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143
datasets available to search
ShareScore release 0.9.0
Dataset results
143 results for “neurodegenerative diseases”
Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases
GEO Series GSE171992. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis
GEO Series GSE172108. Mus musculus. 12 samples. Type: Expression profiling by array.
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease
GEO Series GSE221404. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases
GEO Series GSE101689. Mus musculus. 246 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Neuromodulation and FMRI in Neurodegenerative Diseases Study
ClinicalTrials.gov study NCT06873750. IPD Sharing: NO. Countries: 0. Publications: 0.
Single Arm Clinical Trial of Small Molecule Natural Flavonoid Compounds for Intervention in Neurodegenerative Diseases
ClinicalTrials.gov study NCT05947409. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Eye Gaze Strategies During Facial Emotion Recognition in Neurodegenerative Diseases: Links With Neuropsychiatric Disorders (EYE-ToM Study)
ClinicalTrials.gov study NCT04748263. IPD Sharing: NO. Countries: 0. Publications: 0.
Study of Cerebral Glucose Metabolism in Neurodegenerative Diseases and Head Trauma
ClinicalTrials.gov study NCT06180213. IPD Sharing: NO. Countries: 0. Publications: 0.
Randomized Control Trial of Small-Molecule Natural Flavonoids Intervention for Neurodegenerative Diseases
ClinicalTrials.gov study NCT05947396. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Contribution of the Therapies of Resolution of Problem in the Care of the Natural Caregivers of Patients Affected by Neurodegenerative Disease Living at Home
ClinicalTrials.gov study NCT03438513. IPD Sharing: Not stated. Countries: 0. Publications: 0.
TREM2 supports neuronal protection and microglial reactivity independently of affecting misfolded protein deposition in chronic neurodegenerative prion disease
GEO Series GSE281022. Mus musculus. 14 samples. Type: Expression profiling by array.
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases III
GEO Series GSE101688. Mus musculus. 50 samples. Type: Expression profiling by array.
Genome-wide analysis of RARβ transcriptional targets in mouse striatum links retinoic acid signaling with Huntington’s disease and other neurodegenerative disorders
GEO Series GSE67761. Mus musculus. 11 samples. Type: Expression profiling by array.
The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases I
GEO Series GSE101686. Mus musculus. 63 samples. Type: Expression profiling by array.
The Prion Protein (PrP) is involved in translation via RNA granule-like mRNPs, a connection which is impaired during neurodegenerative diseases
GEO Series GSE57233. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Genome variation profiling by high throughput sequencing.
Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism
GEO Series GSE23151. Homo sapiens. 26 samples. Type: SNP genotyping by SNP array.
Prenatal low-dose MeHg exposure leads to proteomic and transcriptomic alterations consistent with neurodegenerative disease in the cerebellum of C57BL/6 mice
GEO Series GSE308270. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Clinical and biochemical markers of the neurodegenerative process in Alzheimer's disease
Open the record for dataset details and reuse information.
Dataset for the project "Identifying disease signatures of neurodegenerative dementias: a focus on autoimmunity and inflammation" Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2019-12369272)
<p><strong><span>Dataset for the project “Identifying disease signatures of neurodegenerative dementias: a focus on autoimmunity and inflammation” Italian Ministry of Health, Italy, Ricerca Finalizzata (Grant RF-2019-12369272)</span></strong></p> <p><strong><span>Specific Aim 1</span></strong></p> <p><span>To identify an immune-system genetic profile associated with disease onset, clinical phenotype and progression in AD and FTLD patients</span></p> <p><strong><span>Specific Aim 2</span></strong></p> <p><span>To identify an inflammatory/autoimmune biochemical signature associated with disease onset, clinical phenotype and progression in AD and FTLD patients</span></p> <p><strong><span>Specific Aim 3</span></strong></p> <p><span>To study the molecular mechanism involved in anti-GluA3 mediated synaptic, cellular and functional dysfunctions leading to neurodegeneration</span></p> <p><span>The present dataset contains the following folders:</span></p> <ul> <li><strong><span>Aim1:</span></strong><span> </span></li> <ul> <li><span>gVCF: a folder containing all gVCF files for each sample sequenced</span></li> <li><span>Correspondence: a dataset (excel file) containing sample name, group and corresponding g.vcf file name</span></li> <li><span>Gene selected for panel design: an excel file with the 50 genes included in the NGS panel</span></li> <li><span>RawData-RF2019_variants: an excel file containing results included in an article published in IJMS (Int J Mol Sci. 2024; 25(13):7457. doi: 10.3390/ijms25137457) already openly available in the Zenodo Data Repository at doi: 10.5281/zenodo.11659282.</span></li> </ul> </ul> <ul> <li><strong><span>Aim2</span></strong><span>: </span></li> <ul> <li><span>NTA_file: a folder containing Raw NTA file for each sample (from these files we extracted EV concentration and size)</span></li> <li><span>Anti-GluA3_analyses: a dataset (excel file) containing ID sample, diagnosis, group, Anti-GluA3 values from ELISA assay</span></li> <li><span>Biochemical_analyses_UO1: a dataset (excel file) containing sample, group, Raw NTA File name and MHC-II levels from ELISA assay</span></li> <li><span>Biochemical_analyses_UO2: a dataset (excel file) containing sample, group, cytokine/chemokine (Eotaxin, Eotaxin-3, IFN gamma, IL-1 beta, IL-6, IL-8, IL-10, IL-12p70, IP-10, MCP-1, MIP-1 beta, TARC, TNF alpha and IL-17A) levels from Luminex assay</span></li> </ul> </ul> <ul> <li><strong><span>Aim3:</span></strong><span> Results from aim 3 have been included in an article published in Brain, Behavior and Immunity (</span><span>Brain Behav Immun. 2024 May;118:380-397. doi: 10.1016/j.bbi.2024.03.018</span><span>).</span></li> <ul> <li><span>Behaviour: a folder containing datasets and raw data regarding different batches of behavioural analyses</span></li> <li><span>Biochemistry: a folder containing raw data regarding different western blot analyses</span></li> <li><span>Spine_Morphology</span><span>:</span><span> a folder containing datasets and raw data regarding spine morphology</span><span> analyses</span></li> </ul> </ul> <p><span>Users must clarify how they intend to use data here uploaded and whether the research protocol has been approved by an Ethics committee. Data on unpublished results will be available, under the same restrictions, after publication.</span></p>
Microglia-specific loss of PU.1 function rescues neurodegenerative phenotypes in a mouse model of Alzheimer’s disease
GEO Series GSE117868. Mus musculus. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.