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207 results for “Huntingtin”
ROS-Specific Huntingtin Interactions: Mass spec analysis of MMS-treated mouse striatal cells
<p>Mass spec identification of DNA damage-specific huntingtin protein-protein interactions. </p>
ROS-Specific Huntingtin Interactions: Reproducible high and medium confidence huntingtin interacting proteins
<p>Mass spec identification of DNA damage-specific huntingtin protein-protein interactions.</p>
ROS-Specific Huntingtin Interactions: Measuring poly ADP ribose levels in HD cells
<p>Comparison of poly ADP ribose levels in HD cells versus controls in response to ROS.</p>
ROS-Specific Huntingtin Interactions: huntingtin 1-586 chromatin retention assay with veliparib
<p>Testing chromatin retention of huntingtin fragment 1-586 upon PARP inhibition.</p>
ROS-Specific Huntingtin Interactions: Optimization of Poly ADP Ribose Detection by Immunofluorescence
<p>Optimization of conditions for the detection of poly ADP ribose by immunofluorescence.</p>
Preliminary experiments to assess the suitability of DLS for protein interaction studies with huntingtin-HAP40 2019/08/12
<p><strong>Project: </strong>Biophysical investigation of the HTT interactome</p> <p><strong>Experiment: </strong>Preliminary experiments to assess the suitability of DLS for protein interaction studies with huntingtin-HAP40</p> <p><strong>Date completed:­ </strong>2019/08/12</p> <p><strong>Rationale: </strong>HTT is a multi-valent protein interactor and scaffold. It is likely that many of the proteins HTT interacts with form weak or transient interactions. One method which may be fruitful to detect this type of interaction is dynamic light scattering – a method which allows in solution calculation of protein particle radius. HTT-HAP40 Q23 (<a href="https://zenodo.org/record/3383265">https://zenodo.org/record/3383265</a>), PACSIN1 (<a href="https://zenodo.org/record/3256589">https://zenodo.org/record/3256589</a>) and PFN1A (kindly donated by Opher Gileadi and Tracy Keates) were analysed in a dilution series by DLS to assess signal to noise and concentration dependency of protein radius and polydispersity. </p>
iMagemHTT: FIH Evaluation of Novel Mutant Huntingtin PET Radioligands [¹¹C]CHDI-00485180-R and [¹¹C]CHDI-00485626
ClinicalTrials.gov study NCT03810898. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ROS-Specific Huntingtin Interactions: Testing PARG activity in HD patient fibroblasts round 2
<p>Comparison nuclear PAR levels in wild type and HD (TruHD) fibroblasts in response to a PARG inhibitor concentration gradient (as a measure of PARG activity).</p>
Large scale expression and purification of full length huntingtin Q23 from baculovirus expression system (2016/08/29)
<p>Open lab notebook huntingtin structure function project.<br> </p>
Expression and purification of huntingtin domain constructs spanning aa. P80-G428 (2016/11/29)
<p>Open lab notebook huntingtin structure function project.<br> </p>
ROS-specific Huntingtin Interactions: Oxidative Stress Optimization 3NP
<p>Optimization step in the lead up to mass spec identification of ROS-specific huntingtin protein-protein interactions.</p>
ROS-Specific Huntingtin Interactions: Testing PARP activity in HD patient fibroblasts
<p>Comparison of nuclear PAR levels in wild type and HD (TruHD) fibroblasts in response to a PARP inhibitor concentration gradient (as a measure of PARP activity).</p>
Differential static light scattering (DSLS) of huntingtin-HAP40 complex samples of different polyQ lengths (Q23 and Q54) – 2018/10/13
<p>Project - Huntingtin structure-function open lab notebook. </p> <p>Experiment - Differential static light scattering (DSLS) of huntingtin-HAP40 complex samples of different polyQ lengths (Q23 and Q54) - 2018/10/13. To investigate how increased polyQ length of the huntingtin protein and complex formation of HAP40 might affect thermal aggregation properties of the samples. </p>
Large scale expression and purification of full-length huntingtin Q54 with HAP40 from baculoviral expression system production in sf9 insect cells – 2018/08/04
<p><strong>Project</strong> - Huntingtin structure-function open lab notebook. </p> <p><strong>Rationale </strong>- Purified huntingtin samples with and without stabilising binding partners (HAP40) are required for use in structural and functional studies, in particular SAXS experiments. </p>
A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers
ClinicalTrials.gov study NCT05509153. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
N- Homocysteinylated Huntingtin in Huntington's Disease
ClinicalTrials.gov study NCT05225051. IPD Sharing: NO. Countries: 0. Publications: 2.
Data from: Abnormal brain development in child and adolescent carriers of mutant huntingtin
Open the record for dataset details and reuse information.
A genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity
GEO Series GSE166567. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Mutant Huntingtin promotes neuronal death through cell autonomous microglial activation via myeloid lineage- determining factors
GEO Series GSE54443. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Small molecule activation of a pseudoexon triggers huntingtin-lowering (RNA-Seq)
GEO Series GSE162813. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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