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Fig. 4 in Modelling The Bioclimatic Niche Of A Cohort Of Selected Mite Species (Acari, Acariformes) Associated With The Infestation Of Stored Products

Fig. 4. Response of A. siro to PETcoldQ.

Fig. 3 in Modelling The Bioclimatic Niche Of A Cohort Of Selected Mite Species (Acari, Acariformes) Associated With The Infestation Of Stored Products

Fig. 3. Average monthly relative humidity.

Fig. 2 in Modelling The Bioclimatic Niche Of A Cohort Of Selected Mite Species (Acari, Acariformes) Associated With The Infestation Of Stored Products

Fig. 2. Average monthly precipitation.

Fig.1 in Modelling The Bioclimatic Niche Of A Cohort Of Selected Mite Species (Acari, Acariformes) Associated With The Infestation Of Stored Products

Fig.1. Average monthly temperature.

Fig. 9 in Modelling The Bioclimatic Niche Of A Cohort Of Selected Mite Species (Acari, Acariformes) Associated With The Infestation Of Stored Products

Fig. 9. Response of Gl. domesticus to aridityIndexThornthwaite.

opencc-zeroApr 2022View details →

Protective effect conferred by prior infection and vaccination on COVID-19 in a healthcare worker cohort in South India

The emergence of newer variants with the immune escape potential raises concerns about breakthroughs and re-infections resulting in future waves of infection. We examined the protective effect of prior COVID-19 disease and vaccination on infection rates among a cohort of healthcare workers (HCW) in South India during the second wave driven mainly by the delta variant. Symptomatic HCWs were routinely tested by RT-PCR as per institutional policy. Vaccination was offered to all HCWs in late January, and the details were documented. We set up a non-concurrent cohort to document infection rates and estimated protective efficacy of prior infection and vaccination between 16th Apr to 31st May 2021, using a Cox proportional hazards model with time-varying covariates adjusting for daily incidence. Between June 2020 and May 2021, 2735 (23.9%) of 11,405 HCWs were infected, with 1412, including 32 re-infections, reported during the second wave. 6863 HCWs received two doses of vaccine and 1905 one dose. The protective efficacy of prior infection against symptomatic infection was 86.0% (95% CI 76.7% - 91.6%). Vaccination combined with prior infection provided 91.1% (95% CI 84.1% - 94.9%) efficacy. In the absence of prior infection, vaccine efficacy against symptomatic infection during the second wave was 31.8% (95% CI 23.5% – 39.1%). Prior infection provided substantial protection against symptomatic re-infection and severe disease during a delta variant-driven second wave in a cohort of health care workers.

opencc-zeroMay 2022View details →

Kidney transplantation waiting times and risk of cardiovascular events and mortality: a retrospective observational cohort study in Taiwan

Objectives: Patients with end-stage renal disease (ESRD) are at a high risk of cardiovascular events (CVEs), and kidney transplantation (KT) has been reported to improve risk of CVEs and survival. As the association of KT timing on long-term survival and clinical outcomes remains unclear, we investigated the association of different KT waiting times on clinical outcomes. Design: Retrospective observational cohort study. Setting: We conducted an observational cohort study using data from the National Health Insurance Research Database in Taiwan. Adult patients who initiated kidney transplantation therapy from 1997 to 2013 were included. Participants: A total of 3562 adult patients who initiated uncomplicated KT therapy were included and categorized into four groups according to KT waiting times after ESRD: Group 1 (<1 year), Group 2 (1–3 years), Group 3 (3–6 years), and Group 4 (>6 years). Primary outcome measure: The main outcome was a composite of all-cause death, nonfatal myocardial infarction, or nonfatal stroke, based on the primary diagnosis in medical records during hospitalization. Results: Compared with Group 1, the adjusted risk of primary outcome events (all-cause death, nonfatal myocardial infarction, or nonfatal stroke) increased by 1.67 times in Group 2 (95% CI: 1.40–2.00; P <0.001), 2.17 times in Group 3 (95% CI: 1.73–2.71; P <0.001), and 3.10 times in Group 4 (95% CI: 2.21–4.35; P <0.001). The rates of primary outcome events were 6.7%, 13.4%, and 14.0% within five years, increasing to 19.5%, 26.3%, and 30.8% within 10 years in Groups 1, 2, and 3, respectively. Conclusions: Our results demonstrate that early KT is associated with superior long-term cardiovascular outcomes compared to late KT in selected ESRD patients receiving uncomplicated KT, suggesting that an early KT could be a better treatment option for ESRD patients who are eligible for transplantation.

opencc-by-4.0Jun 2022View details →

Dolutegravir in Real Life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral therapy in a prospective cohort study in Lesotho

Pseudonymized dataset for the accepted manuscript "Dolutegravir in Real Life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral therapy in a prospective cohort study in Lesotho"

opencc-zeroJun 2022View details →

Incidence of SARS-CoV-2 reinfection in a pediatric cohort in Kuwait

Objective: Subsequent protection from severe acute respiratory syndrome-related coronavirus 2 (SARS-COV-2) infection in pediatrics is not well reported in the literature. We aimed to describe the clinical characteristics and dynamics of SARS-CoV-2 PCR repositivity in children. Design: This is a population-level retrospective cohort study Setting: Patients were identified through multiple national-level electronic coronavirus disease 2019 (COVID-19) databases covering all Kuwait's primary, secondary and tertiary centers. Participants: The study included children 12 years and younger over an 11-month period between 2020 and 2021. SARS-CoV-2 reinfection was defined as having two or more positive SARS-CoV-2 PCR done on a respiratory sample, at least 45 days apart. Clinical data were obtained from the Pediatric COVID-19 Registry in Kuwait (PCR-Q8). Primary and secondary outcome measures: The primary measure is to estimate the SARS-CoV-2 PCR repositivity rate. The secondary objective was to establish average duration between first and subsequent SARS-CoV-2 infection. Descriptive statistics was used to present clinical data for each infection episode. Also, incidence-sensitivity analysis was performed to evaluate 60- and 90-day PCR repositivity intervals. Results: Thirty pediatric COVID-19 patients had SARS-CoV-2 reinfection at an incidence of 1.02 (95% CI 0.71-1.45) infection per 100,000 person-days and a median time to reinfection of 83 days (IQR 62-128.75). The incidence of reinfection decreased to 0.78 (95% CI 0.52-1.17) and 0.47 (95% CI 0.28-0.79) per person-days when the minimum interval between PCR repositivity was increased to 60 and 90 days, respectively. The mean age of reinfected subjects was 8.5 years (IQR 3.7-10.3) and the majority (70%) were females. Most children (55.2%) had asymptomatic reinfection. Fever was the most common presentation in symptomatic patients. One immunocompromised experienced two reinfection episodes. Conclusion: SARS-CoV-2 reinfection is uncommon in children. Previous confirmed COVID-19 in children seems to result in milder reinfection.

opencc-by-4.0Jul 2022View details →

Brain-Derived Neurotrophic Factor and extracellular vesicle-derived miRNAs in an Italian cohort of individuals with obesity: a key to explain the link between depression and atherothrombosis.

This record contains raw data related to the article “Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis”  Abstract:  Background: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. Research Process: Associations among circulating BDNF, depression and EVderived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score. Results: BDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-g. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group.

opencc-zeroSep 2022View details →

Associations of adverse maternal experiences and diabetes on postnatal maternal depression and child social-emotional outcomes in a South African community cohort

Previous literature has identified associations between diabetes during pregnancy and postnatal maternal depression. Both maternal conditions are associated with adverse consequences on childhood development. Despite an especially high prevalence of diabetes during pregnancy and maternal postnatal depression in low- and middle-income countries, related research predominates in high-income countries. In a South African cohort with or without diabetes, we investigated associations between adverse maternal experiences with postnatal maternal depression and child social-emotional outcomes. South African mother-child dyads were recruited from the Bishop Lavis community in Cape Town. Participants consisted of 82 mother-child dyads (53 women had GDM or type 2 diabetes). At 14–20 months postpartum, maternal self-report questionnaires were administered to assess household socioeconomic status, food insecurity, maternal depressive symptoms (Edinburgh Postnatal Depression Scale (EPDS)), maternal trauma (Life Events Checklist), and child social-emotional development (Brief Infant Toddler Social Emotional Assessment, Ages and Stages Questionnaires: Social-Emotional, Second Edition). Lower educational attainment, lower household income, food insecurity, living without a partner, and having experienced physical assault were each associated with postnatal maternal depressive symptoms and clinical maternal depression (EPDS ≥ 13). Maternal postnatal depression, lower maternal educational attainment, lower household income, household food insecurity, and living in a single-parent household were each associated with child social-emotional problems. Stratified analyses revealed maternal experiences (education, income, food insecurity, trauma) were associated with postnatal maternal depressive symptoms and child social-emotional problems only among dyads with in utero exposure to diabetes. Women with pre-existing diabetes or gestational diabetes in LMIC settings should be screened for health-related social needs to reduce the prevalence of depression and to promote child social-emotional development.

opencc-by-4.0Oct 2022View details →

Virtual cohort of fetal cases with suspected coarctation of the aorta from fetal three-dimensional magnetic resonance images

The present dataset is a supplementary dataset to the paper: Hermida, U., van Poppel, M.P.M., Lloyd, D.F.A. et al. Learning the Hidden Signature of Fetal Arch Anatomy: a Three-Dimensional Shape Analysis in Suspected Coarctation of the Aorta. J. of Cardiovasc. Trans. Res. (2022). https://doi.org/10.1007/s12265-022-10335-9 Dataset Description: We present a database of fetal great arch anatomical models derived from a statistical shape model (SSM) of fetuses with suspected coarctation of the aorta (CoA). The dataset consists of 1000 meshes including the fetal ascending aorta, arterial duct and descending aorta. For each synthetic case, the corresponding PCA coefficients for the 10 first PCA modes, as well as their CoA risk score, are shared. PCA scores are provided both as raw scores and Z-scores.  To build the SSM, a dataset of 112 motion-corrected 3D fetal cardiovascular magnetic resonance (CMR) images and their corresponding segmentations from cases with suspected CoA was used. Data included confirmed CoA cases as well as false positive (FP) cases. Centerlines were extracted and aligned to build the SSM of the fetal great arches.  Source of funding This work was supported by the Wellcome Trust IEH Award [102431] (iFIND project), by core funding from the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z] and by the Rosetrees Trust [A2725]. The research was funded by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London and supported by the NIHR Clinical Research Facility. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. D.F.A. Lloyd acknowledges support from the Rothschild Foundation (2020/2017). P. Lamata holds a Wellcome Trust Senior Research Fellowship (209450/Z/17/Z).

opencc-by-4.0Mar 2024View details →

Mass Cytometry (CyTOF) FCS files from Priest et al. 2024. Human PBMC from longitudinal analysis of COVID-19, Bacterial Sepsis, mRNA vaccination cohorts.

Mass Cytometry (CyTOF) FCS files from Priest et al. "Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection." Research Square 2024.  Files are already normalised, debarcoded, gated, batch corrected and compensated as described in Priest et al.  Data is from Human PBMCs of londitudanal cohorts of Severe COVID-19, Sepsis and mRNA vaccine recipients.  Samples were barcoded, mixed and then split magnetically before staining with seperate antibody panels for CD3+ (CD4, Treg, Tfh, CD8, gdT) or CD3- (B cells, DC, NK, Monocytes) to give approximatly 1280 FCS files from 218 individuals.  A follow up experiment with a B-cell specific panel and Tetramers is included.  Patient level metadata and antibody panel details are included.

opencc-by-4.0Jun 2024View details →

Surgical Outcomes in Chiari 1 and Chiari 1.5 Malformation (pediatric cohort)

Anonymized dataset of the cohort of patients for the paper: Surgical Outcomes in Chiari 1 and Chiari 1.5 Malformation Treated by Posterior Fossa Reconstruction: A Comprehensive Analysis of 110 Pediatric Cases and Literature Review.

opencc-by-4.0Jul 2024View details →

Supplemental Table. Historical cohort of 560 well-described papillary craniopharyngiomas reported in the medical literature (560c).

Table listing the historical cohort of 560 well-described/illustrated individual papillary craniopharyngiomas reported in the medical literature, including their corresponding references.

opencc-by-4.0Jul 2024View details →

Strain diversity of human-residential Lactiplantibacillus plantarum across children cohorts of two ethnic groups geographically isolated

This file includes seven genes, groEL-ileS-murC-murE-pheS-pyrG-recA, and has been used for multi-site sequence typing (MLST) studies.

opencc-by-4.0Apr 2018View details →

Salivary levels of cariogenic bacterial species during orthodontic treatment with thermoplastic aligners or fixed appliances: a prospective cohort study

Dataset for the analyses of the paper.

opencc-by-nc-nd-4.0Jul 2018View details →

[Supp. mat.] Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort

Supplementary tables and figure of paper Spatio-temporal analysis for detection of pre-symptomatic shape changes in neuro-degenerative diseases: initial application to the GENFI cohort, for testing different number of clusters of the spatio-temporal regression. The supplementary materials shows results for 2 4 6 8 12 14 and 16 clusters. The 10 clusters analysis is in the paper.

opencc-by-4.0Jun 2019View details →

Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study

Extended data pertaining to the manuscript: "Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study"