Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
152
datasets available to search
ShareScore release 0.9.0
Dataset results
152 results for “polygenes”
Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model II
GEO Series GSE271585. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profile of the hippocampus from a polygenic obese mouse model compared to a reference mouse line
GEO Series GSE280980. Mus musculus. 10 samples. Type: Expression profiling by array.
Data from: Assessing the complex architecture of polygenic traits in diverged yeast populations
Phenotypic variation arising from populations adapting to different niches has a complex underlying genetic architecture. A major challenge in modern biology is to identify the causative variants driving phenotypic variation. Recently the baker's yeast, Saccharomyces cerevisiae has emerged as a powerful model for dissecting complex traits. However, past studies using a laboratory strain were unable to reveal the complete architecture of polygenic traits. Here, we present a linkage study using 576 recombinant strains obtained from crosses of isolates representative of the major lineages. The meiotic recombinational landscape appears largely conserved between populations, however strain-specific hotspots were also detected. Quantitative measurements of growth in 23 distinct ecologically relevant environments show that our recombinant population recapitulates most of the standing phenotypic variation described in the species. Linkage analysis detected an average of 6.3 distinct QTLs for each condition tested in all crosses, explaining on average 39% of the phenotypic variation. The QTLs detected are not constrained to a small number of loci and the majority are specific to a single cross combination and to a specific environment. Moreover, crosses between strains of similar phenotypes generate greater variation in the offspring, suggesting the presence of many antagonistic alleles and epistatic interactions. We found that subtelomeric regions play a key role in defining individual quantitative variation, emphasising the importance of the adaptive nature of these regions in natural populations. This set of recombinant strains is a powerful tool for investigating the complex architecture of polygenic traits.
A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease
<p><a href="https://viz.stjude.cloud/communityData/PGS_snpLists.xlsx">Polygenic Risk Scores</a> is from the Pain study described below:</p> <p>Recurrent acute pain, or vaso-occlusive pain crisis (VOP), is the most common complication of sickle cell disease and correlates strongly with increased hospital visits and early mortality <a href="https://pubmed.ncbi.nlm.nih.gov/1710777/">PMID: 1710777</a>. While the genetics of VOP in sickle cell patients has been studied (PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29205277/">29205277</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/27883292/">27883292</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/25102390/">25102390</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/30079801/">30079801</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/22925497/">22925497</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29531649/">29531649</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29620434/">29620434</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/19468207/">19468207</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/20172753/">20172753</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/22576309/">22576309</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/30031848/">30031848</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/24136375/">24136375</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/27603703/">27603703</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/29559808/">29559808</a>), it is not fully understood.</p> <p>Using WGS, we interrogated the <em>a</em>-thalassemia deletion -<em>a</em>3.7 and 133 candidate risk single nucleotide polymorphisms (SNPs) across an additional 65 genes for association with VOP: 11 SNPs in 3 gene regions associated with fetal hemoglobin (HbF) and 122 additional SNPs in 62 genes previously reported to be associated with pain due to SCD and/or other etiologies. We then constructed unweighted polygenic risk scores (PGSs) by counting the total number of risk alleles per individual across the 11 HbF SNPs (PGSHbF) and the 5 SNPs in COMT (PGSCOMT), where COMT is the gene previously associated with SCD pain (PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29559808/">29559808</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/215537663/">15537663</a>). We also defined a final PGS comprised of these 16 SNPs plus another 5 internally-validated candidate SNPs (PGSHbF+COMT+5snps), which was more strongly associated with acute VOP than any individual variant. Additionally, patients with the highest 5% of scores had 3-fold more pain events than the bottom 5% but were 5 times more likely to be on hydroxyurea, indicating that patients with high scores might benefit from a second drug.</p>
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project
ClinicalTrials.gov study NCT06917794. IPD Sharing: NO. Countries: 1. Publications: 0.
DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores
ClinicalTrials.gov study NCT07358481. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Implementing a National Biobank of PD With WGS and Functional Assessment of Polygenic Inheritance by iPSC Technology
ClinicalTrials.gov study NCT05721911. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study
ClinicalTrials.gov study NCT06935344. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease
ClinicalTrials.gov study NCT04620980. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Clinical Implementation of a Polygenic Risk Score (PRS) for Breast Cancer
ClinicalTrials.gov study NCT03688204. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Disclosing Coronary Artery Disease Polygenic Risk Score on Cardiovascular Health
ClinicalTrials.gov study NCT07087431. IPD Sharing: YES. Countries: 1. Publications: 0.
Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health
ClinicalTrials.gov study NCT05819814. IPD Sharing: NO. Countries: 1. Publications: 0.
Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring
ClinicalTrials.gov study NCT04604353. IPD Sharing: NO. Countries: 1. Publications: 0.
Utility and Effectiveness of Polygenic Risk Scoring (PRS) for Coronary Artery Disease (CAD)
ClinicalTrials.gov study NCT06542432. IPD Sharing: Not stated. Countries: 1. Publications: 0.
UPBEAT: Using Polygenic Scores to Guide BB Therapy in HF With Mildly Reduced EF
ClinicalTrials.gov study NCT07054489. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
ClinicalTrials.gov study NCT06398639. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer
ClinicalTrials.gov study NCT06436248. IPD Sharing: NO. Countries: 1. Publications: 0.
Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions (striatum DBCBB).
GEO Series GSE89705. Homo sapiens. 33 samples. Type: Methylation profiling by array.
Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model I
GEO Series GSE255988. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Data from: Assessing the complex architecture of polygenic traits in diverged yeast populations
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.