Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,427
datasets available to search
ShareScore release 0.9.0
Dataset results
1,427 results for “Heart diseases”
The ACTonHEART Study: a Randomized Controlled Clinical Trial of a short intervention based on Acceptance and Commitment Therapy vs. usual care for cardiac rehabilitation patients with coronary heart disease.
<p>The ACTonHEART study evaluates the effectiveness of adding an ACT-based intervention to usual secondary prevention care of coronary heart disease, in order to promote healthy lifestyle changes and improve psychological wellbeing and quality of life among CR patients; psychological flexibility was a hypothesized mechanism of change.</p> <p>Ninety-two patients were enrolled and randomized, following an unbalanced randomization ratio of 2:1, to the ACT group (N= 59) and the control group (N= 33). The control group completed standard CR (Usual Care; UC) and the experimental subjects participated in the ACTonHEART group intervention in addition to standard CR. The ACTonHEART intervention consisted of three, two-hour, group sessions, focused on integrating acceptance and mindfulness skills into educational topics on heart-healthy behaviors. The primary study hypothesis is that the ACTonHEART group is superior to the UC group in the following primary outcome measures: LDL-cholesterol, resting systolic blood pressure, body mass index, and psychological wellbeing.</p> <p>Participants were assessed at baseline and at the end of the rehabilitation period. Linear mixed models analyses were used to detect the group x time interaction. Across all outcome variables, no time x treatment effect was found. The results of this study may inform the future implementations of ACT in the cardiac rehabilitation context.</p> <p>Corresponding author: Chiara Spatola (chiara.spatola@unime.it)</p>
Dataset related to the article : "The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus"
<p>This record contains raw data related to the article: The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus</p> <p>Abstract</p> <p>Human serum albumin (HSA) has an important antioxidant activity due to the presence of the reduced cysteine at position 34, which represents the most abundant free thiol in the plasma. In oxidative-based diseases, HSA undergoes S-thiolation (THIO-HSA) with changes in the antioxidant function of albumin that could contribute to the progression of the disease. The aim of this study was to verify, for the first time, the different burdens of THIO-HSA, glycated HSA (GLY-HSA), and advanced glycation end products (AGE) accumulation both in type 2 diabetes mellitus (T2DM) patients and in non-diabetic patients, with or without coronary heart disease (CHD). In this study, we assessed the presence of modified forms of HSA, THIO-HSA, and GLY-HSA by means of mass spectrometry in 33 patients with both T2DM and CHD, in 31 patients with T2DM and without CHD, in 30 patients without diabetes with a history of CHD, and 27 subjects without diabetes and CHD. All the patients' anthropometric and clinical data were recorded including age, sex, duration of diabetes, body mass index (BMI), blood pressure, and history of CHD defined with anamnestic data. Metabolic parameters, such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipids, pentosidine, AGE, receptor for advanced glycation end-products (RAGE) and its soluble form (sRAGE), were measured. AGE and pentosidine are significantly higher in T2DM patients with and without CHD with respect to non-diabetic patients with CHD and control subjects. RAGE levels are significantly higher in T2DM patients with respect to non-diabetic patients, and among T2DM patients, the group with CHD showed significantly higher RAGE levels than those without CHD (217 ± 171 pg/mL and 140 ± 61 pg/mL, respectively). Albumin isoforms discriminate between non-diabetic patients with CHD and T2DM patients with and without CHD and control subjects, with GLY-HSA levels higher in T2DM with and without CHD, and THIO-HSA higher in CHD patients without T2DM. Finally, we demonstrated that the oxidized forms of HSA can increase the expression of the inflammatory cytokine Tumor Necrosis Factor-alpha (TNFα) in monocytic cells. In patients with CHD, GLY-HSA and THIO-HSA have a different prevalent distribution, the first one prevailing in patients with T2DM and the second one in patients without T2DM. These findings suggest that albumin quality and homeostasis balance between glyco-oxidation and thiolation might have an impact on the antioxidant defense system in cardiovascular diseases.</p>
Lipoprotein Subfractions and Coronary Heart Disease During 25 Year Follow-up
ClinicalTrials.gov study NCT00005215. IPD Sharing: Not stated. Countries: 0. Publications: 0.
To Validate the Specific Patterns of Magnetocardiography, a Non-invasive Non-contact Examination for Patients With Ischemic Heart Disease or Cardiac Arrhythmia
ClinicalTrials.gov study NCT00965614. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Green Tea Consumption and Coronary Heart Disease
ClinicalTrials.gov study NCT00005548. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Natural History of Coronary Heart Disease
ClinicalTrials.gov study NCT00005265. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Change in Coronary Heart Disease Risk Factors in Young Adults
ClinicalTrials.gov study NCT00005406. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Physical Activity, Hypertension, Diabetes, and Coronary Heart Disease
ClinicalTrials.gov study NCT00005419. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Anger Expression, Self-focus and Coronary Heart Disease Risk Factors
ClinicalTrials.gov study NCT00005244. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Comparison of atrial appendage tissues of patients with Valvular Heart Disease and patients with Valvular Heart Disease-Atrial Fibrillation
GEO Series GSE113013. Homo sapiens. 10 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Delineating the angiogenic gene expression profile prior to pulmonary vascular remodeling in a lamb model of congenital heart disease
GEO Series GSE22590. Bos taurus; Ovis aries. 16 samples. Type: Expression profiling by array.
Genome-wide fetalization of enhancer architecture in heart disease [ChIP-Seq]
GEO Series GSE126571. Homo sapiens. 98 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Congenital heart disease in Csx/ Nkx2.5 mutant embryos
GEO Series GSE78. Mus musculus. 18 samples. Type: Expression profiling by array.
Transcriptomics reveals the molecular transcriptional regulatory network of Xinhuitong in the treatment of coronary heart disease with Qi deficiency and blood stasis syndrome
GEO Series GSE211248. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
NGS-based miRNome profile in cardiac muscle tissue of congenital heart disease patients
GEO Series GSE185565. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Single-cell dissection of ex vivo human heart tissue reveals pro-inflammatory microvascular changes in the right atrium in ischemic heart disease and heart failure
GEO Series GSE214731. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
NK2 model of congenital heart disease
GEO Series GSE528. Mus musculus. 26 samples. Type: Expression profiling by array.
Expression data from eight patients with coronary heart disease before and after Tongmai Yangxin Pills treatment for eight weeks.
GEO Series GSE142008. Homo sapiens. 16 samples. Type: Expression profiling by array.
Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease
GEO Series GSE169214. Mus musculus. 18 samples. Type: Expression profiling by array.
single-nucleus RNA-seq of healthy (sham) and heart diseased (TAC) SCGs
GEO Series GSE231765. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.