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25,372
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Dataset results
25,372 results for “Transcriptomics”
RNA-Seq transcriptome profiling of soleus from adult and aged mice following disuse muscle atrophy and recovery
Rodent hind limb unloading was used as a model for reduced muscle activity and eventual atrophy. After a 10 day period of unloading mice in this study were xe2 x80 x9creloaded xe2 x80 x9d for 3 days and regained use of their hind limbs. We report the application of Next-generation sequencing (NGS) technology for high-throughput profiling of mRNA in soleus muscle of adult (6 mo) and aged (22-24 mo) mice. Our goal was to determine the effects of hind limb unloading and reloading on mRNA profiles in soleus muscle and compare between adult and aged mice. We find that there are distinct response in the profile of fatty acid oxidation TCA cycle ETC oxidative phosphorylation gene expression patterns in response to unloading and reloading. The repsonses are generally simialr between young and old mice.
Rodent Research-1 (RR1) NASA Validation Flight: Mouse gastrocnemius muscle transcriptomic proteomic and epigenomic data
NASA s Rodent Research (RR) project is playing a critical role in advancing biomedical research on the physiological effects of space environments. Due to the limited resources for conducting biological experiments aboard the International Space Station (ISS) it is imperative to use crew time efficiently while maximizing high-quality science return. NASA s GeneLab project has as its primary objectives to 1) further increase the value of these experiments using a multi-omics systems biology-based approach and 2) disseminate these data without restrictions to the scientific community. The current investigation assessed viability of RNA DNA and protein extracted from archived RR-1 tissue samples for epigenomic transcriptomic and proteomic assays. During the first RR spaceflight experiment (RR-1) a variety of tissue types were harvested from subjects snap-frozen or RNAlater-preserved and then stored at least a year at -80C after return to Earth. They were then prioritized for this investigation based on likelihood of significant scientific value for spaceflight research. All tissues were made available to GeneLab through the bio-specimen sharing program managed by the Ames Life Science Data Archive and included mouse adrenal glands quadriceps gastrocnemius tibialis anterior extensor digitorum longus soleus eye and kidney. We report here protocols for and results of these tissue extractions and thus the feasibility and value of these kinds of omics analyses. In addition to providing additional opportunities for investigation of spaceflight effects on the mouse transcriptome and proteome in new kinds of tissues our results may also be of value to program managers for the prioritization of ISS crew time for rodent research activities.
Short-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction
GEO Series GSE52825. Mus musculus. 24 samples. Type: Expression profiling by array.
Vitamin D modulates cortical transcriptome in an Mecp2 heterozygous Rett syndrome mouse model
GEO Series GSE180630. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomes of Rice internode before and after heading
GEO Series GSE51289. Oryza sativa. 59 samples. Type: Expression profiling by array.
Transcriptomic Expression Profile Changes in Lung Tissue of Asthmatic Mice
GEO Series GSE295506. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of germinating maize kernels exposed to smoke-water and the active compound KAR1
GEO Series GSE17484. Zea mays. 68 samples. Type: Expression profiling by array.
Single Nuclei RNA Sequencing of the Gastrocnemius Muscle Reveals Unique Transcriptomic Signatures of Peripheral Artery Disease
GEO Series GSE233882. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency
GEO Series GSE260588. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling and digital gene expression analysis of sweet potato challenged with Fusarium oxysporum f. sp.batatas.
GEO Series GSE89290. Ipomoea batatas. 16 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic and phenotypic analysis reveals new functions for the Tat pathway in Yersinia pseudotuberculosis
GEO Series GSE80532. Yersinia pseudotuberculosis IP 32953; Yersinia pseudotuberculosis. 16 samples. Type: Expression profiling by array.
Transcriptome analysis of human periodontal ligament cells under tensile loading
GEO Series GSE173891. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Transcriptome changes in response to lead exposure
GEO Series GSE65334. Arabidopsis thaliana; Hirschfeldia incana. 12 samples. Type: Expression profiling by array.
Whole transcriptome analysis of brain hippocampal tissue from SAMP8 mice and rat primary neurons treated with the Alzheimer’s disease drug candidate CAD031
GEO Series GSE108776. Mus musculus; Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics [10X_scRNAseq]
GEO Series GSE141589. Drosophila melanogaster. 1 samples. Type: Expression profiling by high throughput sequencing.
The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [RNA-seq]
GEO Series GSE271385. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Diabetic Kidney Disease Induces Transcriptome Alterations Associated with Angiogenesis Activity in Human Mesenchymal Stromal Cells [mRNA]
GEO Series GSE217709. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
Long non-coding RNA and mRNA transcriptomic profiles after ischemia-reperfusion injury in rat spinal cord.
GEO Series GSE138966. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
The impact of iron depletion on the transcriptome of Enterococcus faecalis
GEO Series GSE221057. Enterococcus faecalis OG1RF. 6 samples. Type: Expression profiling by high throughput sequencing.
Phenotypically-anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish
GEO Series GSE80955. Danio rerio. 8 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.