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1,445 results for “Irradiation”
Analysis of mRNA expression between irradiated and non-irradiated keloid-derived primary cells.
GEO Series GSE154234. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
ChIP-Seq of DNA lesions from irradiated and non-irradiated HaCaT cells
GEO Series GSE205250. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Profiling gene expression of the host response to an irradiated sporozoite immunization and Plasmodium vivax malaria challenge
GEO Series GSE85263. Homo sapiens. 55 samples. Type: Expression profiling by high throughput sequencing.
Influence of Freezing Temperature During Irradiation on the Biomechanical Properties of Irradiated Frozen Cortical Allograft
<p>Gamma irradiation minimizes the risk of infectious disease transmission and is the terminal sterilization method of choice for human cortical allografts. Its application is simple, and its results are reliable. Its more prominent indirect effect is strongly influenced by three main factors - the presence of oxygen, water and by temperature. There are, however, enduring concerns regarding its undesired adverse effects on the biomechanical properties of bone allografts. Even so, the available literature mentioning these effects had conflicting conclusions especially pertaining to the effect of temperature during the irradiation process. The purpose of this study was to examine the influence of freezing temperatures during gamma irradiation on the biomechanical properties of human cortical allografts. Five mid shaft femurs from cadaveric donors were cut into bone cubes measuring 4mm3. Each cube was assigned to one of 3 experimental groups. The first group was subjected to gamma irradiation at deep-freezing temperatures below -40°C (the Radiated in Dry ice / RD group), i.e. the recommended temperature for long-term storage of bone allografts. The second group was subjected to irradiation within a freezing temperature range of -40°C to 0°C (the Radiated in Gel ice / RG group) whilst the last group, acting as control (C group), did not receive irradiation treatment. Irradiation dose was set between 25 and 35 kGy. All samples were subsequently subjected to compressive load to failure to determine their biomechanical properties. Allografts irradiated at a higher freezing temperature range (RG, -40°C to 0°C) were observed to have a significantly lower yield point, ultimate tensile strength, resilience and toughness in comparison to those which were not irradiated (Control) and those irradiated at deep freezing temperatures (RD, below -40°C). The above four parameters of the Control and RD group samples were comparable. No difference in the Young’s modulus parameter was observed in all three groups. The results suggest that irradiation at deep freezing temperatures confers protection to the biomechanical properties of cortical femoral allografts, which may be the result of the complete immobilization of water molecules when deep frozen. With its inability to participate in the formation of free radicals via its radiolysis in the frozen state, the deleterious effects of radiation on collagen architecture are hence attenuated. The apparent loss of this protective effect when a higher freezing temperature range was employed during irradiation was substantiated.</p>
Dataset related to article "Impact of the Extremities Positioning on the Set-Up Reproducibility for the Total Marrow Irradiation Treatment"
<p>Abstract</p><p>Total marrow (lymph node) irradiation (TMI/TMLI) delivery requires more time than standard radiotherapy treatments. The patient's extremities, through the joints, can experience large movements. The reproducibility of TMI/TMLI patients' extremities was evaluated to find the best positioning and reduce unwanted movements. Eighty TMI/TMLI patients were selected (2013-2022). During treatment, a cone-beam computed tomography (CBCT) was performed for each isocenter to reposition the patient. CBCT-CT pairs were evaluated considering: (i) online vector shift (OVS) that matched the two series; (ii) residual vector shift (RVS) to reposition the patient's extremities; (iii) qualitative agreement (range 1-5). Patients were subdivided into (i) arms either leaning on the frame or above the body; (ii) with or without a personal cushion for foot positioning. The Mann-Whitney test was considered (p < 0.05 significant). Six-hundred-twenty-nine CBCTs were analyzed. The median OVS was 4.0 mm, with only 1.6% of cases ranked < 3, and 24% of RVS > 10 mm. Arms leaning on the frame had significantly smaller RVS than above the body (median: 8.0 mm/6.0 mm, p < 0.05). Using a personal cushion for the feet significantly improved the RVS than without cushions (median: 8.5 mm/1.8 mm, p < 0.01). The role and experience of the radiotherapy team are fundamental to optimizing the TMI/TMLI patient setup.</p><p> </p>
Dataset related to article "Evaluation of plan complexity and dosimetric plan quality of total marrow and lymphoid irradiation using volumetric modulated arc therapy"
<p>This record contains raw data related to article "Evaluation of plan complexity and dosimetric plan quality of total marrow and lymphoid irradiation using volumetric modulated arc therapy"</p><p> Abstract</p><p>Purpose: To assess the impact of the planner's experience and optimization algorithm on the plan quality and complexity of total marrow and lymphoid irradiation (TMLI) delivered by means of volumetric modulated arc therapy (VMAT) over 2010-2022 at our institute.</p><p>Methods: Eighty-two consecutive TMLI plans were considered. Three complexity indices were computed to characterize the plans in terms of leaf gap size, irregularity of beam apertures, and modulation complexity. Dosimetric points of the target volume (D2%) and organs at risk (OAR) (Dmean) were automatically extracted to combine them with plan complexity and obtain a global quality score (GQS). The analysis was stratified based on the different optimization algorithms used over the years, including a knowledge-based (KB) model. Patient-specific quality assurance (QA) using Portal Dosimetry was performed retrospectively, and the gamma agreement index (GAI) was investigated in conjunction with plan complexity.</p><p>Results: Plan complexity significantly reduced over the years (r = -0.50, p < 0.01). Significant differences in plan complexity and plan dosimetric quality among the different algorithms were observed. Moreover, the KB model allowed to achieve significantly better dosimetric results to the OARs. The plan quality remained similar or even improved during the years and when moving to a newer algorithm, with GQS increasing from 0.019 ± 0.002 to 0.025 ± 0.003 (p < 0.01). The significant correlation between GQS and time (r = 0.33, p = 0.01) indicated that the planner's experience was relevant to improve the plan quality of TMLI plans. Significant correlations between the GAI and the complexity metrics (r = -0.71, p < 0.01) were also found.</p><p>Conclusion: Both the planner's experience and algorithm version are crucial to achieve an optimal plan quality in TMLI plans. Thus, the impact of the optimization algorithm should be carefully evaluated when a new algorithm is introduced and in system upgrades. Knowledge-based strategies can be useful to increase standardization and improve plan quality of TMLI treatments</p>
WP3: Study cases of irradiated planetary atmospheres
<p>Report on the activities related to selection of <strong>representative study cases</strong> for simulations of irradiated planetary atmospheres and synthesis of ARIEL observations.</p>
Dataset related to article "Deep learning and atlas-based models to streamline the segmentation workflow of Total Marrow and Lymphoid Irradiation"
<p>This record contains raw data related to article “Deep learning and atlas-based models to streamline the segmentation workflow of Total Marrow and Lymphoid Irradiation"</p> <p>Abstract:</p> <p><strong>Purpose: </strong>To improve the workflow of Total Marrow and Lymphoid Irradiation (TMLI) by enhancing the delineation of organs-at-risk (OARs) and clinical target volume (CTV) using deep learning (DL) and atlas-based (AB) segmentation models.</p> <p><strong>Materials and Methods:</strong> Ninety-five TMLI plans optimized in our institute were analyzed. Two commercial DL software were tested for segmenting 18 OARs. An AB model for lymph node CTV (CTV_LN) delineation was built using 20 TMLI patients. The AB model was evaluated on 20 independent patients and a semi-automatic approach was tested by correcting the automatic contours. The generated OARs and CTV_LN contours were compared to manual contours in terms of topological agreement, dose statistics, and time workload. A clinical decision tree was developed to define a specific contouring strategy for each OAR.</p> <p><strong>Results: </strong>The two DL models achieved a median Dice Similarity Coefficient (DSC) of 0.84 [0.73;0.92] and 0.84 [0.77;0.93] across the OARs. The absolute median dose (Dmedian) difference between manual and the two DL models was 2% [1%;5%] and 1% [0.2%;1%]. The AB model achieved a median DSC of 0.70 [0.66;0.74] for CTV_LN delineation, increasing to 0.94 [0.94;0.95] after manual revision, with minimal Dmedian differences. Since September 2022, our institution has implemented DL and AB models for all TMLI patients, reducing from 5 to 2 hours the time required to complete the entire segmentation process.</p> <p><strong>Conclusion: </strong>DL models can streamline the TMLI contouring process of OARs. Manual revision is still necessary for lymph node delineation using AB models.</p> <p> </p> <p><strong>Statements & Declarations</strong></p> <p><strong>Funding:</strong> This work was funded by the Italian Ministry of Health, grant AuToMI (GR-2019-12370739).</p> <p><strong>Competing Interests:</strong> The authors have no conflict of interests to disclose.</p> <p><strong>Author Contributions:</strong> All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by D.D., N.L., L.C., R.C.B., D.L., and P.M. The first draft of the manuscript was written by D.D. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.</p> <p><strong>Ethics approval:</strong> The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Ethics Committee of IRCCS Humanitas Research Hospital (ID 2928, 26 January 2021). ClinicalTrials.gov identifier: NCT04976205.</p> <p><strong>Consent to participate: </strong>Informed consent was obtained from all individual participants included in the study.</p>
Coordinate regulation of galectins in GAL3 deficient mouse keratinocytes exposed to UVB irradiation
GEO Series GSE27599. Homo sapiens; Mus musculus. 24 samples. Type: Expression profiling by array.
Systemic signalling of irradiance and CO2 concentration in Arabidopsis (Controls)
GEO Series GSE5639. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Effect of low-level Er:YAG laser irradiation on proliferation and gene expression changes of primary gingival fibroblasts isolated from mouse maxilla.
GEO Series GSE227558. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Immediate response of hematopoietic stem cells to low doses of γ-irradiation
GEO Series GSE66374. Mus musculus. 3 samples. Type: Expression profiling by array.
Expression data from LT-HSCs from bone marrow non-irradiated, 8Gy CDR and 8Gy FLASH total body irradiated mice
GEO Series GSE54526. Mus musculus. 3 samples. Type: Expression profiling by array.
cDNA microarray analysis of human keratinocytes irradiated by ELF-EMF
GEO Series GSE3421. Homo sapiens. 11 samples. Type: Expression profiling by array.
Time course response of Synechocystis PCC 6803 to UV irradiation
GEO Series GSE4606. Synechocystis sp. PCC 6803. 6 samples. Type: Expression profiling by array.
transcriptomic assay on embryos after barley seeds gamma_irradiation-Molecular mechanisms of growth stimulation after low-dose irradiation of barley seeds
GEO Series GSE117356. Hordeum vulgare. 24 samples. Type: Expression profiling by array.
Bone Marrow Endothelial Cell Progenitor Cell and HUVEC T Cell Irradiation Studies
GEO Series GSE39020. Homo sapiens. 54 samples. Type: Expression profiling by array.
Transcriptome response to oxygen tension and light irradiation in Roseobacter denitrificans OCh114
GEO Series GSE152336. Roseobacter denitrificans OCh 114. 16 samples. Type: Expression profiling by array.
TIMED SEE Level 3A Solar Irradiance Data
SEE Level 3A data files contain each measurements averaged solar irradiance spectrum in 1 nm intervals extracted from the EGS Level 2A and XPS Level 2A data products. Shortward of 27 nm, a solar model is scaled to match the XPS broadband data. SEE Level 3A data files also contain 38 emission lines extracted from EGS Level 2A spectra, and the XPS Level 2A diode irradiances. For normal operations, SEE observes the Sun for about 3 minutes every orbit (97 minutes), which usually gives 14-15 measurements per day. The SEE Level 3A data are time averaged over each measurement, after applying corrections for atmospheric absorption, degradation, flare removal, and to 1-AU.
TSIS TIM Level 3 Total Solar Irradiance 24-Hour Means V04 (TSIS_TSI_L3_24HR) at GES DISC
Version 04 is the current release of this data product, and supercedes all previous versions.The TSIS TIM Level 3 Total Solar Irradiance (TSI) 24-Hour Means data product (TSIS_TSI_L3_24HR) uses measurements from the Total Irradiance Monitor (TIM) instrument over the entire spectrum, and averages them over a 24-hour period. TSIS-1 was launched on December 15, 2017 and mounted on the International Space Station (ISS) on December 30, 2017. TIM instrument has long-term repeatability with estimated uncertainties less than 0.014 W/m^2/yr (10 ppm/yr). Accuracy is currently reported as 0.48 W/m^2 (350 ppm), but expected to decrease as calibrations are refined and incorporated. Irradiances are reported at a mean solar distance of 1 AU and zero relative line-of-sight velocity with respect to the Sun.All of the data from this product are arranged into a single file in a tabular ASCII text format which can be easily read into a spreadsheet application. New data are appended to the file on a daily basis. The columns contain the date, Julian day, minimum wavelength, maximum wavelength, instrument mode, data version number, irradiance value, irradiance uncertainty, and data quality. The rows are arranged with data at each wavelength over the full TIM wavelength range, repeating for each day for the length of the mission.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.