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700 results for “ex vivo”
Effects of cold or warm ischemia and ex-vivo lung perfusion on the release of damage associated molecular patterns and inflammatory cytokines in experimental lung transplantation
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Data from: Phase-dependent differential in vitro and ex vivo susceptibility of Aspergillus flavus and Fusarium keratoplasticum to azole antifungals
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Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation
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Comparative molecular analysis of cancer behavior cultured in vitro, in vivo, and ex vivo
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Data from: Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells
HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested in vivo, reactivating cells do not die sufficiently to reduce cell-associated HIV DNA levels. We recently showed that following reactivation from latency, HIV infected cells generate the HIV specific cytotoxic protein Casp8p41 which is produced by HIV protease cleaving procaspase 8. However, cell death is prevented, possibly due to low procaspase 8 expression. Here, we tested whether increasing procaspase 8 levels in CD4 T cells will produce more Casp8p41 following HIV reactivation, causing more reactivated cells to die. Screening 1277 FDA approved drugs identified 168 that increased procaspase 8 expression by at least 1.7-fold. Of these 30 were tested for anti-HIV effects in an acute HIVIIIb infection model, and 9 drugs at physiologic relevant levels significantly reduced cell-associated HIV DNA. Primary CD4 T cells from ART suppressed HIV patients were treated with one of these 9 drugs and reactivated with αCD3/αCD28. Four drugs significantly increased Casp8p41 levels following HIV reactivation, and decreased total cell associated HIV DNA levels (flurbiprofen: p = 0.014; doxycycline: p = 0.044; indomethacin: p = 0.025; bezafibrate: P = 0.018) without effecting the viability of uninfected cells. Thus procaspase 8 levels can be increased pharmacologically and, in the context of HIV reactivation, increase Casp8p41 causing death of reactivating cells and decreased HIV DNA levels. Future studies will be required to define the clinical utility of this or similar approaches.
Data from: All-trans retinoic acid disrupts development in ex vivo cultured fetal rat testes. II: modulation of mono-(2-ethylhexyl) phthalate toxicity
Humans are universally exposed to low levels of phthalate esters (phthalates), which are used to plasticize polyvinyl chloride. Phthalates exert adverse effects on the development of seminiferous cords in the fetal testis through unknown toxicity pathways. To investigate the hypothesis that phthalates alter seminiferous cord development by disrupting retinoic acid signaling in the fetal testis, gestational day 15 fetal rat testes were exposed for 1-3 days to 10-6 M all-trans retinoic acid (ATRA) alone or in combination with 10-6 to 10-4 M mono-(2-ethylhexyl) phthalate (MEHP) in ex vivo culture. As previously reported, exogenous ATRA reduced seminiferous cord number. This effect was attenuated in a concentration-dependent fashion by MEHP co-exposure. ATRA and MEHP-exposed testes were depleted of DDX4-positive germ cells but not Sertoli cells. MEHP alone enhanced the expression of the retinoic acid receptor target Rbp1 and the ovary development-associated genes Wnt4 and Nr0b1, and suppressed expression of the Leydig cell marker, Star, and the germ cell markers, Ddx4 and Pou5f1. In co-exposures, MEHP predominantly enhanced the gene expression effects of ATRA, but the Wnt4 and Nr0b1 concentration-responses were non-linear. Similarly, ATRA increased the number of cells expressing the granulosa cell marker FOXL2 in testis cultures, but this induction was attenuated by addition of MEHP. These results indicate that MEHP can both enhance and inhibit actions of ATRA during fetal testis development and provide evidence that retinoic acid signaling is a target for phthalate toxicity in the fetal testis.
FIGURE 1 in Ex vivo three-dimensional reconstruction of Acutiramus: a giant pterygotid sea scorpion
FIGURE 1. The traditional reconstruction of Pterygotus from Clarke and Ruedemann (1912: pls. 67, 68): A. dorsal reconstruction; B. ventral reconstruction.
FIGURE 2 in Ex vivo three-dimensional reconstruction of Acutiramus: a giant pterygotid sea scorpion
FIGURE 2. Acutiramus and Erettopterus specimens showing the general morphology and arrangement of appendages and ventral structures. A, B. Acutiramus cummingsi from the Silurian (Pridoli), Bertie Group, Williamsville Formation, Bennett Quarry (= Buffalo Cement Company), Buffalo, NY (N 42.942, W 78.825). A. USNM PAL 60053 (Clarke and Ruedemann, 1912: pl. 72, fig. 1). B. NYSM 10193 (Clarke and Ruedemann, 1912: pl. 78, fig. 3). C. Acutiramus macrophthalmus (Hall, 1859) from the Silurian (Pridoli), Bertie Group, Fiddlers Green dolomite. No locality data. NYSM E3584. D. Erettopterus bilobus (Salter, 1856) from the Silurian (latest Llandovery and Wenlock) Patrick or Kip Burn formation, Scotland. NHMUK PI In 59342. A–C. Photographed under water. B, C. Photographs by Lisa Amati.
Supplementary material 1 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Supplementary information
Figure 9 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure 9 Comparative ex-vivo permeation analysis shows a statistically significant difference between PHCl-NEG and PHCl gel.
Figure 7 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure 7 The rheological relationships of PHCl-loaded nanoemulgel (PHCl-NEG) between: A. Viscosity and shear rate; B. Shear rate and shear stress.
Figure A3 from: Abdullah T, Al-Kinani K (2024) Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy. Pharmacia 71: 1-12. https://doi.org/10.3897/pharmacia.71.e115330
Figure A3 Photographic pictures displaying PHCl-NEG: A. Consistency and physical appearance; B. Rheological behavior measurement.
Ex vivo T2* and DTI parameters of brown and white adipose tissues in cold-exposed mice
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Multimodal Analysis for Human ex vivo Studies Shows Extensive Molecular Changes from Delays in Blood Processing
<p>This is an assembled raw data in Seurat object. Expression profiling data can be accessed from <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156989">https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE156989</a>.</p>
Dataset related to article "Development of a 3D ex vivo model of brain-leukemia interaction to study the role of Activin A in the Central Nervous System microenvironment"
<p>Excel file related to the article</p>
NanoString dataset for study: Real-time ex vivo perfusion of human lymph nodes invaded by cancer (REPLICANT): a feasibility study
<p>Raw NanoString data for study DOI:10.1002/path.5367</p>
Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis
<p>Processed count tables of scRNA-seq data generated for this study.</p>
Dasatinib in Advanced Non-small Cell Lung Cancer (NSCL) With Ex Vivo and In Vivo Assessment of Tumor Target Modulation
ClinicalTrials.gov study NCT00858403. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transplantation of Uncontrolled DCD Kidneys REconditioned by a Novel Ex-VIVo Perfusion MEthod
ClinicalTrials.gov study NCT05703633. IPD Sharing: NO. Countries: 0. Publications: 2.
Safety and Efficacy of Donor T-lymphocytes Depleted ex Vivo of Host Alloreactive T-cells (ATIR) in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a
ClinicalTrials.gov study NCT01794299. IPD Sharing: NO. Countries: 4. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.