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1,218 results for “Vesicles”
Extracellular Vesicles as Biomarkers for Chronic Renal Failure
ClinicalTrials.gov study NCT04700631. IPD Sharing: NO. Countries: 1. Publications: 1.
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
ClinicalTrials.gov study NCT04761562. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Saliva and Extracellular Vesicles for Parkinson's Disease
ClinicalTrials.gov study NCT05320250. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Single vesicle fusion experiments illustrating the inhibition of the calcium triggered release by the inhibitory peptide SP9
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Data from: Effect of pancreatic cancer-derived extracellular vesicles on bone marrow-derived macrophages
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Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer
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Liquid chromatography tandem mass spectrometry of AMPA receptor containing vesicles
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Data from: Profiling extracellular long RNA transcriptome in human plasma and extracellular vesicles for biomarker discovery
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Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend healthspan in mouse models of aging.
<p>Source data file</p>
Data from: Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor.
Extracellular vesicles (EVs) are membrane enclosed nanostructures released by cells into the extracellular environment. As major actors of physiological intercellular communication, they have been shown to be pathogenic mediators of several liver diseases. EVs also appear to be potential actors of drug-induced liver injury, but nothing is known concerning environmental pollutants. We aimed to study the impact of polycyclic aromatic hydrocarbons (PAHs), major contaminants, on hepatocyte-derived EV production, with a special focus on hepatocyte death. Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Treatment of primary rat and WIF-B9 hepatocytes by all three PAHs increased the release of EVs, mainly comprised of exosomes, in parallel with modifying exosome protein marker expression and inducing apoptosis. Moreover, PAH treatment of rodents for three months also led to increased EV levels in plasma. The EV release involved CYP metabolism and the activation of the transcription factor, the AhR, for BP and DBA and another transcription factor, the constitutive androstane receptor (CAR), for PYR. Furthermore, all PAHs increased cholesterol levels in EVs but only BP and DBA were able to reduce the cholesterol content of total cell membranes. All cholesterol changes very likely participated in the increase in EV release and cell death. Finally, we studied changes in cell membrane fluidity caused by BP and DBA due to cholesterol depletion. Our data showed increased cell membrane fluidity, which contributed to hepatocyte EV release and cell death.
Data from: A well-defined readily releasable pool with fixed capacity for storing vesicles at calyx of held
The readily releasable pool (RRP) of vesicles is a core concept in studies of presynaptic function. However, operating principles lack consensus definition and the utility for quantitative analysis has been questioned. Here we confirm that RRPs at calyces of Held from 14 to 21 day old mice have a fixed capacity for storing vesicles that is not modulated by Ca2+. Discrepancies with previous studies are explained by a dynamic flow-through pool, established during heavy use, containing vesicles that are released with low probability despite being immediately releasable. Quantitative analysis ruled out a posteriori explanations for the vesicles with low release probability, such as Ca2+-channel inactivation, and established unexpected boundary conditions for remaining alternatives. Vesicles in the flow-through pool could be incompletely primed, in which case the full sequence of priming steps downstream of recruitment to the RRP would have an average unitary rate of at least 9/s during heavy use. Alternatively, vesicles with low and high release probability could be recruited to distinct types of release sites; in this case the timing of recruitment would be similar at the two types, and the downstream transition from recruited to fully primed would be much faster. In either case, further analysis showed that activity accelerates the upstream step where vesicles are initially recruited to the RRP. Overall, our results show that the RRP can be well defined in the mathematical sense, and support the concept that the defining mechanism is a stable group of autonomous release sites.
Reciprocal Communication between FAPs and Muscle Cells via Distinct Extracellular Vesicle miRNAs in Muscle Regeneration
<p>1 Metadata: Introduction of experimental design and protocol</p> <p>2 Known-miRNA map-MCEVPs: Small RNA reads from MC-EVPs were mapped against miRBase to identify known miRNAs.</p> <p>3 Known-miRNA map-FAPEVPs: Small RNA reads from FAP-EVPs were mapped against miRBase to identify known miRNAs.</p> <p>4 Readcount-TMP-1: The expression of known miRNAs was normalized by TPM (Transcripts per million).</p> <p>5 FAP-EVPs vs MCEVPs. differential analysis: Differential expressed miRNAs were analyzed by DEGseq and filtered with qvalue<0.01 &&|log2(foldchange)|>1.</p>
Long-chain lipids facilitate insertion of large nanoparticles into membranes of small unilamellar vesicles
<div> <p>DLS data and Cryo Images of SUVs-QDs</p> <p> </p> </div>
Extracellular Vesicles Serum, Plasma, CSF Multiplex Dataset
<p>This example dataset for MPAPASS software (v1.02) contains deidentified tetraspanin stained EV multiplex data from plasma, serum, CSF data. </p>
Data from: Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts
Synaptophysins 1 and 2 and synaptogyrins 1 and 3 constitute a major family of synaptic vesicle membrane proteins. Unlike other widely expressed synaptic vesicle proteins such as vSNAREs and synaptotagmins, the primary function has not been resolved. Here, we report robust elevation in the probability of release of readily releasable vesicles with both high and low release probabilities at a variety of synapse types from knockout mice missing all four family members. Neither the number of readily releasable vesicles, nor the timing of recruitment to the readily releasable pool was affected. The results suggest that family members serve as negative regulators of neurotransmission, acting directly at the level of exocytosis to dampen connection strength selectively when presynaptic action potentials fire at low frequency. The widespread expression suggests that chemical synapses may play a frequency filtering role in biological computation that is more elemental than presently envisioned.
Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2
<p>Tabular data underlying all figures. </p>
Raw data for 'Poly(sitosterol)-Based Hydrophobic Blocks in Amphiphilic Block Copolymers for the Assembly of Hybrid Vesicles'
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Research data supporting "Effect of Formulation Method, Lipid Composition and PEGylation on Vesicle Lamellarity: A Small-Angle Neutron Scattering Study"
<p>Research data supporting the paper:</p> <p>Nele V. et al., Langmuir (2019), DOI: 10.1021/acs.langmuir.8b04256</p>
Micelle vesicle lipid bilayer
SciDraw upload
Deepening the Insight into Poly(butylene oxide)-block-poly(glycidol) Synthesis and Self-assemblies: Micelles, Worms and Vesicles
<p>Data underlying the figures in the publication “Deepening the insight into poly(butylene oxide)-block-poly(glycidol) synthesis and self-assemblies: micelles, worms and vesicles”, published in <em>RSC Adv., </em><strong>2020</strong>, 10, 22701. <a href="https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra04274a#!divAbstract">https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra04274a#!divAbstract</a></p> <p>Table of contents:</p> <p><strong>1. Figure 2</strong>; Zip file containing the numerical data for the Kinetic studies of <em>Figure 2</em>.</p> <p><strong>2. Figure 3</strong>; Zip file containing the numerical data for the SEC and DSC traces of <em>Figure 3</em>.</p> <p><strong>3. Figure 4</strong>; Zip file containing the TEM, Cryo-TEM and CLSM images of the nano- and macroscopic self-assemblies, showed in <em>Figure 4</em>.</p> <p><strong>4. Figure 6</strong>; Zip file containing the TEM images of the nanoscopic self-assemblies formed by film rehydration, showed in <em>Figure 6</em>.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.