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144 results for “Myocarditis”
Dataset related to the article "Prior myocarditis and ventricular arrhythmias: The importance of scar pattern"
<p>This record contains raw data related to the article "Prior myocarditis and ventricular arrhythmias: The importance of scar pattern".</p> <p> </p> <p><em><strong>Abstract</strong></em></p> <p><strong>Background: </strong>Multiple studies have addressed the importance of anteroseptal scar in patients with nonischemic cardiomyopathy. However, this pattern has never been fully evaluated in patients with prior myocarditis.</p> <p><strong>Objective: </strong>The purpose of this study was to evaluate whether anteroseptal scar is associated with worse outcome in patients with prior myocarditis and how it affects the efficacy of catheter ablation (CA).</p> <p><strong>Methods: </strong>This was a retrospective study of consecutive patients with prior myocarditis and arrhythmic presentation. Cardiac magnetic resonance and electroanatomic voltage mapping were used to identify the scar pattern. Patients were referred for either CA or escalated antiarrhythmic drug (AAD) therapy. The main outcome was ventricular arrhythmia (VA)-free survival according to the presence of anteroseptal scar.</p> <p><strong>Results: </strong>A total of 144 consecutive patients with prior myocarditis were included. Mean age was 42.1 ± 14.9 years, and 58% were men. Ejection fraction was normal in 73% of patients. Anteroseptal scar was present in 44% of cases. Sixty-one patients (42%) underwent CA. Overall, at 2-year follow-up, VA-free survival was 77% in the CA group. After CA, the mean number of AADs taken by each patient decreased from 1.8 to 0.9 per day (p<0.001). The presence of anteroseptal scar was found to be an independent predictor of VA relapse both in patients treated with CA (hazard ratio [HR] 3.6; 95% confidence interval [CI] 1.1-11.4; P = .03) and in the overall population (HR 2.0; 95% CI 1.2-3.5; P = .02) .</p> <p><strong>Conclusion: </strong>In patients with prior myocarditis and VA, the presence of anteroseptal scar negatively predicts outcomes irrespective of treatment strategy.</p> <p> </p>
Diagnostic Value of Global Cardiac Strain in Patients With Myocarditis
<p>Dataset from the article Secchi F, Monti CB, Alì M, Carbone FS, Cannaò PM, Sardanelli F. Diagnostic Value of Global Cardiac Strain in Patients With Myocarditis. J Comput Assist Tomogr. 2020 Jul/Aug;44(4):591-598. doi: 10.1097/RCT.0000000000001062. PMID: 32697530.</p> <p><strong>Abstract</strong></p> <p><strong>Background: </strong>Cardiac strain represents an imaging biomarker of contractile dysfunction.</p> <p><strong>Purpose: </strong>The purpose of this study was to investigate the diagnostic value of cardiac strain obtained by feature-tracking cardiac magnetic resonance (MR) in acute myocarditis.</p> <p><strong>Materials and methods: </strong>Cardiac MR examinations of 46 patients with myocarditis and preserved ejection fraction at acute phase and follow-up were analyzed along with cardiac MR of 46 healthy age- and sex-matched controls. Global circumferential strain and global radial strain were calculated for each examination, along with myocardial edema and late gadolinium enhancement, and left ventricle functional parameters, through manual contouring of the myocardium. Correlations were assessed using Spearman ρ. Wilcoxon and Mann-Whitney U test were used to assess differences between data. Receiver operating characteristics curves and reproducibility were obtained to assess the diagnostic role of strain parameters.</p> <p><strong>Results: </strong>Global circumferential strain was significantly lower in controls (median, -20.4%; interquartile range [IQR], -23.4% to -18.7%) than patients in acute phase (-18.4%; IQR, -21.0% to -16.1%; P = 0.001) or at follow-up (-19.2%; IQR, -21.5% to -16.1%; P = 0.020). Global radial strain was significantly higher in controls (82.4%; IQR, 62.8%-104.9%) than in patients during the acute phase (65.8%; IQR, 52.9%-79.5%; P = 0.001). Correlations were found between global circumferential strain and global radial strain in all groups (acute, ρ = -0.580, P < 0.001; follow-up, ρ = -0.399, P = 0.006; controls, ρ = -0.609, P < 0.001), and between global circumferential strain and late gadolinium enhancement only in myocarditis patients (acute, ρ = 0.035, P = 0.024; follow-up, ρ = 0.307, P = 0.038).</p> <p><strong>Conclusions: </strong>Cardiac strain could potentially have a role in detecting acute myocarditis in low-risk acute myocarditis patients where cardiac MR is the main diagnosing technique.</p>
Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
<p>Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348.</p> <p>Abstract</p> <p>In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.</p>
Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients
<p>Monti CB, Secchi F, Alì M, Carbone FS, Bonomo L, Capra D, Mobini N, Di Leo G, Sardanelli F. Quantitative Assessment of Late Gadolinium Enhancement and Edema at Cardiac Magnetic Resonance in Low-Risk Myocarditis Patients. Tomography. 2022 Apr 1;8(2):974-984. doi: 10.3390/tomography8020078. PMID: 35448712; PMCID: PMC9028348.</p> <p>Abstract</p> <p>In this study, we aimed to quantify LGE and edema at short-tau inversion recovery sequences on cardiac magnetic resonance (CMR) in patients with myocarditis. We retrospectively evaluated CMR examinations performed during the acute phase and at follow-up. Forty-seven patients were eligible for retrospective LGE assessment, and, among them, twenty-five patients were eligible for edema evaluation. Both groups were paired with age- and sex-matched controls. The median left ventricle LGE was 6.4% (interquartile range 5.0-9.2%) at the acute phase, 4.4% (3.3-7.2%) at follow-up, and 4.3% (3.0-5.3%) in controls, the acute phase being higher than both follow-up and controls (<em>p &lt;</em> 0.001 for both), while follow-up and controls did not differ (<em>p =</em> 0.139). An optimal threshold of 5.0% was obtained for LGE with 87% sensitivity and 48% specificity; the positive likelihood ratio (LR) was 1.67, and the negative LR was 0.27. Edema was 12.8% (9.4-18.1%) at the acute phase, 7.3% (5.5-8.8%) at follow-up, and 6.7% (5.6-8.6%) in controls, the acute phase being higher than both follow-up and controls (both <em>p &lt;</em> 0.001), while follow-up and controls did not differ (<em>p =</em> 0.900). An optimal threshold of 9.5% was obtained for edema with a sensitivity of 76% and a specificity of 88%; the positive LR was 6.33, and the negative LR was 0.27. LGE and edema thresholds are useful in cases of suspected mild myocarditis.</p>
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Allen Brain Atlas
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OpenNeuro
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