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Dataset results
351 results for “cognitive decline”
Music Therapy for Older Adults With Cognitive Decline Living in Care Homes
ClinicalTrials.gov study NCT05856604. IPD Sharing: NO. Countries: 1. Publications: 17.
Spinal Anesthesia Vs. Neve Block in Risk of Cognitive Decline
ClinicalTrials.gov study NCT06963229. IPD Sharing: NO. Countries: 1. Publications: 8.
Group Reminiscence Therapy for Elderly People With Cognitive Decline in Institutional Context
ClinicalTrials.gov study NCT03370796. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients
ClinicalTrials.gov study NCT00182065. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Vascular Cognitive Decline and Dementia
ClinicalTrials.gov study NCT06257823. IPD Sharing: YES. Countries: 1. Publications: 1.
Transcranial Magnetic Stimulation to Slow Down Cognitive Decline in Alzheimer's Disease
ClinicalTrials.gov study NCT07036328. IPD Sharing: YES. Countries: 1. Publications: 1.
Supplementary materials for: Long term effects of cholinesterase inhibitors on cognitive decline and mortality
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Predictive biomarkers of individual trajectories in elderly persons with subtle cognitive decline: APOE genotype data
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ATN-classification and clinical progression in subjective cognitive decline: the SCIENCe project
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Long-term dietary flavonoid intake and subjective cognitive decline in US men and women
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Supplemental Materials: Duration of poverty and subsequent cognitive function and decline among older adults in China, 2005-2018
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Cardiovascular risk factors and accelerated cognitive decline in midlife
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Data from: Accelerated epigenetic age and cognitive decline among urban-dwelling adults
Objectives. Epigenetic modifications are closely linked with aging, but their relationship with cognition remains equivocal. Given known sex differences in epigenetic aging, we explored sex-specific associations of three DNA methylation-based (DNAm) measures of epigenetic age acceleration (EAA) with baseline and longitudinal change in cognitive performance among middle-aged urban adults. Methods. We used exploratory data from a sub-group of participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with complete DNA samples and whose baseline ages were >50.0y (2004-2009) to estimate three DNAm EAA measures: (A) universal epigenetic age acceleration (AgeAccel); (B) intrinsic epigenetic age acceleration (IEAA) ; and (C) extrinsic epigenetic age acceleration (EEAA). Cognitive performance was measured at baseline visit (2004-2009) and first follow-up (2009-2013) with 11 test scores covering global mental status and specific domains such as learning/memory, attention, visuo-spatial, psychomotor speed, language/verbal and executive function executive. A series of mixed-effects regression models were conducted adjusting for covariates and multiple testing (N=147-156, ~51% men, k=1.7-1.9 observations/participant, mean follow-up time~4.7y). Results. EEAA, a measure of both biological age and immunosenescence, was consistently associated with greater cognitive decline among men on tests of visual memory/visuo-constructive ability (Benton Visual Retention Test: γ11=0.0512±0.0176, p=0.004) and attention/processing speed (Trail making test, part A: γ11=0.219±0.080, p=0.007). AgeAccel and IEAA were not associated with cognitive change in this sample. Conclusions. EEAA capturing immune system cell aging was associated with faster decline among men in domains of attention and visual memory. Larger longitudinal studies are needed to replicate our findings.
Minor neuropsychological deficits in patients with subjective cognitive decline
<p><b>Objective: </b>To determine the nature and extent of minor neuropsychological deficits in patients with subjective cognitive decline (SCD) and their association with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD).</p> <p><b>Method: </b>We analyzed data from n=449 cognitively normal participants (n=209 healthy controls, n=240 SCD patients) from an interim data release of the <i>German Center for Neurodegenerative Diseases<b> </b>Longitudinal Cognitive Impairment and Dementia Study</i> (DELCODE). An extensive neuropsychological test battery was applied at baseline for which we established a latent, five cognitive domain factor structure comprising learning & memory, executive functions, language abilities, working memory and visuospatial functions. We compared groups regarding global and domain-specific performance and correlated performance with different CSF markers of AD pathology.</p> <p><b>Results: </b>We observed worse performance (Cohen's d≈0.25-0.5, adjusted for age-, sex differences with ANCOVA) in global performance, memory, executive functions and language abilities for the SCD group compared to healthy controls. In addition, worse performance in these domains was moderately (r≈0.3) associated with lower CSF-Aβ42/40 and CSF-Aβ42/ptau181 in the whole sample and specifically in the SCD subgroup.</p> <p><b>Conclusions:</b> Within the spectrum of clinically unimpaired (i.e., "pre- mild cognitive impairment") cognitive performance, SCD is associated with minor deficits in memory, executive function and language abilities. The association of these subtle cognitive deficits with AD CSF biomarkers speaks to their validity and potential use for the early detection of underlying preclinical AD.</p>
Data from: Male cognitive performance declines in the absence of sexual selection
Sexual selection is responsible for the evolution of male ornaments and armaments, but its role in the evolution of cognition—the ability to process, retain and use information—is largely unexplored. Because successful courtship is likely to involve processing information in complex, competitive sexual environments, we hypothesized that sexual selection contributes to the evolution and maintenance of cognitive abilities in males. To test this, we removed mate choice and mate competition from experimental populations of Drosophila melanogaster by enforcing monogamy for over 100 generations. Males evolved under monogamy became less proficient than polygamous control males at relatively complex cognitive tasks. When faced with one receptive and several unreceptive females, polygamous males quickly focused on receptive females, whereas monogamous males continued to direct substantial courtship effort towards unreceptive females. As a result, monogamous males were less successful in this complex setting, despite being as quick to mate as their polygamous counterparts with only one receptive female. This diminished ability to use past information was not limited to the courtship context: monogamous males (but not females) also showed reduced aversive olfactory learning ability. Our results provide direct experimental evidence that the intensity of sexual selection is an important factor in the evolution of male cognitive ability.
Dysfunctions-of-Multiscale-Dynamic-Brain-Functional-Networks-in-Subjective-Cognitive-Decline
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Supplemental data: The association of dilated perivascular spaces with cognitive decline and incident dementia
<p><span><b>Objective:</b></span></p> <p><span>To determine if severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over four and eight years respectively, we analyzed data from a prospective cohort study.</span></p> <p><span><b>Methods: </b></span></p> <p>414 community dwelling older adults aged 72-92 were assessed at baseline and biennially for up to eight years, with cognitive assessments, consensus dementia diagnoses and 3T MRI imaging. The numbers of PVS in two representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in i) either region; ii) both regions; and those with iii) severe BG PVS and iv) severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed number and lacune number were calculated.</p> <p><span><b>Results:</b></span></p> <p>Participants with severe PVS pathology in both regions or in the CSO alone had greater decline in global cognition over four years, even after adjustment for the presence of other small vessel disease neuroimaging markers. The presence of severe PVS pathology in both regions was an independent predictor of dementia across eight years (OR 2.91, 95%CI 1.43–5.95, p= 0.003). Further, the presence of severe PVS pathology in all groups examined was associated with greater dementia risk at either year four or six.</p> <p><span><b>Conclusions: </b></span></p> <p>Severe PVS pathology is a marker for increased risk of cognitive decline and dementia, independent of other small vessel disease markers. The differential cognitive associations for BG and CSO PVS may represent differences in their underlying pathology.</p>
EEG p-adic quantum potential accurately identifies depression, schizophrenia and cognitive decline
<p>No diagnostic or predictive instruments to help with early diagnosis and timely therapeutic intervention are available as yet for most neuro-psychiatric disorders. A quantum potential mean and variability score (qpmvs), to identify neuropsychiatric and neurocognitive disorders with high accuracy, based on routine EEG recordings, was developed. Information processing in the brain is assumed to involve integration of neuronal activity in various areas of the brain. Thus, the presumed quantum-like structure allows quantification of connectivity as a function of space and time (locality) as well as of instantaneous quantum-like effects in information space (non-locality). EEG signals reflect the holistic (nonseparable) function of the brain, including the highly ordered hierarchy of the brain, expressed by the quantum potential according to Bohmian mechanics, combined with dendrogram representation of data and p-adic numbers. Participants consisted of 230 participants including 28 with major depression, 42 with schizophrenia, 65 with cognitive impairment, and 95 controls. Routine EEG recordings were used for the calculation of qpmvs based on ultrametric analyses, closely coupled with p-adic numbers and quantum theory. Based on area under the curve, high accuracy was obtained in separating healthy controls from those diagnosed with schizophrenia (p<0.0001), depression (p<0.0001), Alzheimer's disease (AD; p<0.0001), and mild cognitive impairment (MCI; p<0.0001) as well as in differentiating participants with schizophrenia from those with depression (p<0.0001), AD (p<0.0001) or MCI (p<0.0001) and in differentiating people with depression from those with AD (p<0.0001) or MCI (p<0.0001). The novel EEG analytic algorithm (qpmvs) seems to be a useful and sufficiently accurate tool for diagnosis of neuropsychiatric and neurocognitive diseases and may be able to predict disease course and response to treatment.</p>
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
ClinicalTrials.gov study NCT07392723. IPD Sharing: YES. Countries: 1. Publications: 0.
Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline
ClinicalTrials.gov study NCT01703702. IPD Sharing: Not stated. Countries: 3. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.