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168
datasets available to search
ShareScore release 0.9.0
Dataset results
168 results for “Toxicology”
Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroid and its toxicological implications
GEO Series GSE263674. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Decoding cellular stress states for toxicology using single-cell transcriptomics [scRNA-Seq]
GEO Series GSE306046. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics Provides Mechanistic Indicators of Mixture Toxicology for IMX-101 and IMX-104 Formulations in Fathead Minnows (Pimephales promelas) [DNAN]
GEO Series GSE101870. Pimephales promelas. 12 samples. Type: Expression profiling by array.
Gene Regulation of Intestinal Porcine Epithelial Cells IPEC‑J2 is Dependent on the Site of Deoxynivalenol Toxicological Action
GEO Series GSE33246. Sus scrofa. 15 samples. Type: Expression profiling by array.
Decoding cellular stress states for toxicology using single-cell transcriptomics
GEO Series GSE299113. Homo sapiens. 478 samples. Type: Expression profiling by high throughput sequencing.
Human toxicology-relevant cell lines treated with three doses of 34 chemical compounds
GEO Series GSE69851. Homo sapiens. 1402 samples. Type: Expression profiling by array.
Caenorhabditis elegans as a Genomic Model for Toxicology
GEO Series GSE12298. Caenorhabditis elegans. 36 samples. Type: Expression profiling by array.
Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research
GEO Series GSE71407. Canis lupus familiaris; Vulpes lagopus. 12 samples. Type: Expression profiling by array.
Urine Toxicology With Pharmacogenomic Interpretation Assay: UTOPIA
ClinicalTrials.gov study NCT02096172. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Phase I Study to Evaluate Basic Pharmacodynamic, Pharmacological and Toxicological Effects of the Newly Developed Crimean-Congo Hemorrhagic Fever Vaccine for Humans
ClinicalTrials.gov study NCT03020771. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The design, pharmacology, and toxicology exploring of a novel chemically modified siRNA targeting hepatic angiotensinogen with potential application for hypertension treatment
GEO Series GSE291523. Rattus norvegicus; Homo sapiens. 132 samples. Type: Expression profiling by high throughput sequencing.
Scl-Ab: Exploratory 26-Week Subcutaneous Toxicology Study in the Aged Ovariectomized Female Sprague Dawley Rat with an 18-week Recovery [vertebrae]
GEO Series GSE71306. Rattus norvegicus. 294 samples. Type: Expression profiling by array.
Integration of toxicological end points with molecular measurements in a 28-day rat repeated dose inhalation study with cigarette smoke provides mechanistic understanding of smoke impact
GEO Series GSE50254. Rattus norvegicus. 75 samples. Type: Expression profiling by array.
Decoding cellular stress states for toxicology using single-cell transcriptomics
GEO Series GSE305216. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Comparison of toxicological effects and exposure levels between triclosan and its structurally similar chemicals using in vitro tests for read-across case study
GEO Series GSE186659. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Qualifying a human Liver-Chip for predictive toxicology: Performance assesment and economic implications
GEO Series GSE194147. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Small-Molecule-Driven Direct Reprogramming of Fibroblasts into functional Sertoli-like cells as a model for male reproductive toxicology
GEO Series GSE192401. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
TOXICOLOGY TAILORED LOW DENSITY MICROARRAY FOR THE THICKLIP GREY MULLET Chelon labrosus DEVELOPMENT, PRODUCTION AND VALIDATION
GEO Series GSE35054. Chelon labrosus. 68 samples. Type: Expression profiling by array.
The design, pharmacology, and toxicology exploring of a novel chemically modified siRNA targeting hepatic angiotensinogen with potential application for hypertension treatment
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Toxicological evaluation of Vanillin Flavor in E-Liquid Aerosols on Endothelial Cell Function: Findings from the Replica Project
<p><span>Background: There are challenges that require collaboration among researchers to ensure that tobacco harm reduction strategies are evidence-based. One key challenge is evaluating the safety of flavors used in electronic cigarettes (e-cigarettes). While many flavorings are approved as food additives or deemed “generally recognized as safe” (GRAS) for ingestion, this does not guarantee their safety when inhaled. In this context, the international research group Replica replicated a study conducted by Fetterman and colleagues in 2018, investigating the effects of aerosolized vanillin - one of the most popular flavors in vaping - on vascular endothelium when vaporized by an electronic cigarette. Methods: We used Aspire Zelos 3 e-cigarette and prepared e-liquids containing propylene glycol, vegetable glycerin and vanillin. The e-liquids were vaporized under two settings - regular (1 ohm coil using wattage control mode at 14 watts) and sub-ohm (0.3 ohm coil using temperature control mode at 200 °C) – using a vaping machine, following the standardized puffing regime, ISO20768:2018. The vapor was then collected into a trapping solution to prepare aqueous extracts for the treatment of human aortic endothelial cells. We evaluated cytotoxicity, oxidative stress, nitric oxide bioavailability, and inflammation addressing some gaps reported in the original study. Results: We observed some harmful effects, mostly attributable to ethanol, used to dilute vanillin in the original work by Fetterman, but no harmful effects on cell viability, their ability to produce nitric oxide, or oxidative stress from vanillin. Furthermore, no pro-inflammatory effects of vanillin were observed in terms of ICAM-1 and IL-6 gene expression. Conclusions: Our results confirm the endothelial cell dysfunction observed in the original paper, but clarify that these effects are mainly attributable to ethanol and not to vaporized vanillin. These findings suggest that vanillin could be a safer flavoring agent for e-cigarette, without causing adverse effects on the cardiovascular system.</span></p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.