Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
684
datasets available to search
ShareScore release 0.9.0
Dataset results
684 results for “Influenza A virus”
Data from: The contrasting phylodynamics of human influenza B viruses
Open the record for dataset details and reuse information.
Data from: Subtype diversity and reassortment potential for co-circulating avian influenza viruses at a diversity hot spot
Open the record for dataset details and reuse information.
Data from: Global circulation patterns of seasonal influenza viruses vary with antigenic drift
Open the record for dataset details and reuse information.
Information and sequences of the six lineages identified in the H1N1 influenza A virus
Open the record for dataset details and reuse information.
A pharmacoeconomic study of post-exposure prophylaxis strategies for influenza virus infections in Japan
Open the record for dataset details and reuse information.
Data from: Pharmacoeconomic study of anti-influenza virus drugs in Japan based on a network meta-analysis
Open the record for dataset details and reuse information.
Data from: Range-wide genetic population structure of common pochard (Aythya ferina): a potentially important vector of highly pathogenic avian influenza viruses
Open the record for dataset details and reuse information.
Raw diffraction data from Acta Cryst. 2020, D76, 1057-1065 (Wuhan Asiatic toad influenza virus neuraminidase with lattice-translocation defects)
<p>The ectodomain (residues 79–466) of the neuraminidase from the Wuhan Asiatic toad influenza virus (GenBank accession No. MG600049.1) was crystallized. X-ray diffraction data were collected on beamline BL17U1 at Shanghai Synchrotron Radiation Facility (SSRF) using a Dectris EIGER 16M detector. A total of 100 frames were recorded with an oscillation angle of 1.0 deg. Sharp–diffuse diffraction patterns and native Patterson peaks manifest the pathological imperfection: lattice-translocation defects.</p> <p> </p>
Data from: Individual correlates of infectivity of influenza A virus infections in households
Background: Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. Methods: In a detailed study of influenza virus transmission within households in 2008–12, we recruited index cases with confirmed influenza infection from outpatient clinics, and followed up their household contacts for 7–10 days to identify secondary infections. We used individual-based hazard models to characterize the relationship between individual viral shedding and individual infectivity. Results: We analyzed 386 households with 1147 household contacts. Index cases were separated into 3 groups according to their estimated level of viral shedding at symptom onset. We did not find a statistically significant association of virus shedding with transmission. Index cases in medium and higher viral shedding groups were estimated to have 21% (95% CI: -29%, 113%) and 44% (CI: -16%, 167%) higher infectivity, compared with those in the lower viral shedding group. Conclusions: Individual viral load measured by RT-PCR in the nose and throat was at most weakly correlated with individual infectivity in households. Other correlates of infectivity should be examined in future studies.
Data from: Pathobiological features favoring the intercontinental dissemination of highly pathogenic avian influenza virus
Avian influenza viruses (AIV) are a continued threat to global health and economy. Unlike other highly pathogenic AIV, novel H5N8 disseminated very quickly from Korea to other areas in Asia, Europe, and even North America following its first outbreak in 2014. However, the pathobiological features of the virus that favored its global translocation remain unknown. In this study, we used a compartmental model to examine the avian epidemiological characteristics that would support the geographic spread of influenza by bird migration, and to provide recommendations for AIV surveillance in wild bird populations. We simulated virus transmission and translocation in a migratory bird population while varying four system properties: 1) contact transmission rate; 2) infection recovery rate; 3) mortality rate induced by infection; and 4) migratory recovery rate. Using these simulations, we then calculated extinction and translocation probabilities for influenza during spring migration as a function of the altered properties. We find that lower infection recovery rates increase the likelihood of AIV translocation in migratory bird populations. In addition, lower mortality rates or migration recovery rates also favor translocation. Our results identify pathobiological features supporting AIV intercontinental dissemination risk and suggest that characteristic differences exist among H5N8 and other AIV subtypes that have not translocated as rapidly (e.g. H5N6 and H5N1).
Data from: Challenging the conceptual framework of maintenance hosts for influenza A viruses in wild birds
1.The conceptual framework considering Anseriformes and Charadriiformes as the main maintenance hosts for influenza A viruses (IAV) in wild birds has shaped IAV research and surveillance over the last decades. 2.We challenge this framework by reviewing the worldwide surveillance data on non-Anseriformes and non-Charadriiformes (NANC) species, generally considered as playing little role in IAV maintenance, available in literature and online data bases (close to 200 sources). 3.Globally, we found an IAV infection rate of 1.51% (95% CI, 1.44%–1.59%) for c.101 000 birds tested from NANC species. If Anseriformes have, as expected, a higher infection rate than any other bird orders, eight bird orders have an infection rate higher or close to the Charadriiformes infection rate, challenging the status of Charadriiformes. 4.We interpret the attention paid in favour of Charadriiformes by an extrapolation bias from data collected in hotspots of IAV infection in Charadriiformes (e.g. Delaware Bay, USA). 5.The growing data on IAV in wild birds worldwide, summarised here, supports two non-exclusive hypotheses: (i) the quality of the diagnostic tools and techniques used explain the patterns observed; (ii) IAV maintenance is determined by complex multi-host systems composed of multiple bird species, dependent on the ecosystem and its bird diversity and composition. 6.Synthesis and applications. Our results have two main implications. First, new research and surveillance should be designed in order to understand influenza A viruses ecology in wild birds across the world, along with appropriate diagnostic tools and new hypotheses and dedicated protocols. This should be done in line with our new conceptual framework that conveys less a priori than its predecessor. Secondly, our results call for more bridging between biological and epidemiological sciences in order to tackle disease ecology in multi-host systems.
Data from: Genome-wide evolutionary dynamics of influenza B viruses on a global scale
The global-scale epidemiology and genome-wide evolutionary dynamics of influenza B remain poorly understood compared with influenza A viruses. We compiled a spatio-temporally comprehensive dataset of influenza B viruses, comprising over 2,500 genomes sampled worldwide between 1987 and 2015, including 382 newly-sequenced genomes that fill substantial gaps in previous molecular surveillance studies. Our contributed data increase the number of available influenza B virus genomes in Europe, Africa and Central Asia, improving the global context to study influenza B viruses. We reveal Yamagata-lineage diversity results from co-circulation of two antigenically-distinct groups that also segregate genetically across the entire genome, without evidence of intra-lineage reassortment. In contrast, Victoria-lineage diversity stems from geographic segregation of different genetic clades, with variability in the degree of geographic spread among clades. Differences between the lineages are reflected in their antigenic dynamics, as Yamagata-lineage viruses show alternating dominance between antigenic groups, while Victoria-lineage viruses show antigenic drift of a single lineage. Structural mapping of amino acid substitutions on trunk branches of influenza B gene phylogenies further supports these antigenic differences and highlights two potential mechanisms of adaptation for polymerase activity. Our study provides new insights into the epidemiological and molecular processes shaping influenza B virus evolution globally.
Data from: Label-free sensitive detection of influenza virus using PZT discs with a synthetic sialylglycopolymer receptor layer
We describe rapid, label-free detection of Influenza A viruses using the first radial mode of oscillations of lead zirconate titanate (PZT) piezoelectric disks with a 2-mm radius and 100-µm thickness fabricated from a piezoelectric membrane. The disks are modified with a synthetic sialylglycopolymer receptor layer,and the coated disks are inserted in a flowing virus suspension. Label-free detection of the virus is achieved by monitoring the disk radial mode resonance frequency shift. Piezo transducers with sialylglycopolymer sensor layers exhibited a long lifetime, a high sensitivity, and the possibility of regeneration. We demonstrate positive, label-free detection of Influenza A viruses at concentrations below 10^5 virus particles per millilitre. We show that label-free, selective, sensitive detection of Influenza viruses by home appliances is possible in principle.
Data from: Ecosystem interactions underlie the spread of avian influenza A viruses with pandemic potential
Despite evidence for avian influenza A virus (AIV) transmission between wild and domestic ecosystems, the roles of bird migration and poultry trade in the spread of viruses remain enigmatic. In this study we integrate ecosystem interactions into a phylogeographic model to assess the contribution of wild and domestic hosts to AIV distribution and persistence. Analysis of globally sampled AIV datasets shows frequent two-way transmission between wild and domestic ecosystems. In general, viral flow from domestic to wild bird populations was restricted to within a geographic region. In contrast, spillover from wild to domestic populations occurred both within and between regions. Wild birds mediated long-distance dispersal at intercontinental scales whereas viral spread among poultry populations was a major driver of regional spread. Viral spread between poultry flocks frequently originated from persistent lineages circulating in regions of intensive poultry production. Our analysis of long-term surveillance data demonstrates that meaningful insights can be inferred from integrating ecosystem into phylogeographic reconstructions that may be consequential for pandemic preparedness and livestock protection.
Association of poultry vaccination with interspecies transmission and molecular evolution of H5 subtype avian influenza virus
Open the record for dataset details and reuse information.
Data for: Schaub et al., Salt supersaturation as an accelerator of influenza A virus inactivation in 1-μl droplets
<p><strong>Experimental data</strong></p> <p>This folder contains the experimental data to the figures shown in the main manuscript and Supporting Information.</p> <p>Figure 1: inactivation curves for 1- and 2-μl NaCl droplet experiments at 30% RH + NaCl control (infectivity titer and genomic copy enumeration). "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 1: relative radius of NaCl droplets during evaporation. "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 2: inactivation curves for 1-μl NaCl and LiCl droplet experiments at 30 and 65% RH + NaCl and LiCl controls (infectivity titer and genomic copy enumeration). "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 2: relative radius of NaCl and LiCl droplets during evaporation. "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 3: inactivation curves for 1-μl NaCl and NaCl/sucrose droplet experiments at 30 % RH + NaCl and NaCl/sucrose controls (infectivity titer and genomic copy enumeration). "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 3: relative radius of NaCl and NaCl/sucrose droplets during evaporation. "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure 5: virus enumeration (infectivity titer and genomic copies) for virion integrity assay.</p> <p>Figure S2: relative radius of NaCl droplets during evaporation at 65% RH. "Efflorescence" indicates the time at which efflorescence was first observed.</p> <p>Figure S5: inactivation curves for bulk experiments at various NaCl molalities (infectivity titer).</p> <p>Figure S6: inactivation curves for 1-μl NaCl droplet experiment at 74% RH (infectivity titer and genomic copy enumeration).</p> <p>Figure S8: inactivation curves for bulk experiments at pH 11 (infectivity titer).</p> <p> </p> <p><strong>Abbrevations used:</strong></p> <p>GC = Genomic Copies</p> <p>LoQ = Limit of Quantification</p> <p>m = molality (mol/kg H2O)</p> <p>PFU = Plaque Forming Unit</p> <p>ul = microliter</p>
Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection
<p>Primary data of manuscript </p>
Computational Evidence for Bisartan Arginine Blockers as Next-Generation Pan-Antiviral Therapeutics Targeting SARS-CoV-2, Influenza, and Respiratory Syncytial Viruses (RawData)
Open the record for dataset details and reuse information.
Active components of commonly prescribed medicines affect influenza A virus-host cell interaction: a pilot study
<p>Supplementary file</p>
ATG9A facilitates the biogenesis of influenza A virus liquid condensates near the ER by dissociating recycling vesicles from microtubules
<p>Raw Data</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.