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172
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ShareScore release 0.9.0
Dataset results
172 results for “P450”
Identification of genes responding to the activity of the Arabidopsis cytochrome P450 KLUH/CYP78A5
GEO Series GSE9201. Arabidopsis thaliana. 10 samples. Type: Expression profiling by array.
Bisphosphonate related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in MM
GEO Series GSE11948. Homo sapiens. 174 samples. Type: SNP genotyping by SNP array.
Characterization of genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway
GEO Series GSE271716. Caenorhabditis elegans. 27 samples. Type: Expression profiling by high throughput sequencing.
Characterization of a Medicago truncatula P450 monooxygenase mutant
GEO Series GSE22835. Medicago sativa; Medicago truncatula; Sinorhizobium meliloti. 6 samples. Type: Expression profiling by array.
Xenobiotic response in Drosophila melanogaster: sex dependence of P450 and GST gene induction
GEO Series GSE5125. Drosophila melanogaster. 24 samples. Type: Expression profiling by array.
Mutational signatures of genome-modified Caenorhabditis elegans expressing the human cytochrome P450 (CYP1A1 and CYP1A2) pathway
GEO Series GSE272108. Caenorhabditis elegans. 18 samples. Type: Genome variation profiling by high throughput sequencing.
Revealing New Insights into the Dynamics of Human Aromatase Interacting with Cytochrome P450 Reductase in a Realistic Membrane Environment
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Polymorphisms of cytochromes P450 and glutathione S-transferases synergistically modulate risk for Parkinson's disease
<p><span><strong>Background</strong>: </span><span>Environmental substances such as p</span><span>esticides </span><span>are well-known in </span><span>link </span><span>with</span><span> PD </span><span>risk</span><span>.</span><span> E</span><span>nzymes </span><span>including </span><span>cytochromes P450 (CYPs)</span><span>,</span><span> esterases </span><span>and </span><span>glutathione S-transferases (GSTs) </span><span>are responsible for the x</span><span>enobiotic </span><span>metabolism and </span><span>may functionally compensate each other </span><span>for subtypes in the same class. W</span><span>e hypothesize that the genetic effects </span><span>of each class </span><span>modulate PD risk stronger in a synergistic way</span> <span>than individually.</span></p> <p><span><strong>Methods</strong>: </span><span>We selected 14 polymorphic loci out of 13 </span><span>enzymes in the classes of</span><span> CYP, esterase, and GST, and recruited a cohort of 1026 PD and control subjects from eastern China. The genotypes were identified using improved multiplex ligation detection reaction, and analyzed using multiple models.</span></p> <p><span><strong>Results</strong>:</span><span> A total of 13 polymorphisms remained after Hardy-Weinberg equilibrium analysis. None of the polymorphisms were independently associated with PD risk after Bonferroni correction either by logistic regression or genetic models. In contrast, interaction analyses detected increased resistance to PD risk in individuals carrying the rs12441817/CC (<em>CYP1A1</em>) and rs2070676/G (<em>CYP2E1</em>) genotypes (P = 0.002, OR = </span><span>0.393</span><span>, 95% CI = </span><span>0.216-0.715)</span><span>,</span><span> or carrying the <em>GSTM1</em>-present, <em>GSTT1</em>-null, rs156697/G (<em>GSTO2</em>) and rs1695/AA (<em>GSTP1</em>) genotypes (<em>P</em> = 0.003, OR = </span><span>0.348</span><span>, 95% CI = </span><span>0.171-0.706</span><span>), but not with genotypes of esterases.</span></p> <p><span><strong>Conclusions</strong>:</span><span> We demonstrate a presence of synergistic but not individual impact on PD susceptibility in polymorphisms of <em>CYPs</em> and <em>GSTs</em>. The results indicate that the genetic interplay leads the way to PD development for xenobiotic metabolizing enzymes.</span></p>
Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions(DDI) Among Osteoarthritis Patients
ClinicalTrials.gov study NCT01177267. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study to Determine the Potential DDIs When the Daclatasvir/Asunaprevir/BMS-791325 Three Drug Antiviral Combination Tablet (FDC) is Coadministered With a Cocktail of Cytochrome P450 (CYP) Probe Substra
ClinicalTrials.gov study NCT02045966. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Exposure to Potential Cytochrome P450 Pharmacokinetic Drug-Drug Interactions Among Osteoarthritis Patients: Incremental Risk of Multiple Prescriptions
ClinicalTrials.gov study NCT01177254. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers
ClinicalTrials.gov study NCT02182336. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human
ClinicalTrials.gov study NCT01570569. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
ClinicalTrials.gov study NCT01169792. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cytochrome P450 Pharmacokinetic DDIs Among Patients With Chronic Low Back Pain Taking Opioids
ClinicalTrials.gov study NCT01177241. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Impact of Genotyping P450 2C19 on Hospitalization Period
ClinicalTrials.gov study NCT03554239. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers
ClinicalTrials.gov study NCT02243553. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Mechanistic Investigation Of Intestinal Cytochrome p450 3A4 Following Roux-en-Y Surgery And Its Effect on Plasma Concentrations of Buspirone
ClinicalTrials.gov study NCT02483598. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: a Metabolic Inhibition of Hepatic Cytochrome P450-3A
ClinicalTrials.gov study NCT00004564. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions Among Chronic Low Back Pain Patients Taking Opioid Analgesics and Associated Economic Outcomes
ClinicalTrials.gov study NCT01177280. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.