Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
163
datasets available to search
ShareScore release 0.9.0
Dataset results
163 results for “HDL”
Engineered FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis
GEO Series GSE117855. Mus musculus. 6 samples. Type: Expression profiling by array.
Expression data from human coronary artery endothelial cells treated with HDL components
GEO Series GSE53201. Homo sapiens. 25 samples. Type: Expression profiling by array.
HDL suppresses the type I interferon response
GEO Series GSE19340. Mus musculus. 12 samples. Type: Expression profiling by array.
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property
<p>Various studies using proteomic approaches have shown that HDL can carry many proteins other than its constitutive apolipoprotein A-I (apoA-I). Using mass spectrometry and Western blotting, we showed the presence of alpha(1)-antitrypsin (AAT) (SERPINA1, serpin peptidase inhibitor, clade A, an elastase inhibitor) in HDL, isolated either by ultracentrifugation or by selected-affinity immunosorption using an anti-apoA-I column. Furthermore, we report that HDL possesses potent antielastase activity. We further showed that only HDL but not LDL is able to bind AAT. HDL-associated AAT was able to inhibit extracellular matrix degradation, cell detachment, and apoptosis induced by elastase in human vascular smooth muscle cells (VSMCs) and in mammary artery cultured ex vivo. Degradation of fibronectin by elastase used as a marker of pericellular proteolysis was prevented by addition of HDL. Elastase present in aortic abdominal aneurysm (AAA) thrombus samples was also able to induce apoptosis of VSMCs in culture. This phenomenon was prevented by addition of HDL but not of LDL. Finally, we report that the proportion of AAT in HDL isolated from patients with an AAA is decreased relative to that from matched control subjects, suggesting a reduced capacity of HDL to inhibit elastase in these patients. In conclusion, our data provide evidence of a new potential antiatherogenic property of HDL attributable to AAT and its antielastase activity.</p>
Study data: Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function.
<p>The complete study dataset associated with our paper describing HDL composition and function in the MFAT study:</p> <p>Jack David Beazer, Anne Sillars, Sally Beck, Christina Christoffersen, Maria J. Ferraz, Monique T. Mulder, Delyth Graham, Helen Karlsson, Stefan Ljunggren, Jason Gill, Dilys J. Freeman; Favourable HDL composition in endurance athletes is not associated with changes in HDL <em>in vitro</em> antioxidant and endothelial anti-inflammatory function. <em>Biosci Rep</em> 30 October 2024; 44 (10): BSR20241165. doi: <a href="https://doi.org/10.1042/BSR20241165" target="_blank" rel="noopener">https://doi.org/10.1042/BSR20241165</a></p> <p>Access is restricted until the publication of all related papers using this data, at which point the record will be made public. </p>
Impaired HDL and Coronary Artery Disease in Anabolic Androgenic Steroid Users
ClinicalTrials.gov study NCT03450837. IPD Sharing: NO. Countries: 0. Publications: 0.
VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis
ClinicalTrials.gov study NCT00035711. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Comparison of Fenofibrate and Niacin in Patients With Hypertriglyceridemia and Low High-Density Lipoprotein (HDL)-Cholesterol
ClinicalTrials.gov study NCT01122355. IPD Sharing: Not stated. Countries: 0. Publications: 0.
HDL-C in Cardiac Syndrome X
ClinicalTrials.gov study NCT02095964. IPD Sharing: Not stated. Countries: 0. Publications: 0.
An Observational Study of Statin Treatment Induced HDL Changes
ClinicalTrials.gov study NCT01551784. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Investigation Into the RAtio of LDL-CHolestEroL to HDL-Cholesterol Improvement After Statin Treatment in Korean Patients
ClinicalTrials.gov study NCT00931320. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Niaspan™ on High-density Lipoprotein (HDL) in Healthy Male Subjects (0000-069)
ClinicalTrials.gov study NCT01071291. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Effect of Chia Seeds on HDL Cholesterol
ClinicalTrials.gov study NCT05734170. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
HDL protects against myocardial ischemia reperfusion injury via miR-34b and miR-337 expression which requires STAT3
GEO Series GSE124176. Mus musculus; synthetic construct. 18 samples. Type: Non-coding RNA profiling by array.
The HDL-Mimetic Peptide 4F Mitigates Vascular and Cortical Amyloid Pathology and Associated Neuroinflammation in a Transgenic Mouse Model of Cerebral Amyloid Angiopathy and Alzheimer’s Disease
GEO Series GSE271286. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Effect of HDL enriched with Serum Amyloid A1 (HDL+SAA1) on Gene Expression by Classical CD14+/CD16- Human Peripheral Blood Monocytes from Asthmatics
GEO Series GSE134591. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Pla2g12b and Hpn are Genes Identified by Mouse ENU Mutagenesis that affect HDL cholesterol
GEO Series GSE37902. Mus musculus. 14 samples. Type: Expression profiling by array.
Integration of Metabolomics and Transcriptomics Reveals HDL-Driven Biliary Reverse Cholesterol Transport Involved in the Antiatherogenic Effect of San-wei-tan-xiang Capsule
GEO Series GSE236672. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Physico-chemical principles of HDL-small RNA binding interactions
GEO Series GSE191337. Homo sapiens. 67 samples. Type: Expression profiling by high throughput sequencing.
Estrogen Receptor Variants, HDL, and Atherosclerosis
ClinicalTrials.gov study NCT00081705. IPD Sharing: Not stated. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.