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Dataset related to article "Volumetric Modulated Arc Therapy After Lung Sparing Surgery for Malignant Pleural Mesothelioma: A Single Institution Experience."
<p>INTRODUCTION:</p> <p>We investigated the possible role of volumetric modulated arc therapy (VMAT) in the setting of adjuvant treatment of malignant pleural mesothelioma (MPM) after lung-sparing surgery with pleurectomy and decortication.</p> <p>MATERIALS AND METHODS:</p> <p>Patients affected by MPM who had undergone pleurectomy and decortication and adjuvant radiotherapy with VMAT were included. The endpoints of the present analysis were local control, progression-free survival, and overall survival. Assessment of the variables affecting survival was performed using univariate and multivariate Cox proportional hazard models.</p> <p>RESULTS:</p> <p>A total of 49 patients were included in the present study. Of the 49 patients, 96% had been treated with a trimodality approach. Radiotherapy was delivered to a median dose of 44 Gy in 22 fractions (range, 22-59.4 Gy). The treatment was well tolerated, with just 2 grade 3 acute toxicities, 1 grade 5, and 2 grade 4 toxicities recorded during the follow-up period. The median follow-up period was 27.4 months. The local control rate at 12, 24, and 36 months was 75.2%, 67.4%, and 56.5%, respectively. The median progression-free survival was 14.9 months (95% confidence interval [CI], 7.5-25.2). The median overall survival was 21.5 months (95% CI, 15.3-37.1). On multivariate analysis, the administration of carboplatin- instead of cisplatin-based chemotherapy (hazard ratio, 2.97; 95% CI, 1.22-7.26; P = .017) and R2 resection (hazard ratio, 1.95; 95% CI, 1.27-2.99; P = .002) showed a negative correlation with overall survival. On univariate analysis, the percentage of the heart receiving >20 Gy and >30 was associated with the occurrence of late pneumonitis (P = .018 and P = .077).</p> <p>CONCLUSION:</p> <p>VMAT is feasible in the setting of MPM after lung-sparing surgery. The toxicity rates were reduced with this technique compared with historical data of older techniques. Local and distant failure remain a major issue to be addressed in future trials.</p>
Dataset related to article "Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a multi-institutional analysis."
<p>PURPOSE:</p> <p>For patients with oligometastatic/oligorecurrent/oligoprogressive lymph node metastases from PCa, metastases-directed therapy is an emerging strategy. The aim of this retrospective study was to evaluate the oncological outcome and pattern of recurrence in patients treated with stereotactic body radiation therapy (SBRT) to lymph node metastases.</p> <p>METHODS:</p> <p>In this multi-institutional analysis, patients with a maximum of five lymph node metastases from PCa treated with SBRT were included. Primary endpoints of the analysis were local control (LC), out-of-field nodal progression-free survival (NPFS), overall progression-free survival (PFS), and overall survival (OS).</p> <p>RESULTS:</p> <p>109 patients and 155 lymph node metastases were evaluated. Patients' median age was 70.8 years (range 51-84) and median PSA before SBRT was 1.88 ng/ml (range 0.3-45.5 ng/ml). The dose delivered to the target ranged from 25 to 48 Gy in 4-7 fractions; median BED<sub>1.5</sub> <sub>Gy</sub> was 198 Gy (range 108.3-432 Gy). With a median follow-up of 16 months, LC rates at 1 and 3 years were 93% and 86%, respectively. In-field progression of disease was observed in 11 (7%) lesions. One- and 3‑year NPFS was 59% and 29%, and median NPFS was 15 months. Rates of OS at 1 and 3 years were 100% and 95%. The median time to administration of a systemic treatment after SBRT was 7.8 months (1.7-54.8).</p> <p>CONCLUSION:</p> <p>SBRT is an effective and well-tolerated treatment option in the management of lymph node metastases from PCa. Prospective trials are necessary to better select patients who benefit most from this ablative focal treatment and better define the recurrence patterns.</p>
Dataset related to article "Nivolumab in disadvantaged subgroups of metastatic non-small-cell lung cancer patients: a single-institution experience."
<p><strong>Aim:</strong> Immunotherapy opened new frontiers in metastatic non-small-cell lung cancer treatment, but not all patients benefit from it. <strong>Methods:</strong> We retrospectively evaluated 65 metastatic non-small-cell lung cancer patients, treated with nivolumab, considering as disadvantaged subgroups those with poor performance status, elderly, patients with brain metastases at baseline, with high disease burden and refractory to platinum. <strong>Results:</strong> No differences in overall survival or time to treatment failure were found according to performance status, age, presence of brain metastases at baseline or high disease burden. Conversely, patients refractory to platinum had a statistically significant shorter overall survival and time to treatment failure. At multivariate analysis only platinum resistance was confirmed as an independent predictive factor. <strong>Conclusion:</strong> Our study suggests that only refractoriness to platinum salts influence the efficacy of nivolumab.</p>
Dataset related to article "Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"
<p>This record contains raw data related to article “Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"</p> <p><strong>Introduction: </strong>Biliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC).</p> <p><strong>Materials and methods: </strong>We retrospectively analyzed clinical outcomes for a cohort of mBTC patients treated with SBRT for oligometastatic disease. Inclusion criteria were 1-5 distant metastases; SBRT with a dose/fraction of a least 5 Gy to a biological effective dose (BED) of at least 40 Gy considering an α/β of 10 Gy. Analyzed outcomes included local control (LC), distant progression-free survival (DPFS), PFS, and OS.</p> <p><strong>Results: </strong>51 patients meeting the inclusion criteria. Primary tumor sites were intrahepatic cholangiocarcinoma (35%), extrahepatic cholangiocarcinoma (31%), ampullary adenocarcinoma (20%), gallbladder adenocarcinoma (14%). 21 patients were treated on liver lesions, 17 on nodal metastasis, 5 patients on lung lesions, 4 patients on recurrence along the extrahepatic bile duct. After a median follow-up of 14 months median OS was 13.7 months, 1- and 2-year OS were 58% and 41%, respectively. Node and lung as metastatic sites were associated with a longer OS (p < 0.001). Median LC was 26.8 months, and intrahepatic cholangiocarcinoma was associated with longer LC (p = 0.036). Median DPFS was 11 months, with 1- and 2-year DPFS of 48% and 27.8%, respectively. Ten patients reported grade 1-2 toxicity and 2 cases of acute G3 biliary obstruction.</p> <p><strong>Conclusions: </strong>Stereotactic body radiotherapy (SBRT) is feasible in the context of mBTC. OS and PFS results are promising, considering that our patients were heavily pre-treated with systemic therapy. Patients with nodal or lung relapse have better prognosis. Distant relapses remain the main pattern of failure, but treatment of all metastatic sites seems to improve DMFS.</p>
Dataset related to article "Long term follow up in 183 high grade meningioma: A single institutional experience"
<p>Database contains epidemiological, diagnostic, therapeutic, recurrence information and survival data of HGM treated at our institution between 2010 and 2018.</p>
Dataset related to article "Surgical management of BRCA-mutation carriers: A single institution experience"
<p>This record contains raw data related to article “Surgical management of BRCA-mutation carriers: A single institution experience"</p> <p>Abstract:</p> <p><strong>Introduction: </strong> The optimal surgical management of BRCA-mutation carriers remains a subject of debate. To evaluate the appropriateness of breast cancer (BC) treatment, the oncological outcomes of BRCA-mutation carriers treated either with breast-conserving therapy (BCT) or mastectomy were compared. Additionally, the role of bilateral salpingo-oophorectomy (BSO) and potential independent predictive factors for BC treatment were analyzed.</p> <p><strong>Materials and methods: </strong> We retrospectively reviewed all the consecutive patients with a pathogenic germline mutation in the BRCA1/2 genes tested at our Institution between July 2008 and October 2018. Primary end-points were disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS).</p> <p><strong>Results: </strong> The characteristics and outcomes of 124 BRCA-associated BC patients were analyzed. Overall, 69 (55.7%) and 55 (44.3%) patients underwent BCT and mastectomy, respectively; 72 (58.1%) patients underwent BSO. After a median interval of 13.3 months, 24 patients underwent mastectomy after primary BCT. There was no significant difference in terms of DFS, DDFS, and OS between patients treated with BCT or mastectomy (p = 0.39,p = 0.27,p = 0.265, respectively). Patients treated with BSO had significantly better DDFS and OS compared to ovarian conservation (p = 0.033,p = 0.040, respectively). Three independent predictive factors for BCT were identified: age ≤41 years, genetic testing performed post-operatively, and breast tumors ≤21 mm.</p> <p><strong>Conclusions: </strong> Our data suggest that BRCA-mutation carriers treated with BCT present similar oncological outcomes compared to mastectomy. Ovarian preservation decreases survival. Young BRCA-mutated patients with small BCs may not need up-front mastectomy, and BSO might be performed when ovarian cancer risk epidemiologically rises and potential reproductive desire is fulfilled.</p>
IBAIRN data (Boreal forest, Hyytiälä Sept. 2016) Max-Planck-Institut, Mainz
<p>Time series (10 min averages) of trace gases measured by the Max-Planck-Institut für Chemie during the IBAIRN-campaign. </p>
Massenentsäuerung im Ibero-Amerikanischen Institut - Preußischer Kulturbesitz
Die Bibliothek des Ibero-Amerikanischen Instituts der Stiftung Preußischer Kulturbesitz in Berlin (IAI) ist mit uber 830.000 Monografien, 33.000 Zeitschriften und Zeitungen, von denen ca. 5.000 als laufende Abos gefuhrt werden, und zahlreichen weiteren groBen Sondersammlungen (Landkarten,Tontrager, Videos, DVDs, Nachlasse etc.) die größte Spezialbibliothek zu Lateinamerika, Spanien, Portugal und der Karibik in Europa und nach der Library of Congress in Washington und der Nettie-Lee-Benson-Collection der University of Texas in Austin die drittgrößte Spezialbibliothek dieser Art in der Welt. Über Kauf, Tausch und Schenkung erweitert sich der Bestand jedes Jahr um ca. 30.000 Monografien. Um die Nachweissituation von Sammelband- und Zeitschriftenaufsätzen und gleichzeitig das bibliografische Informationsangebot im Sinne einer Spezialbibliothek zu verbessern, führt das IAI seit 2008 ein Projekt unter Einsatz von MyBib eDoc® und C-3-Periodakaserver durch.
Dataset related to article "Robotic surgery, video-assisted thoracic surgery, and open surgery for early stage lung cancer comparison of costs and outcomes at a single institute"
<p>This record contains raw data related to article "Robotic surgery, video-assisted thoracic surgery, and open surgery for early stage lung cancer comparison of costs and outcomes at a single institute"</p> <p>Background:</p> <p>Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared costs and outcomes for robotic surgery, video-assisted thoracic surgery (VATS), and open surgery, to treat non-small cell lung cancer (NSCLC).</p> <p>Methods:</p> <p>We retrospectively assessed 103 consecutive patients given lobectomy or segmentectomy for clinical stage I or II NSCLC. Three surgeons could choose VATS or open, the fourth could choose between all three techniques. Between-group differences were assessed by Fisher's exact, two-way analysis of variance (ANOVA), and Wilcoxon-Mann-Whitney test. P values <0.05 were considered significant.</p> <p>Results:</p> <p>Twenty-three patients were treated by robot, 41 by VATS, and 39 by open surgery. Age, physical status, pulmonary function, comorbidities, stage, and perioperative complications did not differ between the groups. Pathological tumor size was greater in the open than VATS and robotic groups (P=0.025). Duration of surgery was 150, 191 and 116 minutes, by robotic, VATS and open approaches, respectively (P<0.001). Significantly more lymph node stations were removed (P<0.001), and median length of stay was shorter (4, 5 and 6 days, respectively; P<0.001) in the robotic than VATS and open groups. Estimated costs were 82%, 68% and 69%, respectively, of the regional health service reimbursement for robotic, VATS and open approaches.</p> <p>Discussion:</p> <p>Robotic surgery for early lung cancer was associated with shorter stay and more extensive lymph node dissection than VATS and open surgery. Duration of surgery was shorter for robotic than VATS. Although the cost of robotic thoracic surgery is high, the hospital makes a profit.</p>
FIGURE 10. Paralichthys olivaceus var. coreanicus. Syntypes ZIN 12378 in Annotated catalogue of type specimens of flatfishes (Osteichthyes: Pleuronectiformes) in the Zoological Institute, St. Petersburg, Russia
FIGURE 10. Paralichthys olivaceus var. coreanicus. Syntypes ZIN 12378.
FIGURE 23. Samaris chesterfieldensis. Paratype ZIN 55367 in Annotated catalogue of type specimens of flatfishes (Osteichthyes: Pleuronectiformes) in the Zoological Institute, St. Petersburg, Russia
FIGURE 23. Samaris chesterfieldensis. Paratype ZIN 55367, photo—(A) and radiograph (B).
FIGURE 1. Arnoglossus kessleri. Syntypes ZIN 18861 in Annotated catalogue of type specimens of flatfishes (Osteichthyes: Pleuronectiformes) in the Zoological Institute, St. Petersburg, Russia
FIGURE 1. Arnoglossus kessleri. Syntypes ZIN 18861, photo—(A) and radiograph (B); ZIN 18862 (C)
Identifying Key Factors Influencing the Interpreting Teaching in China's Higher Education Institutions: A Delphi Study
<p>Round 1 Delphi data for "Identifying Key Factors Influencing the Interpreting Teaching in China’s Higher Education Institutions: A Delphi Study"</p> <p> </p>
Feasibility of peak temperature targets in light of institutional constraints
<h1><strong>Download information: </strong><strong>Please do not request a data download here.</strong></h1> <p>Rather, the data is available for download at the <a href="https://data.ece.iiasa.ac.at/engage">ENGAGE Scenario Explorer</a> under this <strong>download link:</strong> <a href="https://data.ece.iiasa.ac.at/engage/#/downloads">https://data.ece.iiasa.ac.at/engage/#/downloads</a>. In order to download click on <em>Guest login. </em>You will be forwarded to the downloads page. At the <strong>bottom</strong> of the <strong>downloads</strong> page you can download the data under the name: <em><strong>ENGAGE Feasibility of peak temperature targets in light of institutional constraints (DOI: 10.5281/zenodo.11562539)</strong></em>.</p> <p>The license permits use of the scenario ensemble for scientific research and commercial use, but restricts redistribution of substantial parts of the data. Please refer to the FAQ and <a href="https://data.ece.iiasa.ac.at/engage/#/license">legal code</a> for more information.</p> <h2>Data set description</h2> <p>This data set includes global climate change mitigation scenarios as summarized by <a href="https://doi.org/10.1038/s41558-024-02073-4" target="_blank" rel="noopener">Bertram et al., 2024</a>. The scenarios are developed as part of the <a href="http://www.engage-climate.org/" target="_blank" rel="noopener">ENGAGE</a> project, and explore a wide set of dedicated feasibility assumptions along the institutional, technological, geophysical, and socio-cultural dimensions. In terms of mitigation ambition, the study follows the "net-zero budget" approach from <a href="https://www.nature.com/articles/s41558-021-01215-2" target="_blank" rel="noopener">Riahi et al. 2021</a> and contrasts both a below 2°C scenario (defined as 1000 Gt CO2 from 2018 until reaching net-zero CO2 emissions globally), and a scenario exploring the lowest possible peak temperature (aiming for a 550 Gt CO2 net-zero budget). </p> <h3><strong>Author Contributions</strong></h3> <p>C.B., E.B. and K.R. designed the study with input by L.D., E.K., G.L., B.v.R., R.S., D.v.V. and Z.V.; E.B. and C.B. prepared the governance input data for the IAMs; C.B., E.B., L.D., B.v.R., L.A.R., L.B.B., H.-S.d.B., V.D., F.F., D.F., O.F., S.F., K.K., V.K., R.M., P.R., R.S., D.S., I.T. and Z.V. produced the IAM scenario results; R.C., G.I. and N.H. provided a review of results and framing; R.D.L. and J.R. provided temperature probabilities as a function of carbon budgets; C.B. performed the data analysis and produced the plots with input by E.B. and L.D.; C.B. wrote the first draft and all authors contributed to writing the paper.</p> <h3><strong>Acknowledgments</strong></h3> <p>This research received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 821471 (ENGAGE) (C.B., E.B., L.D., G.L., B.v.R., L.A.R., L.B.B., H.-S.d.B., R.C., V.D., F.F., D.F., O.F., S.F., N.H., G.I., K.K., V.K., E.K., R.D.L., R.M., P.R., J.R., R.S., D.S., I.T., D.v.V., Z.V., K.R.). We thank A. Cherp for permission to use Figure 2 , the entire modelling teams for the development of the used IAMs and participants of the IAMC 2023 conference for helpful feedback. S.F. and D.S. are supported by the Environment Research and Technology Development Fund (JPMEERF20241001) of the Environmental Restoration and Conservation Agency of Japan and JST ASPIRE project grant number JPMJAP2331.</p>
FIGURE 14 in Notes on shark and ray types at the South China Sea Fisheries Research Institute (SCSFRI) in Guangzhou, China
FIGURE 14. Dorsal view of the holotype of Urolophus marmoratus SCSFRI N 0428 (female 742 mm TL).
FIGURE 9 in Notes on shark and ray types at the South China Sea Fisheries Research Institute (SCSFRI) in Guangzhou, China
FIGURE 9. Ventral head view the holotype of Scymnodon niger SCSFRI S 07561 (female 482 mm TL).
Dataset related to article "Use of high-resolution micro-ultrasound to predict extraprostatic extension of prostate cancer prior to surgery: a prospective single-institutional study "
<p>This record contains raw data related to article “Use of high-resolution micro-ultrasound to predict extraprostatic extension of prostate cancer prior to surgery: a prospective single institutional study"</p> <p><strong>Purpose: </strong> We aim to evaluate the accuracy of micro-ultrasound (microUS) in predicting extraprostatic extension (EPE) of Prostate Cancer (PCa) prior to surgery.</p> <p><strong>Methods: </strong> Patients with biopsy-proven PCa scheduled for robot-assisted radical prostatectomy (RARP) were prospectively recruited. The following MRI-derived microUS features were evaluated: capsular bulging, visible breach of the prostate capsule (visible extracapsular extension; ECE), presence of hypoechoic halo, and obliteration of the vesicle-prostatic angle. The ability of each feature to predict EPE was determined.</p> <p><strong>Results: </strong> Overall, data from 140 patients were examined. All predictors were associated with non-organ-confined disease (p < 0.001). Final pathology showed that 79 patients (56.4%) had a pT2 disease and 61 (43.3%) ≥ pT3. Rate of non-organ-confined disease increased from 44% in those individuals with only 1 predictor (OR 7.71) to 92.3% in those where 4 predictors (OR 72.00) were simultaneously observed. The multivariate logistic regression model including clinical parameters showed an area under the curve (AUC) of 82.3% as compared to an AUC of 87.6% for the model including both clinical and microUS parameters. Presence of ECE at microUS predicted EPE with a sensitivity of 72.1% and a specificity of 88%, a negative predictive value of 80.5% and positive predictive value of 83.0%, with an AUC of 80.4%.</p> <p><strong>Conclusions: </strong> MicroUS can accurately predict EPE at the final pathology report in patients scheduled for RARP.</p>
Expression analysis of microRNA by expression microarrays of breast cancer derived from the Cancer Institute Hospital of Japanese Foundation for Cancer Research.
GEO Series GSE105134. Homo sapiens. 50 samples. Type: Non-coding RNA profiling by array.
Transcriptome analysis by RNA-seq of gastric cancer derived from the Cancer Institute Hospital of Japanese Foundation for Cancer Research.
GEO Series GSE102156. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis by RNA-seq of patient or cell line derived xenograft of gastric cancer established in the Cancer Institute Hospital of Japanese Foundation for Cancer Research.
GEO Series GSE128285. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.