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1,198 results for “Vaccination and immunization”
Immune Memory of DTPw-HBV/Hib Vaccine Following Primary Vaccination, Immuno & Reacto of a Booster Dose Given in Infants
ClinicalTrials.gov study NCT00169442. IPD Sharing: YES. Countries: 1. Publications: 1.
Study to Assess Safety and Ability to Induce Immune Responses of HIV-1 Vaccines M3 and M4 Given Alone or in Combination in HIV-infected Adults
ClinicalTrials.gov study NCT03844386. IPD Sharing: NO. Countries: 1. Publications: 0.
Post-Partum Immunization With Live Attenuated Influenza Vaccine (LAIV) or Trivalent Influenza Vaccine (TIV) in Post-Partum Breast Feeding Women
ClinicalTrials.gov study NCT01181323. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long-term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Mth Schedule in Healthy Adults
ClinicalTrials.gov study NCT00289770. IPD Sharing: YES. Countries: 1. Publications: 3.
Safety of and Immune Response to an H1N1 Influenza Virus Vaccine in HIV Infected Children and Youth
ClinicalTrials.gov study NCT00992836. IPD Sharing: Not stated. Countries: 2. Publications: 4.
A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Healthy Adults
ClinicalTrials.gov study NCT00474487. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate
ClinicalTrials.gov study NCT02147587. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer
ClinicalTrials.gov study NCT03300843. IPD Sharing: NO. Countries: 1. Publications: 3.
Immunization of Children Between 8 Weeks and 2 Years of Age With GSK Pneumococcal Vaccine GSK1024850A
ClinicalTrials.gov study NCT01175083. IPD Sharing: YES. Countries: 1. Publications: 1.
Nasal and Systemic Immune Responses to Nasal Influenza Vaccine
ClinicalTrials.gov study NCT04110366. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract
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Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
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Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection
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"interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination"
This archive contains an "interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination" by Luis M Franco, Kristine L Bucasas, Janet M Wells, Diane Niño, Xueqing Wang, Gladys E Zapata, Nancy Arden, Alexander Renwick, Peng Yu, John M Quarles, Molly S Bray, Robert B Couch, John W Belmont, Chad A Shaw http://dx.doi.org/10.7554/eLife.00299 (doi:10.7554/eLife.00299) Installation: (1) Download the rar file, link available from the paper. (2) Unrar the file: Mac OS X: Use UnRarX - http://www.unrarx.com Linux : unrar command - http://en.wikipedia.org/wiki/Unrar (3) Open the file "vaxgenomics.htm" in your favorite browser use File>Open : Once opened in your browser, you should see a "Circos"-style circular plot of the data, and links to the tables and figures used in this application. Each table includes a link-out from GeneID to the Entrez entry for that Gene as well as additional links to the data. The link to Entrez requires access to NCBI, so will only work if you have Internet availability for this to work. All other links point to content contained within the application/archive. (4) Figures: High-resolution copies of the figures included in the paper. Fig 1: eQTL profile of flu vaccination response. Markers associated with cis gene expression identified in the discovery cohort were replicated in a vaidation cohort and -log10 p-values for both data sets are shown in the genome wide circularized graphic. Fig 2: Effect of the treatment on eQTL assocation. We observed that the pattern of association between gene expression and SNP changed over time after vaccination. Panel A of this figure shows this phenomena for a single gene NECAB2. Panel B shows the aggregate character of this phenomena across large numbers of markers. The change in R2 compared to the initial time point is depicted; this change in R squared appears to correspond to an increase the magnitude of the slope (additive association with genotype). Fig 3: Pathways and processes identified as enriched in our candidates. Both Ingenuity IPA Analysis and GO and KEGG pathway databases were used. Heavily implicated immunologic response classes are repsresented. Fig 4: Human immune response as measured by our Antibody Response scores are correlated with gene expression changes, and these patterns are recapituoated in discovery and validation (male/female) cohorts. Fig 5: Immune cellular context of the genes identifeies in our eQTL and immune response analysis. A striking number of our validated genes occuue in the antigen processing and presentatio pnthway. Fig 6: Q-Q plot depicting that the strength of association between genotype and phenotype (titer response) is stronger for markers that have a SNP association with expression and where expression is associated with titer response than would be expected for random SNPs. Fig 7: Causal and Reactive Model Analyses. Three-way association between genotype, expression and trait. Our data are more consistent with a causal relationship compared to reactive, but the results are not definitive. We explored the sample size necessary to investigate this in the supplement. Fig 8: Diagram demonstrating the experimental design of this study. Fig 9: Population structure analysis performed on our cohort using the genome wide SNP data confirms the European ancestry and ethnic homogeoneity of our ty sample Fig 10: Schematic of the eQTL analysis. The time course of gene expression change is integrated with a single model considering effects of Day, Genotype, Day-Genotype interaction and random effects for each individual to account for the longitudinal nature of the design. email: cashaw@bcm.edu with questions or comments.
Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak
<p>Immunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: a retrospective study</p>
Serial seroprevalence study: follow-up of immunity to SARS-Cov-2 infection and monitoring of effective vaccination coverage, in three Chilean cities
<p>Population-based serosurvey in Santiago, Talca, and Coquimbo–La Serena </p>
Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants
<p>Scripts and metadata used in the analysis of the manuscript, <em>Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants.</em></p>
Innate immune responses against the mRNA component of mRNA vaccine promote cellular immunity through IFN-β at the injection site
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Dataset related to article "Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases"
<p>This record contains data related to article “Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases”</p> <p>The purpose of this study was to evaluate the efficacy and safety of the Moderna-1273 mRNA vaccine for SARS-CoV-2 in patients with immune-mediated diseases under different treatments. Anti-trimeric spike protein antibodies were tested in 287 patients with rheumatic or autoimmune diseases (10% receiving mycophenolate mofetil, 15% low-dose glucocorticoids, 21% methotrexate, and 58% biologic/targeted synthetic drugs) at baseline and in 219 (76%) 4 weeks after the second Moderna-1273 mRNA vaccine dose. Family members or caretakers were enrolled as the controls. The neutralizing serum activity against SARS-CoV-2-G614, alpha, and beta variants in vitro and the cytotoxic T cell response to SARS-CoV-2 peptides were determined in a subgroup of patients and controls. Anti-SARS-CoV-2 antibody development, i.e., seroconversion, was observed in 69% of the mycophenolate-treated patients compared to 100% of both the patients taking other treatments and the controls (<em>p</em> &lt; 0.0001). A dose-dependent impairment of the humoral response was observed in the mycophenolate-treated patients. A daily dose of &gt;1 g at vaccination was a significant risk factor for non-seroconversion (ROC AUC 0.89, 95% CI 0.80-98, <em>p</em> &lt; 0.0001). Moreover, in the seroconverted patients, a daily dose of &gt;1 g of mycophenolate was associated with significantly lower anti-SARS-CoV-2 antibody titers, showing slightly reduced neutralizing serum activity but a comparable cytotoxic response compared to other immunosuppressants. In non-seroconverted patients treated with mycophenolate at a daily dose of &gt;1 g, the cytotoxic activity elicited by viral peptides was also impaired. Mycophenolate treatment affects the Moderna-1273 mRNA vaccine immunogenicity in a dose-dependent manner, independent of rheumatological disease.</p> <p>.</p>
Assessing the Immunization Information System and Electronic Health Record interface accuracy for COVID-19 vaccinations
<p><strong>Objective</strong></p> <p>Our objective is to assess the accuracy of the COVID-19 vaccination status within the Electronic Health Record for a panel of patients in a primary care practice when manual queries of the state immunization databases are required to access outside immunization records.</p> <p><strong>Results</strong></p> <p>A manual query of the local Immunization Information Systems for 4,114 adult patients with "unknown" vaccination status showed 44% of the patients were previously vaccinated. Attempts to assess the comprehensiveness of the Immunization Information Systems were hampered by incomplete documentation in the chart and poor response to patient outreach.</p> <p><strong>Conclusions </strong></p> <p>When the interface between the patient chart and the local Immunization Information System depends on a manual query for the transfer of data, the COVID-19 vaccination status for a panel of patients is often inaccurate.</p> <p>This study was reviewed by the University of Kansas Medical Center Institutional Review Board and was designated as a quality improvement project.</p>
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