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746 results for “seizures”
Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims
ClinicalTrials.gov study NCT01946802. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Efficacy of Intravenous Levetiracetam in Neonatal Seizures
ClinicalTrials.gov study NCT01720667. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures
ClinicalTrials.gov study NCT00152516. IPD Sharing: Not stated. Countries: 16. Publications: 1.
Safety, Tolerability, and Pharmacokinetic Study of Pregabalin in Pediatric Patients With Partial Onset Seizures
ClinicalTrials.gov study NCT00437281. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults
ClinicalTrials.gov study NCT01869374. IPD Sharing: NO. Countries: 1. Publications: 4.
Data from: Thalamus and focal to bilateral seizures: a multi-scale cognitive imaging study
Open the record for dataset details and reuse information.
EEG Recordings for: Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures
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A novel loss-of-function KCNB1 gene variant in a twin with global developmental delay and seizures
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Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
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Supplementary code and visualisations for "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy"
<p>MATLAB code and workspaces for reproducing the main results and figures of the paper "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy." Additional supplementary visualisations for all patients are also provided as PDFs. </p> <p>The paper preprint is available on bioRxiv: https://www.biorxiv.org/content/10.1101/661371v2</p>
Data from: Distinct epileptiform abnormalities are associated with clinical seizures in Alzheimer's disease
Objective: Examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer's disease (AD) and determine how these electrical biomarkers relate to the clinical expression of seizures in AD. Methods: In this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 early-stage AD participants with no history or risk factors for epilepsy (AD-NoEp), and 15 early-stage AD participants with late-onset epilepsy related to AD (AD-Ep). Two epileptologists, blinded to diagnosis, visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists, blinded to diagnosis, was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG. Results: Epileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC participants. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple electrical biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bi-temporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD. Conclusion: Epileptiform abnormalities are common in AD, but not all equivalent. Specific features of epileptiform discharges are associated with clinical seizures in AD. Given the difficulty recognizing clinical seizures in AD, these EEG features could provide guidance on which AD patients are at high risk for clinical seizures.
Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery
<p>Supplementary code and data for "Structural brain network abnormalities and the probability of seizure recurrence after epilepsy surgery<strong>" </strong></p> <p>https://doi.org/10.1212/WNL.0000000000011315</p>
Data from: Genetic assignment of large seizures of elephant ivory reveals Africa's major poaching hotspots
Poaching of elephants is now occurring at rates that threaten African populations with extinction. Identifying the number and location of Africa's major poaching hotspots may assist efforts to end poaching and facilitate recovery of elephant populations. We genetically assign origin to 28 large ivory seizures (≥0.5 tons) made between 1996-2014, also testing assignment accuracy. Results suggest that the major poaching hotspots in Africa may be currently concentrated in as few as two areas. Increasing law enforcement in these two hotspots could help curtail future elephant losses across Africa and disrupt this organized transnational crime.
03/04 - Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model
<p>Dataset #3 of 4</p>
01/04 - Spatial and Amplitude Dynamics of Neurostimulation: Insights from the Acute Intrahippocampal Kainate Seizure Mouse Model
<p>Dataset #1 of 4</p>
Data and code from "Full bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene micro-transistor depth neural probes"
<p>Data and python code for reproducing the main results of the paper "Full bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene micro-transistor depth neural probes."</p>
Synapsin II Directly Suppresses Epileptic Seizures in Vivo
<p>Videorecordings of seizure activity </p>
Supplementary visualisations for "Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states"
<p>Supplementary file containing patient-specific visualisations of seizure network state progressions and interictal spike rate decompositions for "Chronic iEEG recordings and interictal spike rate reveal multiscale temporal modulations in seizure states."</p> <p>See preprint at https://arxiv.org/abs/2201.11600</p>
Dataset related to article CXCL1-CXCR1/2 signaling is induced in human temporal lobe epilepsy and contributes to seizures in a murine model of acquired epilepsy
<p>Raw data are organized in an excel file where for each figure (included supll. figures) data are listed in a different sheet.</p>
Anti-seizure medication use during pregnancy and risk of ASD and ADHD in children
<p class="CxSpFirst"><b>Objective: </b>To determine whether children born to women who use anti-seizure medications (ASMs) during pregnancy have higher risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) independent of confounding factors.</p> <p class="CxSpMiddle"><b>Methods:</b> We used Swedish-register data (n=14,614 children born 1996-2011 and followed through 2013) to examine associations in children of women with epilepsy, using the largest sample to date and adjusting for a range of measured confounders. We examined maternal-reported first-trimester use of any ASM (22.7%); and the three most commonly reported individual drugs (valproic acid, 4.8%; lamotrigine, 6.8%; and carbamazepine, 9.7%). We identified ASD with ICD-10 diagnoses and ADHD with ICD-10 diagnoses or filled prescriptions of ADHD medication.</p> <p class="CxSpMiddle"><b>Results: </b>Examination of individual drugs revealed that after adjustment for confounding, use of valproic acid was associated with ASD (Hazard Ratio=2.30, 95%CI=1.53-3.47) and ADHD (HR=1.74, 95%CI=1.28-2.38). Whereas a small, non-statistically significant association with ASD (HR=1.25, 95%CI=0.88-1.79) and ADHD (HR=1.18, 95%CI=0.91-1.52) remained for reported use of carbamazepine, confounding explained all of the associations with lamotrigine (HR<sub>ASD</sub>=0.86, 95%CI=0.67-1.53; HR<sub>ADHD</sub>=1.01, 95%CI=0.67-1.53).</p> <p class="CxSpMiddle"><b>Conclusions: </b>We found no evidence of risk related to exposure to lamotrigine, whereas we observed elevated risk of ASD and ADHD related to maternal use of valproic acid. Associations with carbamazepine were weak and not statistically significant. Our findings add to a growing body of evidence that suggest that certain ASMs may be safer than others in pregnancy.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.