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Dataset results
153 results for “Selective signature”
Using a Stem Cell-Based Signature to Guide Therapeutic Selection in Cancer
GEO Series GSE24717. Homo sapiens. 22 samples. Type: Expression profiling by array.
Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
GEO Series GSE62080. Homo sapiens. 21 samples. Type: Expression profiling by array.
Comparative genomics of domesticated peppers and its wild progenitor reveal signature of artificial selection by human
GEO Series GSE45154. Capsicum annuum; Capsicum annuum var. glabriusculum; Capsicum chinense. 38 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Molecular Signatures Underlying Selective Regional Vulnerability to Alzheimer's Disease
GEO Series GSE84422. Homo sapiens. 2004 samples. Type: Expression profiling by array.
Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan
GEO Series GSE62322. Homo sapiens. 114 samples. Type: Expression profiling by array.
Fuzzy Logic Selection as a New Reliable Tool to Identify Gene Signatures in Breast Cancer - the INNODIAG Study
GEO Series GSE53958. Homo sapiens. 151 samples. Type: Expression profiling by array.
Signatures of positive selection in germinal center B cells
GEO Series GSE98778. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Haploid genome activation exposes genes with a specific chromatin signature for pollen selection
GEO Series GSE294738. Oryza sativa Indica Group; Oryza sativa Japonica Group. 129 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Selective CDK8 inhibitor SEL120-34A alters expression of interferon-related DNA damage resistance signature genes in colorectal cancer
GEO Series GSE77987. Homo sapiens. 24 samples. Type: Expression profiling by array.
Microarray: Discovery of a glucocorticoid receptor (GR) activity signature using selective GR antagonism in ER-negative breast cancer
GEO Series GSE113571. Homo sapiens. 15 samples. Type: Expression profiling by array.
Genome-wide Characterization of Selection Signatures and Runs of Homozygosity in Ugandan Goat Breeds
<p><strong>ABSTRACT</strong></p> <p>Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in regions associated with traits under intense selection pressure. In this study, we evaluated selection signatures and genomic inbreeding coefficients, based on runs of homozygosity (ROH), in six Ugandan goat breeds: Boer (n = 13), and the indigenous breeds Karamojong (n = 15), Kigezi (n = 29), Mubende (n = 29), Small East African (n = 29) and Sebei (n = 29). After genotyping quality control, 45,294 autosomal single nucleotide polymorphisms (SNPs) remained for further analyses. A total of 394 and 6 breed-specific putative selection signatures were identified across all breeds, based on the fixation index ( -values) and hapFLK statistics respectively. These regions were enriched with genes involved in signalling pathways associated directly or indirectly with environmental adaptation, such as immune response (e.g. <em>IL10RB</em> and <em>IL23A</em>), growth and fatty acid composition (e.g. <em>FGF9</em> and <em>IGF1</em>), and thermo-tolerance (e.g. <em>MTOR</em> and <em>MAPK3</em>). The study revealed little overlap in genomic regions under selection and generally did not display the typical classic selection signatures as expected due to the complex nature of the traits. In the Boer breed, candidate genes associated with production traits, such as body size and growth (e.g. <em>GJB2</em> and <em>GJA3</em>) were also identified. Furthermore, analysis of ROH in indigenous goat breeds showed very low levels of genomic inbreeding (with the mean per breed ranging from 0.8% to 2.4%), as compared to higher inbreeding in Boer (mean = 13.8%). And, short ROH were more frequent than long ROH, except in Karamojong, providing insight in the developmental history of these goat breeds. This study provides important insights into the effects of long-term selection in Boer and indigenous Ugandan goat breeds and its genetic. Our findings are of great relevance to the implementation of breeding programs and conservation of genetic resources, as well as their sustainable use and management.</p> <p> </p> <p> </p> <p> </p>
Gene signature of regulatory T cells isolated from children with Selective IgA Deficiency and Common Variable Immunodeficiency.
GEO Series GSE261335. Homo sapiens. 37 samples. Type: Expression profiling by array.
Demographic history and signatures of selection in the northern bottlenose whale, Hyperoodon ampullatus, through genomic resequencing data
<p>This dataset contains resequencing data used in our northern bottlenose whale genomics research. In this project, we analyzed demographic history and regions under selection. Source code for genomic analyses is available at <a href="http://github.com/edegreef/NBW-resequencing">github.com/edegreef/NBW-resequencing</a>. Data uploaded here contain:</p> <ul> <li><strong>NBW_SNPS_filtered_demography_analyses.vcf.gz</strong> - Filtered SNPs for demography analyses. Filtered for quality (removed qual < 20, mq < 30, qd < 2, missingness > 0.4), non-biallelic sites, autosomes, structural variants, minimum scaffold length 100kb.</li> <li><strong>NBW_SNPS_filtered_imputed_haplotype_analyses.vcf.gz</strong> - Filtered and imputed SNPs for haplotype analyses. Filtered for quality, non-biallelic sites, autosomes, structural variants, max-missingness 0.1, minor allele count 2, minimum scaffold length 50kb.</li> </ul>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.