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14,866
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14,866 results for “cancer cell”
Expression data from Ovarian cancer wild type cells (W1) and cells resisted to Cisplatin (W1CR)
GEO Series GSE140996. Homo sapiens. 8 samples. Type: Expression profiling by array.
Gene expression profiling of glucocorticoid receptor signaling in a prostate cancer epithelial cell lines (LNCaPabl-Abi, LNCaPabl-Enza)
GEO Series GSE150437. Homo sapiens. 12 samples. Type: Expression profiling by array.
Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics
GEO Series GSE160551. Homo sapiens. 4 samples. Type: Expression profiling by array.
Gene expession profiles of p16high and p16low adipocyte progenitor cells of gonadal adipose tissue in the cancer cachexia mouse model
GEO Series GSE264329. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Distant antimetastatic effect of enterotropic colon cancer-derived α4β7 CD8 T cells [3' single-cell RNA-seq]
GEO Series GSE193593. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Rerep-Seq of cadmium resistant breast cancer MDA-231 cells
GEO Series GSE165865. Homo sapiens. 12 samples. Type: Other.
TET1 knockdown cancer cell lines
GEO Series GSE121649. Homo sapiens. 8 samples. Type: Expression profiling by array; Methylation profiling by genome tiling array.
Tamarix Articulata Exhibits Antiproliferative and Antimetastatic Activity by Modulating PI3K/Akt-Mediated Downstream Signaling in Prostate Cancer Cells
<p>Supplementary material</p>
Evaluation of natural compounds from beetroot against cervical cancer cells HeLa
<p>The leaves and stems of beet (Beta vulgaris L.) are known to present higher total phenolic contents than the root. Some phenolic compounds present in beet, such as betaninas, quercetin and myricetin are potent agents that can reduce and/or inhibit oxidation of LDL cholesterol, reducing changes in endothelial structure. Besides, beetroot juice is used as a popular folk remedy for the treatment of liver and kidney diseases as well as for the stimulation of immune and haematopoietic systems. Here we aim to analyze the anti cancer effects of natural compounds derived from extracts from beet's roots and leaves, including betanin and apigenin, in the cell line derived from human carcinoma of uterus, HeLa. After treatment of HeLa cancer cells, proliferation, migration, cell cycle, apoptosis and mTOR pathway status will be evaluated.</p> <p>This dataset was already published: 10.1002/ptr.7255</p>
FAM83B is involved in thyroid cancer cell differentiation and migration
<p>FAM83B has been recently identified as an oncogene, but its role in thyroid cancers (TC) is still unclear. We examined the expression of FAM83B and its possible involvement in cell migration and differentiation, in neoplastic/normal thyroid tissues and in TC human cell lines. FAM83B expression in TC varies according to the tumor histotype, being significantly downregulated in more aggressive and metastatic tissues. FAM83B levels in cell lines recapitulate patients' samples variations, and its total and cytoplasmic levels decrease upon the induction of migration, together with an increase in its nuclear localization. Similar variations were detected in the primary tumor and in the metastatic tissues from a follicular TC. FAM83B knock down experiments confirmed its role in thyroid differentiation and cell migration, as demonstrated by the reduction of markers of thyroid differentiation and the increase of the mesenchymal marker vimentin. Moreover, the silencing of FAM83B significantly increased cells migration abilities, while not affecting the oncogenic RAS/MAPK/PI3K pathways. Our data indicate for the first time a role for FAM83B in TC cell differentiation and migration. Its expression is reduced in dedifferentiated tumors and its nuclear re-localization could favour distant migration, suggesting that FAM83B should be considered a possible diagnostic and prognostic biomarker.</p>
RNA sequencing data from breast precancerous and cancerous cells - Part1/3
<p>RNA sequencing data (fastq files) from breast precancerous and cancerous cell lines (total of 12 cell lines) as described in the paper entitled "CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse" by Taouk et al.</p> <p>The file name is "sample number_replicate number_overall sample number_read direction_001", where:</p> <p>- Sample number: represents the cell line (can be determined from supplementary figures 1, 3 and 5 of the above mentioned paper).</p> <p>- Replicate number: RNA from two independent experiments for each cell line (1 is for first replicate and 2 for the second replicate).</p> <p>- Overall sample number: random numbers given for all samples</p> <p>- Read direction: R1 (forward), R2 (reverse)</p> <p>This dataset (part1/3) contains fastq files for samples 1 to 4.</p>
RNA sequencing data from breast precancerous and cancerous cells - Part2/3
<p>RNA sequencing data (fastq files) from breast precancerous and cancerous cell lines (total of 12 cell lines) as described in the paper entitled "CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse" by Taouk et al.</p> <p>The filename is "sample number_replicate number_overall sample number_read direction_001", where:</p> <p>- Sample number: represents the cell line (can be determined from supplementary figures 1, 3 and 5 of the above mentioned paper).</p> <p>- Replicate number: RNA from two independent experiments for each cell line (1 is for first replicate and 2 for the second replicate).</p> <p>- Overall sample number: random numbers given for all samples</p> <p>- Read direction: R1 (forward), R2 (reverse)</p> <p>This dataset (part2/3) contains fastq files for samples 5 to 8.</p>
Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression
<p><span><span>While cancer-associated fibroblasts (CAFs) are crucial in influencing tumor growth and immune responses in lung cancer, we still lack a comprehensive understanding of their spatial organization associated with tumor progression and clinical outcomes. This gap highlights the need to elucidate how the intricate spatial arrangement of CAFs affects their interactions within the tumor microenvironment, ultimately shaping cancer progression and patient prognosis. Here, we unveil the spatial diversity of CAFs in lung squamous cell carcinoma (LUSC), a prevalent and aggressive lung cancer type, elucidating their impact on tumor progression and patient outcomes using spatial transcriptomics (ST). Image-based ST data from 33 LUSC patients demonstrated a significant association of spatial interactions of tumor epithelium and CAFs with tumor size and metabolic activity measured by [<sup>18</sup>F]fluorodeoxyglucose PET. Furthermore, the proximity of fibroblasts to tumor epithelial cells was linked to recurrence-free survival in LUSC patients. By characterizing CAFs based on their spatial relationship, we identified distinct molecular signatures related to spatially distinct fibroblast subpopulations. In addition, barcode-based ST data from 8 LUSC patients revealed spatially overlapping fibroblast regions characterized by upregulated glycolysis pathways. </span></span><span><span><span><span>Our study underscores the importance of the complex spatial dynamics of the tumor microenvironment revealed by ST and its implications for patient outcomes in LUSC.</span></span></span></span></p>
The analysis of differentially expressed genes relevant to glycolysis in hypoxia-treated gastric cancer cells
<p> RNA sequencing was conducted to identify hypoxia-altered genes in GC cells. A total of 13,469 genes were included, with 430 genes upregulated and 476 genes downregulated. Gene Ontology (GO) analysis indicated that hypoxia-regulated genes mainly focused in glycolysis and canonical glycolysis pathways. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that hypoxia-regulated genes were significantly correlated with glycolysis pathway.</p>
Source data for the article of AFM-based multifaceted mechanoproperty characterisation of cancer cells with a fluid-containing porous medium model
<p>Source data for the article of AFM-based multifaceted mechanoproperty characterisation of cancer cells with a fluid-containing porous medium model</p>
Dataset related to article "Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I"
<p>This record contains raw data (metabolomic and RNASeq data) related to the article: "Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I"</p>
RNA sequencing data from breast precancerous and cancerous cells - Part3/3
<p>RNA sequencing data (fastq files) from breast precancerous and cancerous cell lines (total of 12 cell lines) as described in the paper entitled "CD56 expression in breast cancer induces sensitivity to natural killer-mediated cytotoxicity by enhancing the formation of cytotoxic immunological synapse" by Taouk et al.</p> <p>The filename is "sample number_replicate number_overall sample number_read direction_001", where:</p> <p>- Sample number: represents the cell line (can be determined from supplementary figures 1, 3 and 5 of the above mentioned paper).</p> <p>- Replicate number: RNA from two independent experiments for each cell line (1 is for first replicate and 2 for the second replicate).</p> <p>- Overall sample number: random numbers given for all samples</p> <p>- Read direction: R1 (forward), R2 (reverse)</p> <p>This dataset (part3/3) contains fastq files for samples 9 to 12.</p>
TARGET: Cancer Model Systems (MDLS): Cell Lines and Xenografts (including PPTP)
Open the record for dataset details and reuse information.
MALAT1 induces cell apoptosis by targeting and stabilizing BCL2L2 mRNA in colorectal cancer
<p>Raw data </p>
Intrinsic gene profiles in patients with non–small cell lung cancer
<p><strong>Intrinsic gene profiles in patients with non–small cell lung cancer</strong></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.