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646
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ShareScore release 0.9.0
Dataset results
646 results for “Clinical data”
Data for "Clinical and virological impact of single and dual infections with influenza A (H1N1) and SARS-CoV-2 in adult inpatients"
<p>The baseline enrolled 505 patients admitted to Guangzhou Eighth People's Hospital (Guangzhou, Guangdong) with a diagnosis of COVID-19 or H1N1. All the patients were tested by both viruses at admission. Demographic, clinical, treatment, and laboratory data were extracted from electronic medical records and compared among adults (≥18 years) hospitalized for H1N1 infection (<em>n</em> = 220), SARS-CoV-2 infection (<em>n</em> = 249) and co-infection with both viruses (<em>n</em> = 36). The prevalence rate of H1N1 co-infection was 12.6% (36/285) among patients hospitalized with COVID-19. Co-infection affected a predominantly older age group and was associated with poorer clinical outcome. We also described the viral load trajectory in patients with diverse types of infection. Lower initial Ct values (higher viral loads in nasopharyngeal swabs) of co-infected patients was found to be associated with a higher number of adverse events and clinical symptoms. Considering the COVID-19 pandemic and a simultaneous epidemic of seasonal influenza, the data in China may critically inform future therapeutic or prophylactic strategies, especially for other developing countries.</p>
Data Collection; Clinical diagnosis of THI
<p>Spreadsheet outlining the extraction of data from 16 studies, & Risk of Bias Assessment.</p>
Table S1. Clinical failure rates in drug development: data sources.
<p>Supplementary table comprising the data sources used in the manuscript “No Improvement in 60 Years: Drug Failure Rates from the 1960s to the 2010s”.</p>
Data for: Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs
<p><span>Hundreds of genetic variants implicated in Mendelian disease have been characterized in dogs and commercial screening is being offered for most of them worldwide. There is typically limited information available regarding the broader population frequency of variants and uncertainty regarding their functional and clinical impact in ancestry backgrounds beyond the discovery breed. Genetic panel screening of disease variants, commercially offered directly to the consumer or via a veterinary clinician, provides an opportunity to establish large-scale cohorts with phenotype data available to address open questions related to variant prevalence and relevance. We screened the largest canine cohort examined in a single study to date (1,054,293 representative dogs from our existing cohort of 3.5 million; a total of 811,628 mixed breed dogs and 242,665 purebreds from more than 150 countries) to examine the prevalence and distribution of a total of 250 genetic disease-associated variants in the general population. Electronic medical records from veterinary clinics were available for 43.5% of the genotyped dogs, enabling the clinical impact of variants to be investigated. We provide detailed frequencies for all tested variants across breeds and find that 57% of dogs carry at least one copy of a studied Mendelian disease-associated variant. Focusing on a subset of variants, we provide evidence of full penetrance for 10 variants, and at minimum plausible evidence for clinical significance of 22 variants, on diverse breed backgrounds. Specifically, we report that inherited hypocatalasia is a notable oral health condition, confirm that factor VII deficiency presents as subclinical bleeding propensity and verify two genetic causes of reduced leg length. We further assess genome-wide heterozygosity levels in over 100 breeds and show that a reduction in genome-wide heterozygosity is associated with an increased Mendelian disease load. The accumulated knowledge represents a resource to guide discussions on genetic test relevance by breed.</span></p>
Data for: Host-specific plasmid evolution explains the variable spread of clinical antibiotic-resistance plasmids
<p><span>Antibiotic resistance encoded on plasmids is a pressing global health problem. Predicting which plasmids spread in the long term remains very challenging, even though some key parameters influencing plasmid stability have been identified, such as plasmid growth costs and horizontal transfer rates. Here, we show these parameters evolve in a strain-specific way among clinical plasmids and bacteria, and this occurs rapidly enough to alter the relative likelihoods of different bacterium-plasmid combinations spreading. We used experiments with <em>Escherichia</em> <em>coli</em> and antibiotic-resistance plasmids isolated from patients, paired with a mathematical model, to track long-term plasmid stability (beyond antibiotic exposure). Explaining variable stability across six bacterium-plasmid combinations required accounting for evolutionary changes in plasmid-stability traits, whereas initial variation of these parameters </span><span>was a relatively poor predictor of long-term outcomes</span><span>. Evolutionary trajectories were specific to particular bacterium-plasmid combinations, as evidenced by genome sequencing and genetic manipulation. This revealed epistatic (here, strain-dependent) effects of key genetic changes affecting horizontal plasmid transfer. Several genetic changes involved mobile elements and pathogenicity islands. Rapid strain-specific evolution can thus outweigh ancestral phenotypes as a predictor of plasmid stability. Accounting for strain-specific plasmid evolution in natural populations could improve our ability to anticipate and manage successful bacterium-plasmid combinations.</span></p>
Clinical Indicators and Brain Image Data: a Study Based on Kailuan Cohort
ClinicalTrials.gov study NCT05453877. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Long-Term Data Collection From Participants in Adult AIDS Clinical Trials
ClinicalTrials.gov study NCT00001137. IPD Sharing: Not stated. Countries: 2. Publications: 13.
Simulated and Synthetic Health Data: Improving Clinical Research on Rare Diseases. A Real-World Data Simulation of Autosomal Dominant Polycystic Kidney Disease (ADPKD) Trials. A Retrospective, Observa
ClinicalTrials.gov study NCT07016282. IPD Sharing: NO. Countries: 2. Publications: 27.
Machine Learning Sepsis Alert Notification Using Clinical Data
ClinicalTrials.gov study NCT04005001. IPD Sharing: NO. Countries: 1. Publications: 5.
BioTechCOACH-ForALL: Development of Mental and Physical Exercise Systems, Clinical Recording, Supervisory Analytical Large-scale Data and Virtual Guidance of Vulnerable Population Groups
ClinicalTrials.gov study NCT03877328. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Research on the Diagnostic Value of Machine Learning Model Based on Clinical Data in Patients With Coronary Heart Disease
ClinicalTrials.gov study NCT05018715. IPD Sharing: NO. Countries: 1. Publications: 1.
High-quality Image (NIR and RGB) Dataset Synchronized With Contact Vital Sings Recordings and Clinical Data of Stratified Healthy Population. Algorithms and AI Models to Obtain a Set of Vital Signs Im
ClinicalTrials.gov study NCT05947721. IPD Sharing: NO. Countries: 1. Publications: 2.
Using Big Data to Conduct Innovative Cardiovascular Clinical Trials
ClinicalTrials.gov study NCT04067297. IPD Sharing: NO. Countries: 1. Publications: 4.
Artificial Intelligence for Automated Clinical Data Exploration From Electronic Medical Records (CardioMining-AI)
ClinicalTrials.gov study NCT05176769. IPD Sharing: YES. Countries: 1. Publications: 7.
The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes
ClinicalTrials.gov study NCT03383354. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Strategic Use of Big Data in Spine Surgery - Testing Digital Prediction of Outcome in Clinical Praxis
ClinicalTrials.gov study NCT05817747. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study for the Collection of Clinical Data for Stroke Patients and Healthy Subjects
ClinicalTrials.gov study NCT05908994. IPD Sharing: YES. Countries: 1. Publications: 1.
Database for Clinical and Anamnestic Data in Pulmonary Hypertension
ClinicalTrials.gov study NCT01607502. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Personalized Medicine Program on Myelodysplastic Syndromes: Characterization of the Patient's Genome for Clinical Decision Making and Systematic Collection of Real World Data to Improve Quality of Hea
ClinicalTrials.gov study NCT04212390. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Linking Novel Diagnostics With Data-Driven Clinical Decision Support in the Emergency Department
ClinicalTrials.gov study NCT05335135. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.