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954 results for “zinc”
Fig. 4 in Zinc uptake and HMA4 activity are required for micro- and macroelement balance in tobacco (Nicotiana tabacum)
Fig. 4. Relative elemental content of N. tabacum cv. #1 and cv. #2 HMA4 RNAi plants compared with their WT and of HMA4 double-knockout mutants compared with their null-segregants, for four different fertilization conditions: (a) normal fertilization, (b) fertilization containing lower concentrations of phosphate, (c) fertilization containing higher concentrations of Zn, and (d) fertilization with low concentrations of phosphate and high concentrations of Zn. The high Zn condition was achieved by addition of 0.1 g additional Zn per plant. The elements were measured in dry weight of leaves (mid-lower leaf position). Absolute data are listed in Supplementary Table S3. Data represent mean (0.95 CI) of n = 5 replicate plants, corrected according to Satterthwaite approximation. (Three outliers were removed for condition (d): Al and Cu for cv.#2; Ti for cv.#3.).
Fig. 3 in Zinc uptake and HMA4 activity are required for micro- and macroelement balance in tobacco (Nicotiana tabacum)
Fig. 3. Working model of metabolic changes in HMA4-impaired plants based on the gene expression changes observed in the roots and leaves of HMA4 RNAi and HMA4-mutant N. tabacum plants relative to their controls. The lack of HMA4 function causes Zn deficiency in leaves, leading to a local Zn-deficiency response. In roots, a Fe-deficiency response is observed, caused either by a high Zn:Fe ratio in the roots or by a systemic Zn-deficiency signal. The Fe-deficiency signal leads—via the transcription factor FIT1—to upregulation of the Fe- and Mn- transporter genes IRT1 and NRAMP1 and also induces the synthesis and export of iron-binding compounds (IBC), thus additionally assisting Fe uptake. At the same time, a P-deficiency signal involving the transcription factor HHO2 is generated in the leaves. In roots, the P-deficiency signal leads to increased expression of genes encoding acid phosphatases, enabling increased phosphate uptake from the rhizosphere. Consequently, Fe, Mn, Cu, and P accumulate in the leaves. P is stored in vacuoles (via PHT5; 1, PHT5; 3) and also exported to mitochondria and chloroplasts. Cu is detoxified by transport to the chloroplasts, which are a major site of Cu use because of Cu-containing plastocyanin production. However, high levels of Cu are toxic for the photosynthetic electron transport system, especially for photosystem II, which is reflected in the upregulation of PII light harvesting complex genes (LHCB). At the same time, Cu uptake to the cells is limited by downregulation of COPT1. Ion uptake might cause a lower osmotic potential, leading to water influx via various aquaporin genes. High turgor pressure or Fe excess ultimately affects the cell wall, as observed by the increased expression of genes involved in cell wall biosynthesis, expansion, and crosslinking. bHLH115: basic helix-loop-helix transcription factor; CA: carbonic anhydrase; CESA: cellulose synthase; COPT: copper transporter; DMRL: dimethyl-8-ribityllumazine synthase; EXPA: expansin; FIT: FER-like regulator of iron uptake (transcription factor); HHO2: hypersensitivity to low phosphate-elicited primary root shortening 1 homolog 2 (myb-like transcription factor); HMA: heavy metal ATPase; IBC: iron binding compound; IRT: iron-regulated transporter; LAC: laccase; LHCB: photosystem II light harvesting complex; NA: nicotianamine; NAS: nicotianamine synthase; NRAMP: natural resistance-associated macrophage protein (metal ion transporter); PDR: pleiotropic drug resistance (ATP-binding cassette transporter); PHT: phosphate transporter; PIP: plasma membrane intrinsic protein; PME: pectin methyl esterase; PMEI: pectin methyl esterase inhibitor; PRX: peroxidase; RBCS: ribulose bisphosphate carboxylase small chain; TIP: tonoplast intrinsic protein; TBL: TRICHOME BIREFRINGENCE-LIKE (xylan acetylation); ZIP: zinc transporter.
Effects of oral zinc supplementation in the prevention of community-acquired pneumonia in Colombian children: An economic evaluation
<p>Database : Effects of oral zinc supplementation in the prevention of community-acquired pneumonia in Colombian children: An economic evaluation</p>
Dose Adjustment Study of NPC-02 in Patients With Zinc Deficiency
ClinicalTrials.gov study NCT02321865. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Zinc Therapy in Acute Diarrhoea in Young Children
ClinicalTrials.gov study NCT00325247. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Family-based Health Education Program and Zinc Supplementation for Stunted Mother
ClinicalTrials.gov study NCT05100550. IPD Sharing: NO. Countries: 1. Publications: 5.
Impact of Targeted Zinc Fortification Programs on Plasma Zinc Concentration
ClinicalTrials.gov study NCT00944398. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia
ClinicalTrials.gov study NCT04326725. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Zinc, Mental Health, and School Performance in Guatemalan Schoolchildren
ClinicalTrials.gov study NCT00283660. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effects of Oral Supplementation of Arginine, Zinc and Vitamin C on Collagen Synthesis in Inguinal Hernia Patients
ClinicalTrials.gov study NCT03221686. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Iron and/or Zinc Supplementation in Mexican School Children Exposed to Lead
ClinicalTrials.gov study NCT02346188. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Relationship of Whole Blood Zinc Levels to Acne Severity
ClinicalTrials.gov study NCT04975412. IPD Sharing: NO. Countries: 1. Publications: 33.
Zinc Absorption From SQ-LNS With and Without Phytase
ClinicalTrials.gov study NCT02668133. IPD Sharing: NO. Countries: 1. Publications: 1.
Zinc Oxide Versus Petrolatum Following Skin Surgery
ClinicalTrials.gov study NCT03561376. IPD Sharing: NO. Countries: 1. Publications: 2.
Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis
ClinicalTrials.gov study NCT06567717. IPD Sharing: NO. Countries: 1. Publications: 4.
Zinc Absorption From Zinc Biofortified Rice
ClinicalTrials.gov study NCT01346722. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Zinc and the Synthesis of Zinc Binding Proteins (Protocol B)
ClinicalTrials.gov study NCT01221129. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Zinc Intake From Enriched Water and Other Dietary Sources in Kisumu, Kenya
ClinicalTrials.gov study NCT02162238. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Zinc Lozenges and Their Effect on Postoperative Sore Throat Syndrome
ClinicalTrials.gov study NCT02405832. IPD Sharing: NO. Countries: 1. Publications: 7.
Effectiveness and Safety of Whitfield's Solution, Zinc Oxide Nanoparticles Solution or Combination for the Treatment of Fungal Feet Infection
ClinicalTrials.gov study NCT05901961. IPD Sharing: NO. Countries: 1. Publications: 10.
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