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1,389 results for “bladder cancer”
Dataset related to article "The Microbiome of Catheter Collected Urine in Males with Bladder Cancer According to Disease Stage"
<p>This record contains raw data related to article "The Microbiome of Catheter Collected Urine in Males with Bladder Cancer According to Disease Stage"</p> <p><strong>Purpose: </strong> The dogma that urine is sterile has been overturned and dysbiosis of the urinary microbiome has been linked to many urological disorders. We tested the hypothesis that the urinary microbial composition may be different between men with or without bladder cancer in catheter collected urines, bladder washouts and midstream voided urines, and may be dependent on tumor staging.</p> <p><strong>Materials and methods: </strong> Liquid samples were collected from male patients with bladder cancer, and sex and age matched nonneoplastic controls. Total DNA was extracted and processed for 16S rRNA gene sequencing. Bioinformatic analysis for microbial classification was performed to assess diversity and variations.</p> <p><strong>Results: </strong> The urinary microbiome associated with catheter collected urine samples of patients with bladder cancer was characterized by a significantly increased abundance of <em>Veillonella</em> (p=0.04) and <em>Corynebacterium</em> (p=0.03), and decreased <em>Ruminococcus</em> (p=0.03) compared to controls, with differences exacerbating with disease progression. Compared to catheterized urines, bladder cancer washouts showed the specific increase of some taxa, like <em>Burkholderiaceae</em> (p=0.014), whereas midstream urines were enriched in <em>Streptococcus</em> (p <0.0001), <em>Enterococcus</em> (p <0.0001), <em>Corynebacterium</em> (p=0.038) and <em>Fusobacterium</em> (p <0.0001).</p> <p><strong>Conclusions: </strong> The bladder is colonized by endogenous bacteria and microbial modifications characterize the microbiome of patients with bladder cancer. Different microbial compositions can be characterized by changing sampling strategy. These results pave the way for exploring new diagnostic and therapeutic options based on the manipulation of the bacterial community.</p>
Dataset related to article "Long-term outcomes of high-grade T1 bladder cancer treated with intravesical bacillus Calmette-Guérin: experience of a single center"
<p>This record contains raw data related to article "Long-term outcomes of high-grade T1 bladder cancer treated with intravesical bacillus Calmette-Guérin: experience of a single center"</p> <p>BACKGROUND:</p> <p>To assess the outcomes of patients with high-grade (HG) pT1 bladder cancer (BC) treated with intravesical BCG therapy.</p> <p>METHODS:</p> <p>The study population consisted of 185 patients with HG pT1 BC treated between 1998 and 2010. We aimed to determine recurrence-free (RFS) and progression-free survival (PFS), as well as the predictors of RFS and PFS.</p> <p>RESULTS:</p> <p>Overall, 143 (77.3%) patients were males. Median age was 72 years (IQR: 66-78). Tumor size was ≥3 cm in 100 (54.1%) individuals. Most patients had single tumors (125; 67.6%). Primary, progressive and recurrent patterns of presentation were observed in 146 (78.9%), 21 (11.4%), and 18 (9.7%) cases, respectively. After 2nd-look TURB, 127 (68.6%) patients had no residual disease, 44 (23.8%) had Ta/CIS, and 14 (7.6%) had T1 HG BC. Twenty-two (11.9%) patients experience early recurrence after BCG. Of these, 12 patients (54.5%) were diagnosed with Ta/CIS, while 10 (45.5%) were diagnosed with HG pT1 BC. The median follow-up was 93 months (IQR: 63-147). Ten-year RFS and PFS rates were 69.6 and 79.2%. In multivariable Cox regression models, female gender (HR=2.41; P=0.001), progressive (HR=2.03; P=0.030) and recurrent (HR=3.87; P<0.001) pattern of presentation emerged as independent predictors of RFS, while age ≥70 years (HR=2.13; P=0.027), presence of multiple tumors (HR=2.06; P=0.019), and early recurrence (HR=3.88; P<0.001) emerged as independent predictors of PFS.</p> <p>CONCLUSIONS:</p> <p>Intravesical BCG appears to be an effective treatment for HG pT1 BC. Caution should be used in patients aged ≥70 years, with multiple tumors or experiencing early recurrence.</p>
Dataset related to article: "Could We Safely Avoid a Second Resection in Selected Patients With T1 Non-Muscle-Invasive Bladder Cancer? Preliminary Results of Cost-Effectiveness Study From HUmanitas New Indications for ReTUR (HuNIRe) Multicenter Prospective Trial"
<p>The paper reports the preliminary results of a study which aims to avoid re-turbt in patients who have pT1</p>
CircNCOR1 suppresses lymphatic metastasis in bladder cancer
GEO Series GSE191036. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Expression data from human bladder cancer cell line with control or knock down of HP1γ (CBX3)
GEO Series GSE95400. Homo sapiens. 4 samples. Type: Expression profiling by array.
Discordant molecular subtype classification of muscle-invasive bladder cancer and matched lymph-node metastases occurs preferentially in the Basal/Squamous-like subtype.
GEO Series GSE101723. Homo sapiens. 28 samples. Type: Expression profiling by array.
The evolution and heterogeneity of lethal metastatic bladder cancer subtypes
GEO Series GSE302273. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of consensus molecular subtypes in muscle-invasive bladder cancer: A comparison of two sequencing methods and gene sets using FFPE specimens
GEO Series GSE225376. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Potential Roles of IGF2BP3 in Bladder Cancer [m6A-seq]
GEO Series GSE171023. Homo sapiens. 8 samples. Type: Methylation profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.