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168 results for “Toxicology”
Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [NTO]
GEO Series GSE101886. Pimephales promelas. 12 samples. Type: Expression profiling by array.
Retinal organoids provide a suitable tool for toxicological drug screening – a comprehensive study validating well-known drug effects on retinal organoids
GEO Series GSE172138. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Comparative Toxicological Evaluation of the Insensitive Munition (IM) 1-methyl-3-nitroguanidine versus its UV-Degradation Products in Fathead Minnow
GEO Series GSE136782. Pimephales promelas. 40 samples. Type: Expression profiling by array.
Environmental Induced Epigenetic Transgenerational Inheritance of Pathology: Systems Epigenetics in Disease Etiology and Generational Toxicology
GEO Series GSE198452. Rattus norvegicus. 89 samples. Type: Methylation profiling by high throughput sequencing.
Toxicology study on KhES-3 cells.
GEO Series GSE60154. Homo sapiens. 12 samples. Type: Expression profiling by array.
Toxicological Transcriptome of Human Airway Constructs After Exposure to Indoor Air Particulate Matter: In Search of Relevant Pathways of Moisture Damage -Associated Health Effects
GEO Series GSE175878. Homo sapiens. 260 samples. Type: Expression profiling by high throughput sequencing.
Multiomics profiling of zebrafish embryonic cell line PAC2 across growth phases to assess its relevance for toxicological studies
GEO Series GSE303229. Danio rerio. 7 samples. Type: Expression profiling by high throughput sequencing.
Figure 2 from: Voynova M, Shkondrov A, Kondeva-Burdina M, Krasteva I (2020) Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine. Pharmacia 67(4): 317-323. https://doi.org/10.3897/pharmacia.67.e56112
Figure 2 Structure of muscarine.
Figure 3 from: Voynova M, Shkondrov A, Kondeva-Burdina M, Krasteva I (2020) Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine. Pharmacia 67(4): 317-323. https://doi.org/10.3897/pharmacia.67.e56112
Figure 3 Chemical changes of ibotenic acid to muscazone and muscimol.
Figure 1 from: Voynova M, Shkondrov A, Kondeva-Burdina M, Krasteva I (2020) Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine. Pharmacia 67(4): 317-323. https://doi.org/10.3897/pharmacia.67.e56112
Figure 1 A. muscaria (L.) Lam. in Belasitsa Mountain, Bulgaria.
Data from: Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio)
To screen the tens of thousands of chemicals for which no toxicity data currently exists, it is necessary to move from in vivo rodent models to alternative models, such as zebrafish. Here, we used dechorionated Tropical 5D wildtype zebrafish embryos to screen a 91-compound library provided by the National Toxicology Program (NTP) for developmental toxicity. This library contained 86 unique chemicals that included negative controls, flame retardants, polycyclic aromatic hydrocarbons (PAHs), drugs, industrial chemicals and pesticides. Fish were exposed to five concentrations of each chemical or an equal amount of vehicle (0.5% DMSO) in embryo medium from 6 h post-fertilization (hpf) to 5 d post-fertilization (dpf). Fish were examined daily for mortality and teratogenic effects and photomotor behavior was assessed at 4 and 5 dpf. Of the five negative control compounds in the library, none caused mortality/teratogenesis, but two altered behavior. Chemicals provided in duplicate produced similar outcomes. Overall, 13 compounds caused mortality/teratology but not behavioral abnormalities, 24 only affected behavior, and 18 altered both endpoints, with behavior affected at concentrations that did not cause mortality/teratology (55/86 hits). Of the compounds that affected behavior, 52% caused behavioral abnormalities at either 4 or 5 dpf. Compounds within the same functional group caused different behavioral abnormalities, while similar behavioral patterns were caused by compounds from different groups. Our data suggest that behavior is a sensitive endpoint for developmental toxicity screening that integrates multiple modes of toxic action and is influenced by the age of the larval fish at the time of testing.
Figure 1 from: Lyapina MG, Tsanova-Savova SP, Nikolova MG, Vizeva ML, Momekov GT (2024) Gallates – toxicological data and a pilot study on the prevalence of contact sensitization. Pharmacia 71: 1-6. https://doi.org/10.3897/pharmacia.71.e120507
Figure 1 Patch testing technique.
Evaluating the utility of the Threshold of Toxicological Concern (TTC) and its exclusions in the biocompatibility assessment of extractable chemical substances from medical devices
<p>Data supporting manuscript Patlewicz G, Nelms M, Rua D. Evaluating the utility of the Threshold of Toxicological Concern (TTC) and its exclusions in the biocompatibility assessment of extractable chemical substances from medical devices. Computational Toxicology, 2022, in press <a href="https://doi.org/10.1016/j.comtox.2022.100246" rel="nofollow">https://doi.org/10.1016/j.comtox.2022.100246</a></p>
Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment
<p>Supplementary information for the manuscript and raw data files underpinning the analysis are available here as compressed tar files. </p> <p>Please cite: Patlewicz G., Judson R., Williams A. J., Butler T., Barone Jr. S ., Carstens K. E., Cowden J., Dawson J. L., Degitz S. , Fay K., Henry T. R., Lowit A., Padilla S., Paul Friedman K., Phillips M. B., Turk D., Wambaugh J., Wetmore B., Thomas R.S. Development of Chemical Categories for Per- and Polyfluoroalkyl Substances (PFAS) and the Proof-of-Concept Approach to the Identification of Potential Candidates for Tiered Toxicological Testing and Human Health Assessment. <em>Computational Toxicology</em> <strong>2024</strong> <a href="https://doi.org/10.1016/j.comtox.2024.100327" rel="nofollow">https://doi.org/10.1016/j.comtox.2024.100327</a></p>
Optimizing Toxicological Screening in Drug Endangered Children
ClinicalTrials.gov study NCT01037569. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dichloroacetate Kinetics, Metabolism and Toxicology
ClinicalTrials.gov study NCT00015015. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Virtual MOUD Treatment- Virtual POC Toxicology
ClinicalTrials.gov study NCT05448118. IPD Sharing: NO. Countries: 1. Publications: 0.
Genetic toxicology and toxicogenomic analysis of 3 cigarette smoke condensates in vitro reveals few differences between high and low tar brands
GEO Series GSE30079. Mus musculus. 66 samples. Type: Expression profiling by array.
Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic Acid on rat kidneys
GEO Series GSE21210. Rattus norvegicus. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: Teratological and behavioral screening of the National Toxicology Program 91-compound library in zebrafish (Danio rerio)
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.