Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
539
datasets available to search
ShareScore release 0.7.1
Dataset results
539 results for “loss of function.”
Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy
GEO Series GSE194218. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Loss of Antp function in Drosophila flight muscle precursors : RNAi in larval wing disc-associated myoblasts
GEO Series GSE268578. Drosophila melanogaster. 4 samples. Type: Expression profiling by high throughput sequencing.
SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation.
GEO Series GSE279619. Homo sapiens. 124 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Biallelic loss-of-function mutations in MAD1 result in systemic inflammation, clonal selection of aneuploid cells and high tumor susceptibility
GEO Series GSE197267. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
NUDT2 loss-of-function variants are associated with a recessive neurodevelopmental disease with mental retardation, movement disorder and peripheral neuropathy
GEO Series GSE230789. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
CD58 loss in tumor cells confers functional impairment of CAR T cells
GEO Series GSE201970. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Loss of Hoxa5 function affects Hox gene expression in different biological contexts
GEO Series GSE269950. Mus musculus. 57 samples. Type: Expression profiling by high throughput sequencing.
Human Dicer hotspot mutation induces both loss and gain of miRNA function [sRNA-seq]
GEO Series GSE274853. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
GEO Series GSE64078. Homo sapiens. 49 samples. Type: Expression profiling by high throughput sequencing.
Setd1a and Setd1b loss-of-function in murine macrophages
GEO Series GSE137944. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function [RNA-seq]
GEO Series GSE93097. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Loss-of-function of PTPN2 promotes pathogenic loss of FoxP3+ in RORgt+ Tregs [ATAC-seq]
GEO Series GSE123486. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Blinding of virus-specific CXCR6+ CD8 T cells in the liver during chronic viral hepatitis causes loss of effector function
GEO Series GSE212925. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Loss of Function Mutations in ETS2 Repressor Factor (ERF) Reveal a Balance Between Positive and Negative ETS Factors Controlling Prostate Oncogenesis
GEO Series GSE83653. Homo sapiens; Mus musculus. 59 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Loss-of-function maternal-effect mutations of PADI6 are associated with familial and sporadic Beckwith-Wiedemann Syndrome with multi-locus imprinting disturbance
GEO Series GSE153211. Homo sapiens. 22 samples. Type: Methylation profiling by array.
Transcriptomic and epigenomic consequences of heterozygous loss-of-function mutations in AKAP11, a shared risk gene for bipolar disorder and schizophrenia [WGBS]
GEO Series GSE263850. Homo sapiens. 6 samples. Type: Methylation profiling by high throughput sequencing.
RNA-seq on dual-FACS sorted Drosophila Intestinal stem cell and Enteroblast, and effect of SPEN loss of function on gene expression
GEO Series GSE84367. Drosophila melanogaster. 11 samples. Type: Expression profiling by high throughput sequencing.
Interpheron-γ signaling is associated with BRCA-1 loss-of-function mutations in high grade serous ovarian cancer [ChIP-seq]
GEO Series GSE131140. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Whole genome expression analysis of a skin biopsy from an individual with multi-organ epithelial inflammation associated with an inherited loss-of-function mutation in EGFR
GEO Series GSE54162. Homo sapiens. 5 samples. Type: Expression profiling by array.
Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage
GEO Series GSE268181. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.