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194 results for “solvent”
The industrial solvent 1,4-Dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1
<p><strong>Background</strong>: The synthetic chemical 1,4-dioxane is used as industrial solvent, food and care product additive. 1,4-Dioxane has been noted to influence the nervous system in long-term animal experiments and in humans, but the molecular mechanisms underlying its effects on animals were not previously known.</p> <p><strong>Results:</strong> Here, we report that 1,4-dioxane potentiates the capsaicin-sensitive transient receptor potential (TRP) channel TRPV1, thereby causing hyperalgesia in mouse model. This effect was abolished by CRISPR/Cas9-mediated genetic deletion of TRPV1 in sensory neurons, but enhanced under inflammatory conditions. 1,4-Dioxane lowered the temperature threshold for TRPV1 thermal activation and potentiated the channel sensitivity to agonistic stimuli. 1,3-dioxane and tetrahydrofuran which are structurally related to 1,4-dioxane also potentiated TRPV1 activation. The residue M572 in the S4-S5 linker region of TRPV1 was found to be crucial for direct activation of the channel by 1,4-dioxane and its analogues. A single residue mutation M572V abrogated the 1,4-dioxane-evoked currents while largely preserving the capsaicin responses. Our results further demonstrate that this residue exerts a gating effect through hydrophobic interactions and support the existence of discrete domains for multimodal gating of TRPV1 channel.</p> <p><strong>Conclusions</strong>: Our results suggest TRPV1 is a co-receptor for 1,4-dioxane, and that this accounts for its ability to dysregulate body nociceptive sensation.</p>
Supplementary Information: On the Role of Dielectric Screening in Calculating Excited States of Solvated Azobenzene: A Benchmark Study Comparing Quantum Embedding and Polarizable Continuum Model for Representing the Solvent
<p>Link to Gitlab repo: https://gitlab.com/jezsmartinez/azobencene_ep/-/tree/main</p>
The physicochemical and thermal properties of deep eutectic solvent with different hydrogen bond donor (alpha hydroxy acid and polyol)
<p><span>Deep eutectic solvents (DESs) are a novel class of solvents that have gathered interest due to their unique properties particularly in its application of biomass fractionation. It is critical to study its properties from an engineering standpoint because of its importance in mass transfer, fluid mechanics, modelling, simulation and equipment design. The comparison of physicochemical and thermal properties of DESs has not been thoroughly investigated, particularly when a different functional group, such as alpha hydroxy acid (lactic acid, LA) or polyol (glycerol, Gly), is used as the hydrogen bond donor (HBD). Furthermore, understanding how molar ratios affect properties is crucial since they may be fine-tuned to meet the needs of specific applications. Thus, the purpose of this study is to determine the physicochemical properties (viscosity, density, refractive index and pH) and the thermal properties (freezing point and decomposition temperature) of DESs with different HBD functional groups (LA and Gly) at various molar ratios (1:2–1:10). The HBD's functional groups and molar ratio change significantly impacted the properties due to hydrogen bonding sites and strength, alkyl chain length and molecular weight and electrostatic and dispersion interactions. The correlation between DESs molar ratios and properties is not always linearly due to eutectic phenomena.</span></p>
Data for The Contribution of the Ion−Ion and Ion−Solvent Interactions in a 2 Molecular Thermodynamic Treatment of Electrolyte Solutions
<p>Data for the figures in the publication Kournopoulos et al. JPCB 2022</p>
NMR Data: Atomic Resolution Map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates
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Betaine–based natural deep eutectic solvents as sustainable electrolytes for the electrochemical energy storage devices
<p><span>The research project titled: <em>"</em></span><span><em><span>Betaine–based natural deep eutectic solvents as sustainable electrolytes for the electrochemical energy storage devices</span></em></span><em><span>"</span></em><span> focused on developing new, environmentally friendly liquid electrolytes for use in devices such as batteries, accumulators, and capacitors. The researchers concentrated on the development of so-called Natural Deep Eutectic Solvents (NADES) based on betaine and its derivatives, which have the potential to replace traditional, less eco-friendly electrolytes.</span></p> <p><span>Betaine is a natural chemical compound in plants like sugar beets, making it a fully renewable resource. Chemically, betaine is a derivative of the amino acid glycine, meaning it possesses a positive functional group at one end of the molecule and a negative charge at the opposite end. This gives betaine the characteristics of an ionic compound known as a zwitterion, which can be successfully used as <span>an electrolyte additive.</span></span></p> <p><span><span>During the </span>research, three different NADESs were synthesized, and betaine hydrochloride served as the hydrogen bond acceptor (HBA). At the same time, glycerol, ethylene glycol, and glycolic acid acted as hydrogen bond donors (HBD). The researchers then examined their physical properties, such as density, viscosity, pH, and conductivity, and assessed these substances' electrochemical stability.</span></p> <p><span>Among the studied NADES, the one based on betaine hydrochloride as the HBA and ethylene glycol as the HBD proved to be the most suitable electrolyte for supercapacitors due to its low viscosity and high ionic conductivity. Tests involving this substance demonstrated that devices using this electrolyte exhibited high specific capacitance and stability during prolonged use.</span></p> <p><span>The results confirm that NADES based on betaine can serve as a more sustainable alternative to conventional electrolytes, which is a step toward creating more environmentally friendly energy storage systems in the future.</span></p> <p><span>This research was founded on the whole by the National Science Centre, Poland (grant No. 2023/07/X/ST5/00629). For the purpose of Open Access, the author has applied a CC-BY public copyright to any Author Accepted Manuscript (AAM) version arising from this submission.</span></p>
Expanding the Potential of the Solvent-Assisted Method to CreateBio-Interfaces from Amphiphilic Block Copolymers
<p>Data underlying the figures in the publication “Expanding the Potential of the Solvent-Assisted Method to Create Bio-Interfaces from Amphiphilic Block Copolymers”, published in <em>Biomacromolecules, </em><strong>2021</strong><em>. <a href="https://doi.org/10.1021/acs.biomac.1c00424">https://doi.org/10.1021/acs.biomac.1c00424</a></em></p> <p>Table of contents:</p> <p><strong>1. Figure 1</strong>; Zip file containing the QCM-D data in <em>.qsd</em> format for <em>Figure 1</em>.</p> <p><strong>2. Figure 2_AFM</strong>; Zip file containing the AFM images for <em>Figure 2</em>.</p> <p><strong>3. Figure 3</strong>; Zip file containing the QCM-D data in <em>.qsd</em> format for <em>Figure 3</em>.</p> <p><strong>4. Figure 4</strong>; Zip file containing the QCM-D data in <em>.xls</em> format for <em>Figure 4</em>.</p> <p><strong>5. Figure 5</strong>; Zip file containing the QCM-D data in <em>.qsd</em> format for <em>Figure 5</em>.</p> <p><strong>6. Figure 6_Fluorimetry</strong>; Zip file containing the data in <em>.qsd</em> format for <em>Figure 6</em>.</p>
Solvent spotlight: Terpenes limonene and p-cymene
<p>Information about the use and properties of bio-based solvents limonene and p-cymene.</p>
Solvent spotlight: Propylene carbonate
<p>Uses and properties of propylene carbonate</p>
Solvent spotlight: N-butyl pyrrolidone
<p>The properties and uses of N-butyl pyrrolidone, a replacement solvent for N-methy pyrrolidone</p>
Solvent Spotlight: Supercritical carbon dioxide (CO2)
<p>An introduction to the properties and uses of carbon dioxide as a solvent.</p>
Solvent Dynamics of Aqueous Halides before and after Photoionization
<p>Raw data for the simulations discussed in our article "Solvent Dynamics of Aqueous Halides before and after Photoionization" published in J. Chem. Phys. B, https://doi.org/10.1021/acs.jpcb.2c07992</p>
solvent tutorial csc spring school 2023
<p>Input and output files tutorial solvent used in CSC spring school 26 April 2023</p>
Diformylxylose as a new polar aprotic solvent produced from renewable biomass
<p>The dataset contains raw data used to make the Figures and Tables in the main article and ESI. Specifically, it includes UV-spectra obtained in the mentioned dyes and used to calculate solvatochromic parameters, raw data produced by COSMO-RS software (charge density, settings, sigma profile and sigma potentials), raw GC-FID data used for quantifying Menshutkin reaction, raw data on acid stability of DFX, as well as raw data obtained during the toxicology test (Ames test). </p>
Fig. 5 in Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent, noncovalent interaction and solvent
Fig. 5. Energy diagram of the fHAT reaction between WEL and HOO• radical in water.
Fig. 1 in Theoretical study on the free radical scavenging potency and mechanism of natural coumestans: Roles of substituent, noncovalent interaction and solvent
Fig. 1. Basic structure of coumestans (coumestan) and its analogues.
Data from: Effect of reaction solvent on hydroxyapatite synthesis in sol-gel process
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Extractive desulfurization of liquid fuel using diamine-terminated polyethylene glycol as a very low vapor pressure and green molecular solvent
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Data from: Membrane-assisted extraction of monoterpenes: from in-silico solvent screening towards biotechnological process application
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The industrial solvent 1,4-Dioxane causes hyperalgesia by targeting capsaicin receptor TRPV1
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.