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1,497
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Dataset results
1,497 results for “Ischemic stroke”
The role of a mammalian network in regulating ischemic stroke outcome I
GEO Series GSE213067. Mus musculus. 20 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The gene expression of microglia in the brain after ischemic stroke
GEO Series GSE269173. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke [dataset 5]
GEO Series GSE104047. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke [dataset 1]
GEO Series GSE104034. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Circulating angiogenic profiles in ischemic stroke and intracranial atherosclerosis (ICAD)
GEO Series GSE313670. Homo sapiens. 115 samples. Type: Non-coding RNA profiling by high throughput sequencing.
The role of a mammalian network in regulating ischemic stroke outcome II
GEO Series GSE213177. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation variability in a pilot study group with ischemic stroke
GEO Series GSE57962. Homo sapiens. 8 samples. Type: Methylation profiling by high throughput sequencing.
Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke
GEO Series GSE233213. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Intravenous NeuroD1 Gene Therapy Rescues Neurovascular Impairment After Ischemic Stroke
GEO Series GSE233329. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dynamic microglial gene expression profiles after ischemic stroke
GEO Series GSE172456. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke [dataset 4]
GEO Series GSE104043. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
NMR based serum metabolomics analysis revealed similar serum metabolic alterations in Ischemic and Hemorrhagic Stroke patients
<p><strong>Background and Objective: </strong>Brain stroke (caused by interrupted blood supply to the brain) is one of the most common causes of disability and is the second highest cause of death in the world. Early diagnosis and treatment raises the chance of surviving a stroke, and can result in little or no disability. Treatment is based on the type of stroke and its primary cause; for ischaemic stroke (IS), medication or surgery or both can be recommended, whereas, for haemorrhagic stroke (HS, also known as intracerebral hemorrhage), surgery is recommended. However, there are scarcity of clinical markers which can differentiate IS from HS and further can provide information about severity of cerebral ischemia, endothelial injury, blood–brain barrier disruption, atherosclerosis, thrombus formation, inflammation, and oxidative stress. Metabolomics is a promising approach for identification of metabolic biomarkers and alterations associated with the diseased biology The present study is an effort to identify the diagnostic panel of serum metabolic profiles to differentiate between IS and HS patients and further could help predicting the severity of the cerebral ischemia. <strong>Methods:</strong> Blood serum samples were collected from suspected brain stroke patients at hospital admission within 6 hours after onset. The serum samples of patients clinically confirmed for IS and HS were only analysed using 800 MHz NMR spectroscopy. For comparative evaluation, the serum samples from 60 age and sex matched normal control (NC) subjects were also obtained for NMR analysis. The partial least square-discriminant analysis (PLS-DA) was performed to confirm the serum metabolic disparity between the study groups and metabolic features of discriminatory relevance were identified making composite use of mean decrease accuracy (MDA) score values estimated for metabolic features employing machine learning random forest (RF) classification analysis. The diagnostic potential of discriminatory metabolites were finally evaluated using receiver operating characteristic (ROC) curve analysis. <strong>Results</strong>: The serum metabolic profiles of total 107 brain stroke patients (48 IS and 60 HS) were measured and compared with those of 60 age and sex matched normal control (NC) subjects. Compared to NC, the serum levels of various amino acids (histidine, glutamine, threonine, alanine, glycine, dimethylglycine, pyruvate, etc.) were found to be decreased in both HS and IS patients, whereas those of creatine, mannitol, mannose, malonate and organic acids (such as acetate, 3-hydroxybutyrate and 3-hydroxy-isobutyrate) were found to be increased in the sera of brain stroke patients. However, the area under ROC (AUROC) curve values for majority of metabolic features found to be less than 0.8 for the discrimination between IS and HS suggesting that circulatory metabolic features lack sufficient sensitivity and specificity. <strong>Conclusions:</strong> The study provided primary evidence that various circulatory metabolites (including histidine, glutamine, and alanine) exhibited strong diagnostic potential for distinguishing brain stroke condition from NC subject, however, poor diagnostic accuracy in distinguishing IS from HS. Nevertheless, these metabolic changes can be used to assess the severity of brain stroke condition and monitoring patient response to treatment in emergency settings.</p>
the Arraystar Human m6A-mRNA&lncRNA Epitranscriptomic microarray analysis in the neutrophils of ischemic stroke patients and healthy controls
GEO Series GSE236381. Homo sapiens. 6 samples. Type: Other.
Glycogen stress granules cause astrocytic mitochondrial dysfunction to aggravate ischemic damage and delay recovery after stroke
GEO Series GSE295882. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Gain-of-function PPM1D mutations attenuate ischemic stroke
GEO Series GSE295060. Mus musculus. 2 samples. Type: Other.
Rapid short- and long-range synaptic remodeling in hyperacute ischemic stroke
GEO Series GSE283465. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke [dataset 3]
GEO Series GSE104037. Mus musculus. 27 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing
GEO Series GSE178764. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke [dataset 6]
GEO Series GSE104048. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke
GEO Series GSE214644. Homo sapiens. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.