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3,361 results for “Randomized Controlled Trial”
Data from: The effect of promoting current local research activities on large monitors on the population's interest in health-related research – a randomized controlled trial
OBJECTIVE: The objectives of this study were threefold: to estimate people's interest in health-related research, to understand to what extent people appreciate being actively informed about current local health-related research and to investigate whether their interest can be influenced by advertising local current health-related research using large TV monitors. DESIGN: Randomized controlled trial using a stepped wedge design. SETTING: The emergency department waiting room at two public hospitals in northern Queensland, Australia. PARTICIPANTS: Waiting patients and their accompanying friends and relatives in the emergency department waiting room not requiring immediate medical attention. INTERVENTIONS: A TV monitor advertising local current health-related research. MAIN OUTCOME MEASURES: Odds ratio for the effect of intervention on changing the interest in health-related research compared to a control group while adjusting for gender, age and socioeconomic standard. RESULTS: The intervention significantly increased the short-term interest in health-related research with an odds ratio of 1.3 (1.1-1.7, p=0.0063). We also noted that being female and being older was correlated to a higher interest in health-related research CONCLUSIONS: This study found that proactive information significantly increased the general populations' interest in health-related research. There are reasonable set up costs involved but the costs for maintaining the system were very low. Hence, it seems reasonable that research-active organizations should give much higher priority to this type of activity. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ANZCTR) with the registration number ACTRN12617001085369
Data from: Are multiple views superior to a single view when teaching hip surgery? a single-blinded randomized controlled trial of technical skill acquisition
Purpose: Surgical education videos currently all use a single point of view (POV) with the trainee locked onto a fixed viewpoint, which may not deliver sufficient information for complex procedures. We developed a novel multiple POV video system and evaluated its training outcome compared with traditional single POV. Methods: We filmed a hip resurfacing procedure performed by an expert attending using 8 cameras in theatre. 30 medical students were randomly and equally allocated to learn the procedure using the multiple POV (experiment group [EG]) versus single POV system (control group [CG]). Participants advanced a pin into the femoral head as demonstrated in the video. We measured the drilling trajectories and compared it with pre-operative plan to evaluate distance of the pin insertion and angular deviations. Two orthopedic attendings expertly evaluated the participants' performance using a modified global rating scale (GRS). There was a pre-video knowledge test that was repeated post-simulation alongside a Likert-scale questionnaire. Results: The angular deviation of the pin in EG was significantly less by 29% compared to CG (p=0.037), with no significant difference in the entry point's distance between groups (p=0.204). The GRS scores for EG were higher than CG (p=0.046). There was a 32% higher overall knowledge test score (p<0.001) and 21% improved Likert-scale questionnaire score (p=0.002) after video-learning in EG than CG, albeit no significant difference in the knowledge test score before video-learning (p=0.721). Conclusion: The novel multiple POV provided significant objective and subjective advantages over single POV for acquisition of technical skills in hip surgery.
Data from: Assessment of the quality of reporting in randomized controlled trials of acupuncture in the Korean literature using the CONSORT statement and the STRICTA guidelines
Objectives: This study aimed to assess the completeness of reporting of RCTs of acupuncture in the Korean literature. Design: Systematic review. Methods: We searched 12 Korean databases and 7 Korean journals to identify eligible RCTs of acupuncture published from 1996 to July 2011. We used the Consolidated Standards of Reporting Trials (CONSORT) checklist for parallel RCTs and the revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) to assess the quality of reporting in Korean RCTs. We compared the completeness of reporting of CONSORT and STRICTA items in RCTs published in two time periods (1996-2004 referred to as the early period and 2005-2011 referred to as the late period). Results: We analysed 146 eligible RCTs using the CONSORT statement concerning RCTs of both needling and non-needling acupuncture and the STRICTA guidelines for 90 trials of needling acupuncture. Among the 103 RCTs in the late period, the proportion of RCTs that completely reported the CONSORT items of outcome definition (15.5%), sample size calculation (2.9%), randomisation (56%), allocation concealment (5.8%), implementation of allocation (11.7%), outcome assessor blinding (20.3%), flow of participants (25.2%), number of participants analysed (19.4%), ancillary analyses (0.0%), adverse events (24.3%), generalisability of findings (1.9%) and overall evidence (32.0%) remained small. Among the 61 RCTs of needling acupuncture in the late period, the STRICTA items of setting/context (24.6%) and practitioner background (27.9%) showed incomplete reporting. The completeness of reporting improved over time in several CONSORT and STRICTA items. Conclusion: The completeness of reporting of Korean RCTs of acupuncture was suboptimal according to the CONSORT and revised STRICTA statements. Trial authors and journal editors should use the CONSORT statement and the STRICTA guidelines for transparent reporting in Korean RCTs of acupuncture. The endorsement of the CONSORT and revised STRICTA statements in author instructions is also required.
Data from: Ginkgo biloba extract for prevention of acute mountain sickness: a systematic review and meta-analysis of randomized controlled trials
Study objective: Trials of ginkgo biloba extract (GBE) for the prevention of acute mountain sickness (AMS) have been published since 1996. Because of their conflicting results, the efficacy of GBE remains unclear. We performed a systematic review and meta-analysis to assess whether GBE prevents acute mountain sickness. Methods: The Cochrane Library, EMBASE, Google Scholar, and PubMed databases were searched for articles published up to May 20, 2017. Only randomized controlled trials were included. AMS defined as acute mountain sickness–cerebral(AMS-C) score≧0.7 or Lake Louise Score (LLS)≧3 with headache. The main outcome measures were the relative risks of AMS in participants receiving GBE for prophylaxis. Meta-analyses were conducted using random-effects models. Sensitivity analyses, subgroup analyses and tests for publication bias were conducted. Results: Six published articles with a total of 451 participants met all eligibility criteria. In the primary meta-analysis of all 7 study groups, GBE showed trend of AMS prophylaxis, but it is not statistically significant (RR =0.68; 95% CI: 0.45 to 1.04; p-value=0.08) (Figure 2). The I2 statistic was 58.7% (p-value=0.02), indicating substantial heterogeneity. The results of subgroup analyses of studies with low risk of bias, low starting altitude (<2500 m), number of treatment days before ascending and dosage of GBE were similar. Conclusions: The currently available data suggest that although GBE may tend toward AMS prophylaxis, there are not enough data to show the statistically significant effect of GBE for preventing AMS. Further large randomized control studies are warranted.
Effectiveness of Facility-Based Personalized Maternal Nutrition Counseling in Improving Child Growth and Morbidity up to 18 Months: A Cluster-Randomized Controlled Trial in Rural Burkina Faso.
<p>"Baseline Characteristics.dta": give data on participants first sociodemographic caracteristics and outcome collected during the first follow_up visit.</p> <p>"Follow-up Data.dta": Provide data on all the follow-up visits"</p>
Anticoagulant and anti-inflammatory effects of fondaparinux sodium in anterior cruciate ligament reconstruction in patients at high risk of VTE: A Randomized Controlled Trial
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Tongue cleaning enhances the myoelectric activity of the suprahyoid muscles in older adults: A six-week randomized controlled trial
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To swim or not to swim after eating: a randomized controlled crossover feasibility trial
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Suplementary Files-Effect of Post-Extubation Inspiratory Muscle Training on Diaphragmatic Function in Mechanically Ventilated Patients: A Randomized Controlled Trial
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raw data - Effects of preemptive acupuncture on cognitive function of the elderly patients after hip replacement: a randomized controlled trial
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The impact of sleep hygiene education and lavender essential oil inhalation on the sleep quality and overall well-being of athletes who undergo late-evening training: a randomized controlled trial
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STRICTA Check list for Effects of Electroacupuncture on Cognitive Symptoms in Major Depressive Disorder: A Pilot Study and Randomized Controlled Trial
<p>STRICTA 2010 check list</p>
Feasibility of a Randomized Controlled Trial of Large Artificial Intelligence-Based Linguistic Models for Clinical Reasoning Training of Physical Therapy Students.
<p>Data collected for students who participated in the study</p>
The effect of a 6-month tablet-based multimodal training for cognitive functioning in Alzheimer's disease in a randomized controlled trial
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Evaluation of Clinical application of sclerotherapy combined with oral sirolimus in the treatment of tongue microcystic lymphatic malformation in children:A Randomized Controlled Trial
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Data from: 8-way randomized controlled trial of doxylamine, pyridoxine and dicyclomine for nausea and vomiting during pregnancy: restoration of unpublished information
Objectives: We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy. We are publishing the trial's findings according to the restoring invisible and abandoned trials (RIAT) initiative because the trial was never published. Design: Double blinded, multi-centred, randomized placebo-controlled study. Setting: 14 clinics in the United States. Participants: 2308 patients in the first 12 weeks of pregnancy with complaints of nausea or vomiting were enrolled. Interventions: Each patient was randomized to one of eight arms: placebo, doxylamine/pyridoxine/dicylcomine, doxylamine/pyridoxine, dicylomine/pyridoxine, doxylamine, dicyclomine/pyridoxine, pyridoxine and dicyclomine. Each patient was instructed to take 2 tablets at bedtime and 1 additional tablet in the afternoon or morning if needed, for 7 nights. Outcomes: Reported outcomes included the number of hours of nausea reported by patients, the frequency of vomiting reported by patients and the overall efficacy of medication as judged by physicians. Results: Data from 1599 (69% of those randomized) participants were analyzed. Based on the available summary data of physician evaluation of symptoms and ignoring missing data and data integrity issues, the proportion of participants who were "evaluated moderate or excellent" was greater in each of the seven active treatment groups when compared with placebo (57%): doxylamine/pyridoxine/dicylcomine (14% absolute difference versus placebo; 95% CI: 4 to 24), doxylamine/pyridoxine (21; 95% CI 11 to 30), dicylomine/pyridoxine (21; 95% CI 11 to 30), doxylamine (20; 95% CI 10 to 29), dicyclomine/pyridoxine (4; 95% CI -6 to 14), pyridoxine (9; 95% CI -1 to 19) and dicyclomine (4; 95% CI -6 to 14). Based on incomplete information, the most common adverse events were apparently drowsiness and fatigue. There is a high risk of bias in these previously unpublished results given the high attrition rate in a 7 day trial, the lack of prespecified outcomes or analyses, and the exclusion of some data because of questionable data integrity. Conclusion: The available information about this "8-way Bendectin" trial indicates it should not be used to support the efficacy of doxylamine, pyridoxine or dicyclomine for the treatment of nausea and vomiting during pregnancy because of a high risk of bias.
Effects of supervised exercise training during pregnancy on psychological well-being among overweight and obese women: Secondary analyses of the ETIP-trial, a randomized controlled trial.
<p><b>Objectives: </b>Women with high body mass index (BMI) have increased risk for symptoms of anxiety and depression during pregnancy and postpartum. In this pre-specified secondary analysis from the ETIP trial, our aim was to examine effects of supervised exercise during pregnancy on psychological well-being in late pregnancy and postpartum among women with a pre-pregnancy BMI ≥ 28 kg/m<sup>2</sup>.</p> <p><b>Design: </b>Single-centre, parallel group, randomized controlled trial.</p> <p><b>Setting: </b>University Hospital, Norway</p> <p><b>Participants: </b><a name="_Hlk10799837">Ninety-one women (age 31.2±4.1 years, BMI 34.5±4.2 kg/m<sup>2</sup>), 46 in the exercise group, 45 in the control group, were included in the trial. </a></p> <p><b>Intervention:</b> The exercise group was offered three weekly supervised exercise sessions (35 minutes of moderate intensity walking/running and 25 minutes of resistance training), until delivery.</p> <p><b>Primary and secondary outcomes measures:</b> Primary analyses were based on intention to treat, with secondary per-protocol analyses. To assess psychological well-being, we used the «Psychological General Well-Being Index» (PGWBI) at inclusion (gestational week 12-18), late pregnancy (gestational week 34-37), and three months postpartum. We assessed postpartum depression using the «Edinburgh Postnatal Depression Scale» (EDPS).</p> <p><b>Results:</b> Numbers completed data collection: Late pregnancy 72 (exercise 38, control 36), postpartum 70 (exercise 36, control 34). In the exercise group, 50% adhered to the exercise protocol. Baseline PGWBI for all women was 76.4±12.6. Late pregnancy PGWBI; exercise 76.6 (95% CI 72.2, 81.0), control 74.0 (95% CI 69.4, 78.5) (<i>p</i> = 0.42). Postpartum PGWBI; exercise 85.4 (95% CI 81.9, 88.8), control 84.6 (95% CI 80.8, 88.4) (with no between-group difference, <i>p</i> = 0.77). There was no between-group difference in EDPS; exercise 2.96 (95% CI 1.7, 4.2), control 3.48 (95% CI 2.3, 4.7) (<i>p</i> = 0.55).</p> <p><b>Conclusions: </b>We found no effect of supervised exercise during pregnancy on psychological well-being among women with high BMI. Our findings may be hampered by low adherence to the exercise protocol.</p>
Data from: An investigation of the therapeutic effects of statins with metformin on polycystic ovary syndrome: a meta-analysis of randomized controlled trials
Objectives: To investigate the therapeutic effects of statins with metformin on polycystic ovary syndrome (PCOS). Settings: Endocrinology department. Participants: MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials were searched until October 2014. Studies comparing statins and placebo, as well as the combination of statins and metformin and metformin alone, were included in the analysis. Interventions: Data were independently extracted by two researchers; any convergence was resolved by a third reviewer. Primary and secondary outcome measures: The following properties were extracted from the qualified trials to identify the effects of statins: clinical variables, metabolic characteristics, hormone outcomes, sign of inflammation, glucose parameters and insulin outcomes. Results: Data from four trials comparing statin and metformin with metformin alone were analysed. The combination of statins and metformin decreases the levels of C reactive protein (standardised mean difference (SMD) −0.91; 95% CI −1.81 to −0.02; p=0.046), triglyceride (SMD −1.37; 95% CI −2.46 to −0.28; p=0.014), total cholesterol (SMD −1.28; 95% CI −1.59 to −0.97; p=0.000) and low-density lipoprotein (LDL) cholesterol (SMD −0.74; 95% CI −1.03 to −0.44; p=0.000). However, the combined therapy fails to reduce fasting insulin (SMD −0.92; 95% CI −2.07 to 0.24; p=0.120), homeostasis model assessment of insulin resistance (SMD −1.15; 95% CI −3.36 to 1.06; p=0.309) and total testosterone (SMD −1.12; 95% CI −2.29 to 0.05; p=0.061). Analysis of the five trials comparing statin with placebo shows that statin monotherapy reduces LDL-cholesterol, triglyceride and total cholesterol. Conclusions: Combined statin and metformin therapy can improve lipid and inflammation parameters, but cannot effectively improve insulin sensitivity and reduce hyperandrogenism in women with PCOS. A large-scale randomised controlled study must be conducted to ascertain the long-term effects of the therapy.
Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases
<p><strong>Supplementary Dataset 1. </strong>Select ClinicalTrials.Gov data fields for the RCT studies identified as the<br> <em>main </em>dataset.<br> <strong>Supplementary Dataset 2.</strong> Select ClinicalTrials.Gov data fields for the RCT studies identified as the<br> <em>literature </em>dataset.<br> <strong>Supplementary Dataset 3.</strong> Comparison of frequency of RCT general features between the <em>Main</em><br> dataset and background of all RCTs available in ClinicalTrials.Gov.</p> <p><strong>Supplementary Dataset 4. </strong>PubMed and SemMedDB data for published MR and RCT studies.<br> <strong>Supplementary Dataset 5. </strong>Case series of MR and RCT studies with matching exposures<br> (interventions) and outcomes (conditions).</p>
Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial
ClinicalTrials.gov study NCT04593160. IPD Sharing: Not stated. Countries: 0. Publications: 3.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.