig. 3 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 3. Chemical structures of the fatty acids (a) oleic acid (1), (b) stearic acid (2), and (c) palmitic acid (3).
Fig. 4 in Recent advances in natural products as potential inhibitors of dengue virus with a special emphasis on NS2b/NS3 protease
Fig. 4. Chemical structures of the glucosides (a) isobiflorin (4), biflorin (5), and (b) eugeniin (6).
Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial
ClinicalTrials.gov study NCT06121934. IPD Sharing: YES. Countries: 1. Publications: 4.
Tetravalent Chimeric Dengue Vaccine Trial
ClinicalTrials.gov study NCT01110551. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluating the Safety and Immune Response to Two Admixtures of a Tetravalent Dengue Virus Vaccine
ClinicalTrials.gov study NCT01436422. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Two-dose Primary Vaccination Study of a Tetravalent Dengue Virus Purified Inactivated Vaccine vs. Placebo in Healthy Adults (in Puerto Rico)
ClinicalTrials.gov study NCT01702857. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical and Laboratory Factors for the Progression of Severe Dengue Among Hospitalized Patients During an Upsurge
ClinicalTrials.gov study NCT06697041. IPD Sharing: NO. Countries: 1. Publications: 8.
Study of Febrile Illness for Dengue-Endemic Areas in Latin America
ClinicalTrials.gov study NCT01293331. IPD Sharing: Not stated. Countries: 4. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.