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544 results for “Metabolic Diseases”
Sex-based differences in short and longer term metabolic heart disease_Supplementary Figures
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Parkinson's disease-related brain metabolic patterns and neurodegeneration in isolated REM sleep behavior disorder
<p><span><b>Objective</b>: To elucidate the role of Parkinson's disease (PD)-related brain metabolic patterns as a biomarker in isolated rapid-eye-movement sleep behavior disorder (iRBD) for future disease conversion.</span></p> <p><span><b>Method</b>: This is a prospective cohort study consisting of 30 iRBD patients, 25 de novo PD patients with a premorbid history of RBD, 21 long-standing PD patients on stable treatment and 24 healthy controls. iRBD group was longitudinally followed up. All participants underwent <sup>18</sup>F-Fluorodeoxyglucose (FDG) PET and were evaluated with olfaction, cognition, and the Movement disorders society-Unified PD Rating Scale (MDS-UPDRS) at baseline. From FDG-PET scans, we derived metabolic patterns from the long-standing PD group (PD-RP) and de novo PD group with RBD (dnPDRBD-RP). Subsequently, we calculated the PD-RP and dnPDRBD-RP scores in iRBD patients. We validated the metabolic patterns in each PD group and separate iRBD cohort (<i>n</i>=14).</span></p> <p><span><b>Result</b>: The two patterns significantly correlated with each other and were spatially overlapping yet distinct. The MDS-UPDRS motor scores significantly correlated with PD-RP (<i>p</i> = 0.013) but not with dnPDRBD-RP (<i>p</i> = 0.076). In contrast, dnPDRBD-RP correlated with olfaction in butanol threshold test (<i>p</i> = 0.018) in iRBD subjects, but PD-RP did not (<i>p</i> = 0.21). High dnPDRBD-RP in iRBD patients predicted future phenoconversion with all cut-off ranges from 1.5 to 3 standard deviations of the control value, whereas predictability of PD-RP was only significant in a partial range of cut-off.</span></p> <p><b>Conclusion:</b> The dnPDRBD-RP is an efficient neuroimaging biomarker that reflects prodromal features of PD and predicts phenoconversion in iRBD that can be applied individually.</p>
Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice
<p>Many Amyotrophic Lateral Sclerosis (ALS) patients experience hypermetabolism, or an increase in measured versus calculated metabolic rate. The cause of hypermetabolism and the effects on neuronal metabolism in ALS are currently unknown, but the efficacy of dietary interventions shows promise for metabolism as an ALS therapeutic target. The goal of this study is to measure changes in metabolic pathways as a function of disease progression in spinal cords of the SOD1G93A mouse model of ALS. We conducted a comprehensive assessment of protein expression for metabolic pathways, antioxidants, chaperones, and proteases in lumbar spinal cord from male SOD1G93A mice at pre-onset, onset, and end-stages of the disease using targeted proteomic analysis. These results reveal that protein content of metabolic proteins including proteins involved in glycolysis, β‐oxidation, and mitochondrial metabolism is altered in SOD1G93A mouse spinal cord well before disease onset. The changes in mitochondrial metabolism proteins are associated with decreased maximal respiration and glycolytic flux in SOD1G93A dermal fibroblasts and increased hydrogen peroxide and lipid hydroperoxide production in mitochondria from sciatic nerve and gastrocnemius muscle fibers at end stage of disease. Consistent with redox dysregulation, expression of the glutathione antioxidant system is decreased, and peroxiredoxins and catalase expression are increased. In addition, stress response proteases and chaperones, including those involved in the mitochondrial unfolded protein response, are induced before disease onset. In summary, we report that metabolic and stress response changes occur in SOD1G93A lumbar spinal cord before motor symptom onset, and are primarily caused by SOD1G93A expression and do not vary greatly as a function of disease course.</p>
Predicting gut microbial behavior in human diseases via community metabolic modeling and machine learning
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THE IMPACT OF STATIN THERAPY ON METABOLICALLY ASSOCIATED STEATOTIC LIVER DISEASE IN UZBEKISTAN: A SHORT-TERM STUDY
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Dataset from Gut Microbial Community Structure, Metabolic Signature, and Resistome in Dyslipidemia: Implications for Cardiovascular Disease Management
<p>Dataset from Gut Microbial Community Structure, Metabolic Signature, and Resistome in Dyslipidemia: Implications for Cardiovascular Disease Management</p>
Evaluation of Therapeutic Adherence Among Patients Followed in the Department of Hereditary Metabolic Diseases at Necker Hospital
ClinicalTrials.gov study NCT07356557. IPD Sharing: NO. Countries: 1. Publications: 0.
Metabolic Syndrome and Fatty Liver Disease Among Egyptian Patients with Chronic HBV
ClinicalTrials.gov study NCT06589167. IPD Sharing: NO. Countries: 0. Publications: 13.
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
ClinicalTrials.gov study NCT05648214. IPD Sharing: YES. Countries: 1. Publications: 0.
Screening for Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD) at Al-Rajhy Hospital Nutrition Clinic. Assiut, Egypt
ClinicalTrials.gov study NCT04861012. IPD Sharing: UNDECIDED. Countries: 0. Publications: 23.
Frequency of Metabolic Dysfunction Associated Fatty Liver Disease in Patients With Acute Coronary Syndromes
ClinicalTrials.gov study NCT06456970. IPD Sharing: UNDECIDED. Countries: 0. Publications: 12.
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT05107349. IPD Sharing: YES. Countries: 1. Publications: 0.
Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
ClinicalTrials.gov study NCT02031770. IPD Sharing: NO. Countries: 1. Publications: 0.
Pilot Study of the Human Metagenome in Metabolic Diseases
ClinicalTrials.gov study NCT06363253. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
MAL-ED Metabolic: A Follow-Up of Chronic Disease at Puberty
ClinicalTrials.gov study NCT05121935. IPD Sharing: NO. Countries: 0. Publications: 5.
Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones
ClinicalTrials.gov study NCT05778695. IPD Sharing: NO. Countries: 1. Publications: 0.
Weight Loss and Cardiovascular Disease (CVD) Prevention Via a Whole Grain Diet in Men and Women With Metabolic Syndrome
ClinicalTrials.gov study NCT00455065. IPD Sharing: Not stated. Countries: 0. Publications: 1.
FFT, Inflammation, Lipid Metabolism, Blood Pressure and Organ Damage in Patients With Obesity, Chronic Kidney Disease (CKD).
ClinicalTrials.gov study NCT01332526. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Short Term Outcome of Metabolic Associated Fatty Liver Disease (MAFLD) in Patients Undergoing Bariatric Surgery
ClinicalTrials.gov study NCT06180928. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Regulation of Lipid Metabolism in Autoimmune Disease: Multiple Sclerosis
ClinicalTrials.gov study NCT04053374. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.