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1,989 results for “Blood pressure”
Deciphering the explanatory potential of blood pressure variables on post-operative length of stay through hierarchical clustering: A retrospective monocentric study
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Data from: Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda
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Data from: Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels
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Data from: Systolic blood pressure postural changes variability is associated with greater dementia risk
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Postural fall in systolic blood pressure is an useful warning sign in Dengue fever
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24-hour physiological monitoring: Electrocardiogram, interstitial glucose, and ambulatory blood pressure
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Blood pressure and dementia
<p>High blood pressure (BP) has been associated with an increased risk of cerebrovascular disease, stroke, and Alzheimer disease pathology. Epidemiologic studies are consistent in showing that high BP, particularly in midlife, is a risk factor for the development of dementia in late life. However, supporting randomized evidence of the inference that BP-lowering therapy can prevent dementia has been slow in coming over the last 30 years. The most recent randomized trial, the Systolic Blood Pressure Intervention Trial—Memory and Cognition in Decreased Hypertension (SPRINT-MIND), therefore, makes a pivotal contribution to the field, reemphasizing broader public health benefits of BP lowering and directing future research.</p>
The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney
<p>NHA2 is sodium/hydrogen exchanger that was associated with arterial hypertension in humans, but the role of NHA2 in kidney function and blood pressure homeostasis is currently unknown. Here we show that NHA2 localizes almost exclusively to distal convoluted tubules in the kidney. NHA2 knock-out mice displayed reduced blood pressure, normocalcemic hypocalciuria and an attenuated response to the thiazide diuretic hydrochlorothiazide. Phosphorylation of the thiazide-sensitive sodium/chloride cotransporter NCC and its upstream activating kinase Ste20/SPS1-related proline/alaninerich kinase (SPAK), as well as the abundance of with no lysine [K] kinase 4 (WNK4), were significantly reduced in kidneys of NHA2 knock-out mice. In vitro experiments recapitulated these findings and revealed increased WNK4 ubiquitylation and enhanced proteasomal WNK4 degradation upon loss of NHA2. The effect of NHA2 on WNK4 stability was Kelch-like 3 (KLHL3)-dependent. More specifically, loss of NHA2 selectively attenuated KLHL3 phosphorylation and the physiologically important PKAand PKC-mediated decrease of WNK4 degradation was blunted upon loss of NHA2. Phenotype analysis of NHA2/NCC double knock-out mice supported the notion that NHA2 affects blood pressure homeostasis by an intrarenal and NCC-dependent mechanism. In summary, our data reveal NHA2 as a critical component of the WNK4-NCC pathway and hence as a novel regulator of blood pressure homeostasis in the kidney.</p>
Khat and Blood Pressure data
<p>Database to confirm conclusion</p>
TIMING AND PATIENTS' POSITION DURING CUFF BLOOD PRESSURE MEASUREMENT AFFECT MYOCARDIAL WORK PARAMETERS MEASURED BY ECHOCARDIOGRAPHY
<p><span>BACKGROUND. Although cuff blood pressure measurement is a critical parameter to calculate myocardial work (MW) noninvasively, there is no recommendation about when and how to measure it. Accordingly, we sought to evaluate the effects of the timing during the echo study and the patient's position on the scanning bed during the cuff blood pressure measurement on MW parameter calculations.</span></p> <p><span>METHODS. 101 consecutive patients (44 women, 66±14 years) undergoing clinically indicated echocardiography were prospectively enrolled. During the echocardiographic study, we measured the cuff blood pressure four times, using a fully automatic digital blood pressure monitor applied to the right arm and left in the same position throughout the stud: BP1 before the start of the echo study, with the patient lying in the supine position; BP2, after positioning the patients on his/her left side to start the echo study; BP3, at the time of the acquisition of the three apical views (4-, 2-chamber, and the long-axis) used to measured left ventricular global longitudinal strain (GLS); and BP4, at the end of the echo study with the patient again in the supine position.</span></p> <p><span>RESULTS. Systolic blood pressure (SBP) at BP1 was 147±21 mm Hg. Between BP1 and BP2, it dropped by 17±9 mm Hg (p<0.05). SBP at BP3 was significantly lower than BP2 (130±20 mm Hg vs. 122±18 mm Hg, p<0.05), and at BP4 was significantly lower than at BP1 (-9±13 mm Hg, p<0.05). The average GLS was -16±3%. Accordingly, the global work index was 1929±441 mmHg% at BP1, dropped to 1717±421 at BP2, decreased to 1602±351 mm Hg% at BP3, and increased to 1815±386 mmHg% at BP4 (p<0.001).</span></p> <p><span>CONCLUSIONS. The timing during the echocardiography study and the patient's position on the scanning bed are critical determinants of the measured cuff SPB and the resulting values of MW parameters. </span></p>
Ultrasound-guided four-nerve combined block and spinal anesthesia in below-the-knee limb amputation in the elderly and blood pressure fluctuations
<p>Here is a set of retrospective data from 72 samples of below-the-knee amputations, including gender, age, surgery time, anesthesia maintenance time, postoperative opioid dosage, and intraoperative blood pressure, as well as the calculated systolic and diastolic blood pressure variability, and the amount of fluid infusion and blood loss during surgery.</p>
Blood pressure
<p>Dataset for noisy PPG with motion artifacts</p>
Effectiveness of community-based health education and home support program to reduce blood pressure among patients with uncontrolled hypertension in Nepal: A cluster-randomized trial
<p><b>Background: </b>Hypertension is a major global public health problem. Elevated blood pressure can cause cardiovascular and kidney diseases. We assessed the effectiveness of health education sessions and home support programs in reducing blood pressure among patients with uncontrolled hypertension in a suburban community of Nepal.</p> <p><b>Methods</b>: We conducted a community-based, open-level, parallel-group, cluster randomized controlled trial in Birendranagar municipality of Surkhet, Nepal. We randomly assigned four clusters (wards) into intervention and control arms. We provided four health education sessions, frequent home and usual care for intervention groups over six months. The participants of the control arm received only usual care from health facilities. The primary outcome of this study was the proportion of controlled systolic blood pressure (SBP). The analysis included all participants who completed follow-up at six months.</p> <p><b>Results</b>: 125 participants were assigned to either the intervention (n=63) or the control (n=62) group. Of them, 60 participants in each group completed six months follow-up. The proportion of controlled SBP was significantly higher among the intervention participants compared to the control (58.3% vs. 40%). Odds ratio of this was 2.1 with 95% CI: 1.01-4.35 (p=0.046) and that of controlled diastolic blood pressure (DBP) was 1.31 (0.63-2.72) (p=0.600). The mean change (follow-up minus baseline) in SBP was significantly higher in the intervention than in the usual care (-18.7 mmHg vs. -11.2 mmHg, p=0.041). Such mean change of DBP was also higher in the intervention (-10.95 mmHg vs. -5.53 mmHg, p=0.065). The knowledge score on hypertension improved by 2.38 (SD 2.4) in the intervention arm, which was significantly different from that of the control group, 0.13 (1.8) (p<0.001).</p> <p><b>Conclusions</b>: Multiple health education sessions complemented by frequent household visits by health volunteers can effectively improve knowledge on hypertension and reduce blood pressure among uncontrolled hypertensive patients at the community level in Nepal. </p> <p><b>Keywords:</b> Hypertension; Blood pressure; Systolic Blood Pressure; Diastolic Blood Pressure; Cardiovascular disease; Health Education; Home Support</p> <p><b>Trial Registration: </b>ClinicalTrial.gov: <span>NCT02981251</span></p>
Blood pressure changes during intravascular stimulation of the renal nerve
<p>Dataset of blood pressure (BP) recording during intravascular stimulation of the renal nerve in a swine model.</p> <p>Each file corresponds to one animal</p> <p>sr = sampling rate</p> <p>stimI = stimulation intensity in mA</p> <p>stimF = stimulation frequency in Hz</p> <p>stimPW = stimulation pulse width in ms</p> <p>stimzero = time from the beginning of the recording when stimulation is turned on in seconds</p> <p>stimdur = duration of the stimulation in seconds</p> <p>rawdata = original unfiltered blood pressure values</p> <p>mmvals = maximums (systolic value) and minimums (diastolic value) for each heart beat - first row is systolic values, second row is diastolic values - values are in mmHg</p> <p>mmpos = time of the recording for each systolic value and diastolic value for each heart beat - first row is systolic values, second row is diastolic values - values are in seconds</p> <p>sysP = BP systolic values after filtering to remove the influence of breathing cycles (mmHg)</p> <p>sys_t = time of each systolic value from the beginning of the recording (seconds)</p> <p>diaP = BP diastolic values after filtering to remove the influence of breathing cycles (mmHg)</p> <p>dia_t = time of each diastolic value from the beginning of the recording (seconds)</p> <p>difP = Pulse pressure (difference between systolic and diastolic) values after filtering to remove the influence of breathing cycles (mmHg)</p> <p>dif_t = time of each pulse pressure value from the beginning of the recording (seconds)</p> <p>HR = Instantaneous heart rate (beat per minute)</p> <p>HR_t = time for each of the HR value (seconds)</p> <p>sysPbn, diaPbn, difPbn, HRbn = baseline normalized data (data of previous variable after subtraction of average baseline value</p> <p>MAP = mean arterial pressure (mmHg)</p> <p>MAP_t = time for each mean arterial pressure value (sec)</p> <p>MAPbn = baseline normalized MAP data</p>
Supplemental Data for Blood Pressure Heritability Study by Lee et al.
<ul> <li> <p><strong>Data S1</strong>: Lists of top 5,000, 6,000, 7,000, 8,000, 9,000, and 10,000 expressed genes for the four BP relevant tissues and their coordinates (hg19).</p> </li> <li> <p><strong>Data S2</strong>: MACS2 peak files in the narrowPeak format for all tissues. The coordinates are in GRCh38.</p> </li> <li> <p><strong>Data S3</strong>: S-LDSC result files for analyses.</p> </li> <li> <p><strong>Data S4</strong>: gkmQC results for all chromatin accessibility peak sets, including both BP relevant and BP irrelevant tissues.</p> </li> <li> <p><strong>Data S5</strong>: Training regions (positive and negative sets) of gkm-SVM, final trained models, deltaSVM positive variants, and motif enrichment analysis results for the BP relevant tissues.</p> </li> <li> <p><strong>Data S6:</strong> The list of genes predicted to exert BP relevant function in a specific tissue.</p> </li> </ul>
Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension
ClinicalTrials.gov study NCT06098300. IPD Sharing: Not stated. Countries: 1. Publications: 31.
Early Blood Pressure Management in Extremely Premature Infants
ClinicalTrials.gov study NCT00874393. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness
ClinicalTrials.gov study NCT02940548. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Mindfulness-Based Blood Pressure Reduction: Stage 2a RCT
ClinicalTrials.gov study NCT03256890. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Validation of a Novel Non-invasive Continuous Blood Pressure Monitor in Children Ages 2- 17 Years-old
ClinicalTrials.gov study NCT04817137. IPD Sharing: NO. Countries: 1. Publications: 7.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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