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147
datasets available to search
ShareScore release 0.9.0
Dataset results
147 results for “Disease mapping”
Fine Mapping and Functional Characterization of Genetic Variants in the FAM13A Chronic Obstructive Pulmonary Disease GWAS locus using Massively Parallel Reporter Assays
GEO Series GSE109452. Homo sapiens. 4 samples. Type: Other.
Mapping cardiac remodeling in chronic Heart disease
GEO Series GSE180852. Mus musculus; Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Managed Access Program (MAP) for Patients Diagnosed With Secondary Progressive Multiple Sclerosis With Active Disease
ClinicalTrials.gov study NCT04540861. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies
GEO Series GSE213899. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Right and left ventricle native T1 mapping in systolic phase in patients with congenital heart disease
<p>Dataset from the article Secchi F, Alì M, Monti CB, Greiser A, Pluchinotta FR, Carminati M, Sardanelli F. Right and left ventricle native T1 mapping in systolic phase in patients with congenital heart disease. Acta Radiol. 2021 Mar;62(3):334-340. doi: 10.1177/0284185120924563. Epub 2020 May 31. PMID: 32475124.</p> <p><strong>Abstract</strong></p> <p><strong>Background: </strong>T1 mapping is emerging as a powerful tool in cardiac magnetic resonance (CMR) to evaluate diffuse fibrosis. However, right ventricular (RV) T1 mapping proves difficult due to the limited wall thickness in diastolic phase. Several studies focused on systolic T1 mapping, albeit only on the left ventricle (LV).</p> <p><strong>Purpose: </strong>To estimate intra- and inter-observer variability of native T1 (nT1) mapping of the RV, and its correlations with biventricular and pulmonary function in patients with congenital heart disease (CHD).</p> <p><strong>Material and methods: </strong>In this retrospective, observational, cross-sectional study we evaluated 36 patients with CHD, having undergone CMR on a 1.5-T scanner. LV and RV functional evaluations were performed. A native modified look-locker inversion recovery short-axis sequence was acquired in the systolic phase. Intra- and inter-reader reproducibility were reported as complement to 100% of the ratio between coefficient of reproducibility and mean. Spearman ρ and Mann-Whitney <em>U</em>-test were used to compare distributions.</p> <p><strong>Results: </strong>Intra- and inter-reader reproducibility was 84% and 82%, respectively. Median nT1 was 1022 ms (interquartile range [IQR] 1108-972) for the RV and 947 ms (IQR 986-914) for the LV. Median RV-nT1 was 1016 ms (IQR 1090-1016) in patients with EDVI ≤100 mL/m<sup>2</sup> and 1100 ms (IQR 1113-1100) in patients with EDVI >100 mL/m<sup>2</sup> (<em>P =</em> 0.049). A significant negative correlation was found between RV ejection fraction and RV-nT1 (ρ = -0.284, <em>P =</em> 0.046).</p> <p><strong>Conclusion: </strong>Systolic RV-nT1 showed a high reproducibility and a negative correlation with RV ejection fraction, potentially reflecting an adaptation of the RV myocardium to pulmonary valve/conduit (dys)-function.</p>
Fine mapping of a de novo interstitial 10q22-q23 duplication in a patient with congenital heart disease and microcephaly
GEO Series GSE8090. Homo sapiens. 1 samples. Type: Genome variation profiling by genome tiling array.
Fine mapping analysis of the MHC region to identify variants associated with Chinese vitiligo and SLE and association across these diseases
<p>The important role of MHC in the pathogenesis of vitiligo and SLE has been confirmed in various populations. To map the most significant MHC variants associated with the risk of vitiligo and SLE, we conducted fine mapping analysis using 1117 vitiligo cases, 1046 SLE cases and 1693 healthy control subjects in the Han-MHC reference panel and 1000 Genomes Project phase 3.</p> <p>In this study, we identified new susceptibility signals associated with risks of vitiligo and SLE and confirmed a reported allele to be associated with SLE. Furthermore, we revealed new genetic predispositions for vitiligo and SLE, advancing research into the functional mechanisms of the disease and demonstrating the correlation of vitiligo and SLE from a population genetics perspective.</p> <p> </p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.