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1,049 results for “Pseudomonas”
Data from: Larvicidal potential of Pseudomonas mosselii isolated from Aedes (Diptera: Culicidae) egg surfaces against dengue vector mosquitoes and its impact on non-target organisms
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No major cost of evolved survivorship in Drosophila melanogaster populations coevolving with Pseudomonas entomophila
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Experimental data for Pseudomonas aeruginosa from experimental evolution under different bottleneck sizes and antibiotic selection pressures
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DNA Methyltransferase regulates nitric oxide homeostasis and virulence in a chronically adapted Pseudomonas aeruginosa strain
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Data from: Automation and machine learning drive rapid optimization of isoprenol production in Pseudomonas putida
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Drosophila melanogaster hosts coevolving with Pseudomonas entomophila pathogen show sex-specific patterns of local adaptation
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Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis
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Biosensor-driven strain engineering reveals key cellular processes for maximizing isoprenol production in <em>Pseudomonas putida</em>
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Data from: Competition for iron shapes metabolic antagonism between Bacillus subtilis and Pseudomonas
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High prevalence of lipopolysaccharide mutants and R2-Pyocin susceptible variants in Pseudomonas aeruginosa populations sourced from cystic fibrosis lung infections
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Dataset - Large-scale kinetic metabolic models of Pseudomonas putida KT2440 for consistent design of metabolic engineering strategies
<p>Models developed for the manuscript “Large-scale kinetic metabolic models of<em> Pseudomonas putida</em> for consistent design of metabolic engineering strategies" by M. Tokic, V. Hatzimanikatis, and L. Miskovic.</p> <ul> <li>Thermodynamically curated and gap-filled genome-scale model of <em>P. putida</em> iJN1411, iJN1411cur. <ul> <li>CuratediJN1411GEM.mat</li> </ul> </li> <li>Three systematically reduced stoichiometric models of <em>P. putida</em>: <ul> <li>D1 model, RedModelD1SminP2.mat</li> <li>D2 model, RedModelD2SminP2.mat - used for the studies performed in the manuscript</li> <li>D3 model, RedModelD3SminP2.mat</li> </ul> </li> </ul> <p> </p>
The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection
<p>Opportunistic pathogens are associated with a number of chronic human infections, yet the evolution of virulence in these organisms during chronic infection remains poorly understood. Here, we tested the evolution of virulence in the human opportunistic pathogen Pseudomonas aeruginosa in a murine chronic wound model using a two-part serial passage and sepsis experiment, and found that virulence evolved in different directions in each line of evolution. We also assessed P. aeruginosa adaptation to a chronic wound after 42 days of evolution and found that morphological diversity in our evolved populations was limited compared to that previously described in cystic fibrosis (CF) infections. Using whole-genome sequencing, we found that genes previously implicated in P. aeruginosa pathogenesis (lasR, pilR, fleQ, rpoN and pvcA), contained mutations during the course of evolution in wounds, with selection occurring in parallel across all lines of evolution. Our findings highlight that (i) P. aeruginosa heterogeneity may be less extensive in chronic wounds than in CF lungs; (ii) genes involved in P. aeruginosa pathogenesis acquire mutations during chronic wound infection; (iii) similar genetic adaptations are employed by P. aeruginosa across multiple infection environments and (iv) current models of virulence may not adequately explain the diverging evolutionary trajectories observed in an opportunistic pathogen during chronic wound infection.</p>
Data from: Spatial structure maintains diversity of pyocin inhibition in household Pseudomonas aeruginosa
<p><span><span><span><span><span><span><span><span><span><span><span>Nearly all bacteria produce narrow-spectrum antibiotics called bacteriocins. Studies have shown that bacteriocins can mediate microbial interactions, but the mechanisms underlying patterns of inhibition are less well understood. We assembled a spatially structured collection of isolates of <i>Pseudomonas aeruginosa</i> from bathroom and kitchen sink drains in nine households. Growth inhibition of these <i>P. aeruginosa </i>by bacteriocins, known as pyocins in this species, was measured using pairwise inhibition assays. Carbon source usage of these isolates was measured and genetic distance was estimated using multilocus sequencing. We found that as the distance between sites of isolation increased, there was a significantly higher probability of inhibition, and that pyocin inhibition and susceptibility vary greatly among isolates collected from different houses. We also detected support for other mechanisms influencing diversity: inhibition outcomes were influenced by the type of drain from which isolates were collected, and while we found no indication that carbon source utilization influences inhibition, inhibition was favored at an intermediate genetic distance. Overall, these results suggest that the combined effects of dispersal limitation among sites and competitive exclusion within them maintain diversity in pyocin inhibition and susceptibility phenotypes, and that additional processes such as local adaptation and effects of phylogenetic distance could further contribute to spatial variability.</span></span></span></span></span></span></span></span></span></span></span></p>
Spatial structure affects phage efficacy in infecting dual-strain biofilms of Pseudomonas aeruginosa
Bacterial viruses, or phage, are key members of natural microbial communities. Yet much research on bacterial-phage interactions has been conducted in liquid cultures involving single bacterial strains. Here we explored how bacterial diversity affects the success of lytic phage in structured communities. We infected a susceptible Pseudomonas aeruginosa strain PAO1 with a lytic phage Pseudomonas 352 in the presence versus absence of an insensitive P. aeruginosa strain PA14, in liquid culture versus colonies on agar. We found that both in liquid and in colonies, inter-strain competition reduced resistance evolution in the susceptible strain and decreased phage population size. However, while all sensitive bacteria died in liquid, bacteria in colonies could remain sensitive yet escape phage infection, due mainly to reduced growth in colony centers. In sum, spatial structure can protect bacteria against phage infection, while the presence of competing strains reduces the evolution of resistance to phage.
Pseudomonas_E sp002843585 BIGb0278
This is one of the Wormbiome database archive files.<br>This entry includes all the genome annotation files related to Pseudomonas_E sp002843585 BIGb0278, a\(n\) Gammaproteobacteria.<br>The Wormbiome collection is an online database dedicated to centralizing all the information related to bacteria associated with C. elegans. More information on <a href="https://bitbucket.org/the-samuel-lab/wbm_scripts/src/master/DOCS/Annotations_output.md" target="_blank" rel="noopener noreferrer">the documentation page</a>.<br><br>
Three genomes of Pseudomonas syringae pv. actinidiae and their annotation files were used for comparative genomic studies
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Fig. 2 in Pseudomonas capsici sp. nov., a plant-pathogenic bacterium isolated from pepper leaf in Georgia, USA
Fig. 2. Phylogenomic relationships between Pseudomonas capsici sp. nov. strains and closely related Pseudomonas species listed in Table 1. The tree was generated with FastME 2.1.6.1 [22] from GBDP distances calculated from genome sequences on the TYGS [19]. The branch lengths are scaled in terms of GBDP distance formula d5. The numbers at nodes are genome BLAST distance phylogeny approach pseudo-bootstrap support values (>60%) from 100 replications, with an average branch support of 94.9%. The tree was rooted at the midpoint [29]. GenBank accession numbers are shown within parentheses, with T indicating type strains.
Fig. 1 in Pseudomonas capsici sp. nov., a plant-pathogenic bacterium isolated from pepper leaf in Georgia, USA
Fig. 1. Phylogenetic relationships based on partial gene sequences of 16S rRNA between Pseudomonas capsici sp. nov. strains and closely related Pseudomonas species listed in Table 1. The 16S rRNA gene sequences (1266 nucleotides) were aligned using MAFFT (version 7.294b) [10]. The alignment was used to construct a phylogenetic tree using the PHYML package with the maximum-likelihood method and with the best substitution model estimated by jmodelTest version 2.1.10 [12]. The clade including Pseudomonas viciae, Pseudomonas brassicacearum and Pseudomonas mediterranea was used for outgroup rooting. Numbers at nodes represent bootstrap values from 1000 replicates. Bar, 1 nt substitution per 100 nt. GenBank accession numbers are shown within parentheses along with the strain, with T indicating type strains.
Data from: Mridha S and Kümmerli R (2022) Enforced specialization fosters mutual cheating and not division of labour in the bacterium Pseudomonas aeruginosa
<p><span>A common way for bacteria to cooperate is via the secretion of beneficial public goods (proteases, siderophores, biosurfactants) that can be shared among individuals in a group. Bacteria often simultaneously deploy multiple public goods with complementary functions. This raises the question whether natural selection could favour division of labour where subpopulations or species specialise in the production of a single public good, whilst sharing the complementary goods at the group level. Here we use an experimental system, where we mix engineered specialists of the bacterium <em>Pseudomonas aeruginosa</em> that can each only produce one of the two siderophores, pyochelin or pyoverdine, and explore the conditions under which specialization can lead to division of labour. When growing pyochelin and pyoverdine specialists at different mixing ratios under different levels of iron limitation, we found that specialists could only successfully complement each other in environments with moderate iron limitation and grow as good as the generalist wildtype but not better. Under more stringent iron limitation, the dynamics in specialist communities was characterized by mutual cheating and with higher proportions of pyochelin producers greatly compromising group productivity. Nonetheless, specialist communities remained stable through negative frequency-dependent selection. Our work shows that specialization in a bacterial community can be spurred by cheating and does not necessarily result in beneficial division of labour. We propose that natural selection might favour fine-tuned regulatory mechanisms in generalists over division of labour because the former enables generalists to remain flexible and adequately adjust public good investments in fluctuating environments. </span></p>
Draft Genome Sequence of Pseudomonas sp. Strain MWU13-2922, Isolated from a Wild Cranberry Bog in Truro, Massachusetts
<p>Annotated genome of Pseudomonas sp. MWU13-2922</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.