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2,227
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Dataset results
2,227 results for “Tissue expression”
Disrupted transcripitonal network in ΔNp63 AEC tissue model [gene expression]
GEO Series GSE33495. Homo sapiens. 10 samples. Type: Expression profiling by array.
Expression data from hepatocellular carcinoma and adjacent normal liver tissue
GEO Series GSE23680. Mus musculus. 8 samples. Type: Expression profiling by array.
Expression data of mesenchymal stromal cells derived from human bone marrow (BM-MSC) or autologous adipose tissues (ASC)
GEO Series GSE122778. Homo sapiens. 28 samples. Type: Expression profiling by array.
Profiling of differential allelic expression in horse, donkey, mule and hinny placental tissue
GEO Series GSE30243. Equus asinus; Equus asinus x Equus caballus; Equus caballus; Equus caballus x Equus asinus. 4 samples. Type: Expression profiling by high throughput sequencing.
Differential Expression of microRNAs in Oral Squamous cell carcinoma (OSCC) [Frozen tissue samples]
GEO Series GSE98463. synthetic construct; Homo sapiens. 16 samples. Type: Non-coding RNA profiling by array.
Exon level expression profiling of colorectal cancer tissue samples (validation sample series).
GEO Series GSE24550. Homo sapiens. 167 samples. Type: Expression profiling by array.
Expression data from mesenchymal stromal cells isolated from the umbilical cord tissue (UCX®) and cultivated in ATMP-compatible media
GEO Series GSE51869. Homo sapiens. 11 samples. Type: Expression profiling by array.
Global gene expression analysis of cotton (Gossypium hirsutum L.) under drought stress in leaf tissue.
GEO Series GSE29566. Gossypium hirsutum; Gossypium arboreum; Gossypium barbadense; Gossypium raimondii. 6 samples. Type: Expression profiling by array.
Expression profiling of colorectal cancer (CRC) tissue samples with microsatellite instability (MSI)
GEO Series GSE79959. Homo sapiens. 34 samples. Type: Expression profiling by array.
[E-MTAB-305] ncRNA expression, including snoRNAs, across 11 tissues using polyA-neutral amplification
GEO Series GSE25028. Homo sapiens. 11 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci
GEO Series GSE9950. Homo sapiens; Mus musculus. 36 samples. Type: Expression profiling by array.
Expression data of human neuroblastoma tissue samples
GEO Series GSE16237. Homo sapiens. 51 samples. Type: Expression profiling by array.
Expression data from mouse perigonadal white adipose tissue - various mutant conditions [gene-level analysis]
GEO Series GSE51202. Mus musculus. 9 samples. Type: Expression profiling by array.
Melampsora larici-populina gene expression in different tissues and developmental stages
GEO Series GSE21624. Melampsora laricis-populina. 21 samples. Type: Expression profiling by array.
Dataset related to article "Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."
<p>This record contains raw data related to article “Circulating and synovial Pentraxin-3 (PTX3) expression levels correlate with rheumatoid arthritis severity and tissue infiltration indepndently of comventional treatements response."</p> <p><strong>Aims: </strong>To determine the relationship between PTX3 systemic and synovial levels and the clinical features of rheumatoid arthritis (RA) in a cohort of early, treatment naïve patients and to explore the relevance of PTX3 expression in predicting response to conventional-synthetic (cs) Disease-Modifying-Anti-Rheumatic-Drugs (DMARDs) treatment.</p> <p><strong>Methods: </strong>PTX3 expression was analyzed in 119 baseline serum samples from early naïve RA patients, 95 paired samples obtained 6-months following the initiation of cs-DMARDs treatment and 43 healthy donors. RNA-sequencing analysis and immunohistochemistry for PTX3 were performed on a subpopulation of 79 and 58 synovial samples, respectively, to assess PTX3 gene and protein expression. Immunofluorescence staining was performed to characterize PTX3 expressing cells within the synovium.</p> <p><strong>Results: </strong>Circulating levels of PTX3 were significantly higher in early RA compared to healthy donors and correlated with disease activity at baseline and with the degree of structural damages at 12-months. Six-months after commencing cs-DMARDs, a high level of PTX3, proportional to the baseline value, was still detectable in the serum of patients, regardless of their response status. RNA-seq analysis confirmed that synovial transcript levels of PTX3 correlated with disease activity and the presence of mediators of inflammation, tissue remodeling and bone destruction at baseline. PTX3 expression in the synovium was strongly linked to the degree of immune cell infiltration, the presence of ectopic lymphoid structures and seropositivity for autoantibodies. Accordingly, PTX3 was found to be expressed by numerous synovial cell types such as plasma cells, fibroblasts, vascular and lymphatic endothelial cells, macrophages, and neutrophils. The percentage of PTX3-positive synovial cells, although significantly reduced at 6-months post-treatment as a result of global decreased cellularity, was similar in cs-DMARDs responders and non-responders.</p> <p><strong>Conclusion: </strong>This study demonstrates that, early in the disease and prior to treatment modification, the level of circulating PTX3 is a reliable marker of RA activity and predicts a high degree of structural damages at 12-months. In the joint, PTX3 associates with immune cell infiltration and the presence of ectopic lymphoid structures. High synovial and peripheral blood levels of PTX3 are associated with chronic inflammation characteristic of RA. Additional studies to determine the mechanistic link are required.</p>
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia
ClinicalTrials.gov study NCT04287998. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Tissue Factor Expression in Stage C Heart Failure
ClinicalTrials.gov study NCT00935740. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Cyclooxygenase-2 Expression in Tissue Samples From Patients With a Normal Cervix, Cervical Intraepithelial Neoplasia, or Early Invasive Cervical Cancer
ClinicalTrials.gov study NCT00900081. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx
ClinicalTrials.gov study NCT00899340. IPD Sharing: Not stated. Countries: 0. Publications: 0.
S9304A Study of Protein Expression in Tumor Tissue Samples From Patients With Stage II or Stage III Rectal Cancer Enrolled in Clinical Trial SWOG-9304
ClinicalTrials.gov study NCT00972751. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.