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2,042 results for “Preterm”
Code for: Multi-modal screening for synergistic neuroprotection of mild extremely preterm brain injury: Cell counting code repository
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East Africa preterm birth initiative birth register data (March 2016 - October 2016)
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Data from: Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term
<p><strong>Background</strong>: Recent studies suggest that alterations in the vaginal microbiome allow for the assessment of the risk for spontaneous preterm birth (PTB), the leading cause of neonatal morbidity and mortality worldwide. However, the associations between the local immune response and the vaginal microbiome are still poorly understood. Herein, we characterize the vaginal host immune-microbiome interactions in women who ultimately underwent PTB and in those who delivered at term.</p> <p><strong>Methods</strong>: Vaginal fluid samples from 52 pregnant women (of whom 18 underwent PTB and 34 delivered at term) were collected from 10-32 weeks in a case-control study. Concentrations of 33 immune mediators were determined using sensitive and specific immunoassays. The previously published 16S rRNA gene sequence and bacterial phylotype data of these subjects were utilized in this study. Linear mixed effects models were utilized to test associations between vaginal immune mediator concentrations and bacterial phylotype relative abundances.</p> <p><strong>Results</strong>: 1) Specific immune mediators (β-defensins 2 and 3, IL-1β, CXCL10, CCL2, CCL3, SLPI, and VEGF) correlated with 18 different vaginal bacterial phylotypes in the overall study population; 2) vaginal concentrations of CXCL10, CCL2, CCL3, SLP1 and VEGF negatively correlated with non-Lactobacillus members of the vaginal microbiome; 3) vaginal concentrations of CXCL10 were negatively correlated with 15 bacterial phylotypes, most of which are typical members of Community State Type IV of the vaginal microbiome, such as Gardnerella vaginalis, Megasphaera sp. type 1, and Atopobium vaginae; 4) Gemella spp. were negatively correlated with vaginal concentrations of VEGF, CCL2, CCL3, SLPI, and CXCL10; 5) when comparing PTB cases to term controls, five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16), and especially CCL26, were negatively correlated with five typical members of Community State Type IV: Sneathia sanguinegens, Parvimonas micra, Veillonellaceae, BVAB2, and Gemella spp; and 6) Sneathia sanguinegens had stronger negative associations with all five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16) in PTB cases than in term controls.</p> <p><strong>Conclusions</strong>: The assessment of vaginal host immune-microbiome interactions revealed that specific soluble immune mediators, mainly CXCL10, negatively correlated with typical members of Community State Type IV of the vaginal microbiome. In addition, this assessment particularly showed that Sneathia sanguinegens had stronger negative associations with different immune mediators, including CXCL10 and CCL26, in women who ultimately had a PTB compared to those who delivered at term. These findings provide insight into the vaginal host immune-microbiome interactions in normal and complicated pregnancies.</p>
Data from: Duration of cord clamping and neonatal outcomes in very preterm infants
Background: Delayed cord clamping (DCC, ≥30s) increases blood volume in newborns and is associated with fewer blood transfusions and short-term neonatal complications. The optimal timing of cord clamping for very preterm infants should maximize placental transfusion without interfering with stabilization and resuscitation. Aim: We compared the effect of different durations of DCC, 30-45s vs. 60-75s, on delivery room (DR) and neonatal outcomes in preterm infants <32 weeks gestational age (GA). Methods: This is a single-center prospective observational study. Data were collected prospectively from eligible infants from two groups: 30-45s DCC group (January 2008 to February 2011, n = 187) and 60-75s DCC group (March 2011 to April 2014, n = 166). Results: The 60-75s DCC group compared to the 30-45s DCC group had higher hematocrits at <2 hours (49.2% vs. 47.4%, p = 0.02). In infants <28 weeks GA, the 12–36 hours hematocrit was higher in the 60-75s DCC group compared to the 30-45s DCC group (47.9% vs. 42.1%, p = 0.002). The 60-75s DCC group had reductions in DR intubation (11% vs. 22%, p = 0.004), hypothermia on admission (1% vs. 5%, p = 0.01), surfactant therapy (13% vs. 28%, p = 0.001), intubation in the first 24 hours (20% vs. 34%, p = 0.004), any intubation (27% vs. 40%, p = 0.007), and any red blood cell transfusion (20% vs. 33%, p = 0.008) during the hospitalization compared to the 30-45s DCC group. These reductions remained significant after adjusting for GA, gender and >48 hours of antenatal steroid exposure. There was no difference between the two groups in neonatal death, intraventricular hemorrhage, chronic lung disease, late onset sepsis, necrotizing enterocolitis and severe retinopathy of prematurity. Conclusion: In this study cohort increasing DCC duration from 30-45s to 60-75s is associated with decreased hypothermia on admission, neonatal respiratory interventions and red blood cell transfusions without increase in neonatal mortality and morbidities.
Healthcare Professionals Interpersonal variability and determinants of medical decision thresholds for active management of extremely preterm infants in a level 3 perinatal center in France
<p>Raw data and R script</p>
Vaginal microbial communities and combination efforts predict preterm birth in Chinese women
<p>Elucidating the physiological and pathological characteristics of preterm birth is critical to the development of effective prediction and intervention strategies. Here, we present a nested case control study on 51 spontaneous preterm birth (sPTB) and 70 women who delivered at term. Systems-level analysis revealed bacterial compositions and functional differences between two distinct pregnancy outcomes. As expected, the vaginal environment with preterm birth was dominated by a more complex bacteria interaction network, and these interactions frequently exhibited opposite effects on different pregnancy outcomes. Furthermore, key species and combinations were identified to construct preterm birth prediction model. The final model contained three features generated from six bacteria (<em>A. christensenii</em> and <em>L. crispatus</em>; <em>B. breve</em> and <em>S. anginosus</em>; <em>P. timonensis</em> and <em>L. fermentum</em>) (AUROC = 0.942 for independent test). The AUROC value was 0.965 when white blood cell (WBC) and neutrophil (NEU) data were included. Collectively, our study provided a comprehensive characterization of the vaginal microbiome and revealed the potential utilization of bacteria in predicting the risk of preterm birth.</p>
Processed data for Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth.
<p>Processed data for the manuscript Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth.</p>
VentFirst: A Multicenter RCT of Assisted Ventilation During Delayed Cord Clamping for Extremely Preterm Infants
ClinicalTrials.gov study NCT02742454. IPD Sharing: NO. Countries: 2. Publications: 2.
Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women After Threatened Preterm Labor(PECEP-RETARD)
ClinicalTrials.gov study NCT01242384. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Lateral Position MRI in Preterm Infants, an Observational Study
ClinicalTrials.gov study NCT05776238. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Antenatal Model to Prevent Preterm Delivery
ClinicalTrials.gov study NCT01232192. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Validity of Transcutaneous Bilirubin Monitoring in Preterm Infants
ClinicalTrials.gov study NCT03195998. IPD Sharing: NO. Countries: 1. Publications: 9.
The Effect of Position Given to Preterms After Feeding on Gastric Residual Volume, Abdominal Oxygenation and Fractional Oxygen Extraction
ClinicalTrials.gov study NCT05888090. IPD Sharing: NO. Countries: 1. Publications: 23.
Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants
ClinicalTrials.gov study NCT03631979. IPD Sharing: NO. Countries: 1. Publications: 26.
Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage
ClinicalTrials.gov study NCT04278937. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Maternal Counseling for Preterm Deliveries, Assessing an Effective Method of Counseling
ClinicalTrials.gov study NCT02707237. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial
ClinicalTrials.gov study NCT07009366. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants
ClinicalTrials.gov study NCT02126501. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Creating a Calmer NICU: Optimizing Growth and Brain Development in Preterm Infants
ClinicalTrials.gov study NCT04911452. IPD Sharing: NO. Countries: 1. Publications: 5.
Gastric Residuals in Preterm Infants
ClinicalTrials.gov study NCT01337622. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.