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2,550 results for “Glioblastoma”
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma
<p>Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with increased immune infiltration. Here, we studied the role of TSPO in the regulation of immune resistance of human GB cells. The role of TSPO in tumor immune resistance was experimentally determined in primary brain tumor initiating cells (BTICs) and cell lines through genetic manipulation of TSPO expression and subsequent cocultures with antigen specific cytotoxic T cells and autologous tumor-infiltrating T cells. Death inducing intrinsic and extrinsic apoptotic pathways affected by TSPO were investigated. TSPO-regulated genes mediating apoptosis resistance in BTICs were identified through gene expression analysis and subsequent functional analyses. TSPO transcription in primary GB cells correlated with CD8<sup>+</sup> T cell infiltration, cytotoxic activity of T cell infiltrate, expression of TNFR and IFNGR and with the activity of their downstream signalling pathways, as well as with the expression of TRAIL receptors. Coculture of BTICs with tumor reactive cytotoxic T cells or with T cell-derived factors induced TSPO up-regulation through T cell derived TNFα and IFNγ. Silencing of TSPO sensitized BTICs against T cell-mediated cytotoxicity. TSPO selectively protected BTICs against TRAIL-induced apoptosis by regulating apoptosis pathways. TSPO also regulated the expression of multiple genes associated with resistance against apoptosis. We conclude that TSPO expression in GB is induced through T cell-derived cytokines TNFα and IFNγ and that TSPO expression protects GB cells against cytotoxic T cell attack through TRAIL. Our data thereby provide an indication that therapeutic targeting of TSPO may be a suitable approach to sensitize GB to immune cell-mediated cytotoxicity by circumventing tumor intrinsic TRAIL resistance.</p>
Phase I EGFR BATs in Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT03344250. IPD Sharing: NO. Countries: 1. Publications: 3.
Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma
ClinicalTrials.gov study NCT02928575. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme
ClinicalTrials.gov study NCT00002545. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Carbon Ion Radiotherapy for Primary Glioblastoma
ClinicalTrials.gov study NCT01165671. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Low-Intensity Focused Ultrasound in Combination With Immunotherapy in Newly Diagnosed Unmethylated Glioblastoma
ClinicalTrials.gov study NCT07343986. IPD Sharing: NO. Countries: 1. Publications: 1.
Boron Neutron Capture Therapy (BNCT) as Treatment of Glioblastoma
ClinicalTrials.gov study NCT00115453. IPD Sharing: Not stated. Countries: 1. Publications: 2.
The Feasibility and Efficacy of Dose Timing (Morning vs Evening) of Temozolomide in the Treatment of Glioblastoma
ClinicalTrials.gov study NCT06850766. IPD Sharing: NO. Countries: 1. Publications: 1.
MEDICO-ECONOMIC EVALUATION OF SURGERY GUIDED BY FLUORESCENCE FOR THE OPTIMIZATION OF RESECTION OF GLIOBLASTOMAS
ClinicalTrials.gov study NCT01811121. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Temozolomide, Thalidomide, and Celecoxib Following Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00047294. IPD Sharing: Not stated. Countries: 1. Publications: 1.
AZD2171 in Treating Patients With Recurrent Glioblastoma Multiforme
ClinicalTrials.gov study NCT00305656. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT02853565. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dalteparin and Radiation Therapy in Treating Patients With Newly Diagnosed Supratentorial Glioblastoma Multiforme
ClinicalTrials.gov study NCT00028678. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Protective VEGF Inhibition for Isotoxic Dose Escalation in Glioblastoma
ClinicalTrials.gov study NCT05871021. IPD Sharing: NO. Countries: 1. Publications: 1.
Immunotherapy for Patients With Brain Stem Glioma and Glioblastoma
ClinicalTrials.gov study NCT00576641. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy
ClinicalTrials.gov study NCT03548571. IPD Sharing: NO. Countries: 1. Publications: 2.
Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT01480479. IPD Sharing: Not stated. Countries: 24. Publications: 2.
PreOperative Brain Irradiation in Glioblastoma
ClinicalTrials.gov study NCT03582514. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of the Irinotecan/Bevacizumab Association for Naive Unresectable Glioblastoma
ClinicalTrials.gov study NCT01022918. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Restrictive Use of Dexamethasone in Glioblastoma
ClinicalTrials.gov study NCT04266977. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.