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363
datasets available to search
ShareScore release 0.9.0
Dataset results
363 results for “EMT”
Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor
GEO Series GSE54126. Mus musculus. 6 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Novel Transcripts of EMT Driving the Malignant Transformation of Oral Submucous Fibrosis [Whole transcriptome]
GEO Series GSE274203. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic profiling of EMT in pancreatic cancer cells (ChIP-seq)
GEO Series GSE137521. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
WDR5 regulates EMT and metastasis in breast cancer by activating TGFB pathway [RNA-seq CCL]
GEO Series GSE113283. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA binding protein RBMS3 is a common effector of EMT program that promotes Triple-Negative Breast Cancer Progression by Regulation of PRRX1 mRNA Stability
GEO Series GSE181237. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
TGF-β Tumor Suppression Through A Lethal EMT
GEO Series GSE72069. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dynamics of chromatin accessibility during TGF-beta-induced EMT of Ras-transformed mammary gland epithelial cells [FAIRE-Seq]
GEO Series GSE69364. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of the tumour transition states occurring during EMT [RNA-seq]
GEO Series GSE110585. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Kinetic analysis of TGFbeta-induced EMT in NMuMG/E9 cells
GEO Series GSE112797. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
m6A-RIP-seq of mRNA in HeLa cells undergoing EMT
GEO Series GSE112795. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Time course of TGFbeta induced epithelial mesenchymal transition (EMT) in H358 NSCLC cells.
GEO Series GSE125365. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
RhoJ controls EMT associated resistance to chemotherapy
GEO Series GSE205985. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Data from: The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b
Metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. The pathophysiological course of metastasis is mediated by the dynamic plasticity of cancer cells, which enables them to shift between epithelial and mesenchymal phenotypes through a transcriptionally regulated program termed epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET). Using a mouse model of spontaneous metastatic breast cancer, we investigated the molecular mediators of metastatic competence within a heterogeneous primary tumor and how these cells then manipulated their epithelial-mesenchymal plasticity during the metastatic process. We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b. We found that this ability enabled H19 to modulate the expression of the microRNA targets Git2 and Cyth3, respectively, which encode regulators of the RAS superfamily member adenosine 5′-diphosphate (ADP) ribosylation factor (ARF), a guanosine triphosphatase (GTPase) that promotes cell migration associated with EMT and disseminating tumor cells. Decreasing the abundance of H19 or manipulating that of members in its axis prevented metastasis from grafts in syngeneic mice. Abundance of H19, GIT2, and CYTH3 in patient samples further suggests that H19 might be exploited as a biomarker for metastatic cells within breast tumors and perhaps as a therapeutic target to prevent metastasis.
The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells
<p><strong>Abstract</strong></p> <p><span>The axis CXCL12-CXCR4 is highly expressed in ovarian cancer where contributes to disease progression. Aim of the work was to evaluate the effect of the newly developed CXCR4 antagonist R54 on human ovarian cancer cells aggressiveness. CXCL12-CXCR4 axis was evaluated in human ovarian cancer cells through proliferation, migration and signaling CXCL12-dependents. Epithelial to mesenchymal transition (EMT)</span><span> </span><span>was analyzed through <em>E-CADHERIN</em>, <em>N-CADHERIN</em>, <em>VIMENTIN</em>, <em>SNAIL1</em> and <em>ΒETA-CATENIN</em> by qRT-PCR, immunofluorescence and immunoblotting.</span><span> </span><span>R54 inhibited ovarian cancer cells proliferation and migration CXCL12-induced. Moreover, R54 inhibited CXCL12 dependent pERK1/2 and pAKT and reversed the CXCL12 induced EMT in ovarian cancer cells. Targeting CXCR4 with the new antagonist R54 consistently reverted the mesenchymal transition in human ovarian cancer cells reducing migratory and chemoresistance features.</span></p>
Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.
ClinicalTrials.gov study NCT04265274. IPD Sharing: NO. Countries: 1. Publications: 0.
Influence of EMT on CTCs and Disease Progression in Prostate Cancer
ClinicalTrials.gov study NCT04021394. IPD Sharing: NO. Countries: 1. Publications: 0.
Isolation of Circulating Tumor Cells Using a Novel EMT-Based Capture Method
ClinicalTrials.gov study NCT02025413. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Delivering EMT Via Telehealth to Children and Families
ClinicalTrials.gov study NCT04604821. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of EMT on Anxiety Levels and Perception of Waiting Time in the Radiation Oncology Waiting Room
ClinicalTrials.gov study NCT03660319. IPD Sharing: NO. Countries: 1. Publications: 0.
EMT in Peritoneal Dialysis Patients
ClinicalTrials.gov study NCT03458819. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.