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124 results for “phospholipids”
Effect of the deletion of the genes involved in phospholipid synthesis pathway on gene expression (DKO)
GEO Series GSE269277. Saccharomyces cerevisiae. 9 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency
<p>This record contains raw data related to the article "Plasma phospholipid dysregulation in patients with cystathionine-β synthase deficiency"</p> <p><strong>ABSTRACT</strong></p> <p> </p> <p><strong>Background & Aims:</strong> Patients with cystathionine β-synthase deficiency (CBSD) exhibit high circulating levels of homocysteine and enhanced lipid peroxidation. Because enhanced homocysteine plays key roles in methylation reactions that govern lipid metabolism, we have characterized the plasma lipidome in CBSD patients.</p> <p><strong>Methods and results:</strong> Using an ultra-high-performance liquid chromatography-electrospray ionization-quadrupole-time of flight- mass spectrometry method, plasma lipids were determined with an untargeted lipidomics approach in 11 CBSD patients and 11 matched healthy subjects (CTRL). Compared to CTRL, CBSD patients had a higher medium and long-chain polyunsaturated fatty acids (PUFA) content in phosphatidylethanolamine (PE) and lysophosphatidylethanolamine (LPE) species (p<0.02), and depletion of phosphatidylcholine (PC; p=0.02) and of lysophosphatidylcholine (LPC; p=0.003) species containing docosahexaenoic acid (DHA), suggesting impaired phosphatidylethanolamine-N-methyltransferase (PEMT) activity. PEMT needs methyl groups to convert PE into PC, S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). Whole blood SAM and SAH concentrations by liquid chromatography tandem mass spectrometry were 1.4-fold (p=0.015) and 5.3-fold (p=0.003) higher in CBSD patients than in CTRL. A positive correlation between SAM/SAH and PC/PE ratios (r=0.520; p=0.019) was found.</p> <p><strong>Conclusions:</strong> A novel biochemical abnormality in CBSD patients consisting in depletion of PC and LPC species containing DHA and accumulation of PUFA in PE and LPE species is revealed by this lipidomic approach. Changes in plasma SAM and SAH concentrations are associated with such phospholipid dysregulation. Given the key role of DHA in thrombosis prevention, depletion of PC species containing DHA in CBSD patients provides a new direction to understand the poor cardiovascular outcome of patients with homocystinuria and hyperhomocysteinemia.</p> <p>The data are those produced at Centro Cardiologico Monzino</p>
Anti-Phospholipid Antibodies and Coronavirus Disease 2019: Vaccination Does Not Trigger Early Autoantibody Production in Healthcare Workers
<p>A molecular mimicry between severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) and human proteins supports the possibility that autoimmunity takes place during coronavirus disease 2019 (COVID-19) contributing to tissue damage. For example, antiphospholipid antibodies (aPL) have been reported in COVID-19 as a result of such mimicry and thought to contribute to the immunothrombosis characteristic of the disease. Consistently, active immunization with the virus spike protein may elicit the production of cross-reactive autoantibodies, including aPL. We prospectively looked at the aPL production in healthcare workers vaccinated with RNA- (BNT162b2, n. 100) or adenovirus-based vaccines (ChAdOx1, n. 50). Anti-cardiolipin, anti-beta2 glycoprotein I, anti-phosphatidylserine/prothrombin immunoglobulin G (IgG), IgA, and IgM before and<br> after vaccination were investigated. Anti-platelet factor 4 immunoglobulins were also<br> investigated as autoantibodies associated with COVID-19 vaccination. Additional organ<br> (anti-thyroid) and non-organ (anti-nuclear) autoantibodies and IgG against human<br> proteome were tested as further post-vaccination autoimmunity markers. The<br> antibodies were tested one or three months after the first injection of ChAdOx1 and BNT162b2, respectively; a 12-month clinical follow-up was also performed. Vaccination occasionally induced low titers of aPL and other autoantibodies but did not affect the titer<br> of pre-existing autoantibodies. No significant reactivities against a microarray of approximately 20,000 human proteins were found in a subgroup of ChAdOx1-vaccinees. Consistently, we did not record any clinical manifestation theoretically associated with an underlying autoimmune disorder. The data obtained after the vaccination (two doses for the RNA-based and one dose for the adenovirus-based vaccines), and the clinical follow-up are not supporting the occurrence of an early autoimmune response in this cohort of healthcare workers.</p>
Lactobacillus casei - derived postbiotics inhibited digestion of triglycerides, glycerol phospholipids and sterol lipids via allosteric regulation of BSSL, PTL and PLA2 to prevent obesity: Perspectives on deep learning integrated multi-omics
<p>In view that the inhibition mechanism of inactivated probiotics on obesity remains limited, this study comprehensively investigated the potential mechanism of anti-obesity effect of heat inactivated <em>Lactobacillus casei</em> from the perspective of “lipid-metabolism-protein”.</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.