Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
696
datasets available to search
ShareScore release 0.9.0
Dataset results
696 results for “adrenal”
Combined FDG-PET and 123I-Iodometomidate Imaging for Adrenal Neoplasia
ClinicalTrials.gov study NCT02010957. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
ClinicalTrials.gov study NCT04378387. IPD Sharing: NO. Countries: 1. Publications: 8.
Adherence in Chronic Adrenal Insufficiency
ClinicalTrials.gov study NCT03399383. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Evaluation of [68Ga]Ga-PentixaFor PET Imaging for the Identification of Unilateral Adrenal Secretion of ALdosterON in Patients With Primary Aldosteronism
ClinicalTrials.gov study NCT06478875. IPD Sharing: YES. Countries: 1. Publications: 18.
Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood
ClinicalTrials.gov study NCT02377583. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Prevalence and Characteristics of Adrenal Incidentaloma
ClinicalTrials.gov study NCT04682938. IPD Sharing: NO. Countries: 1. Publications: 4.
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
ClinicalTrials.gov study NCT06955286. IPD Sharing: NO. Countries: 1. Publications: 11.
Cardiovascular Risk in Patients With Non-Functional Adrenal Incidentaloma
ClinicalTrials.gov study NCT00768365. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Diagnostic Accuracy of Adrenal Imaging for Subtype Diagnosis in Primary Aldosteronism: Systematic Review and Meta-Analysis
Open the record for dataset details and reuse information.
The neuropeptide substance P regulates aldosterone secretion in human adrenals
<p>Excel file of data demonstrating in vitro that the neuropeptide Substance P regulates aldosterone secretion in the human adrenal.</p>
Adrenal gland
Drawing uploaded to scidraw.io on: 12 March 2020
Data from: The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens
Classic findings have demonstrated an important role for sex steroids as regulators of aggression, but this relationship is lacking within some environmental contexts. In mammals and birds, the adrenal androgen dehydroepiandrosterone (DHEA), a non-gonadal precursor of biologically active steroids, has been linked to aggression. Although females, like males, use aggression when competing for limited resources, the mechanisms underlying female aggression remain understudied. Here, we propose a previously undescribed endocrine mechanism regulating female aggression via direct action of the pineal hormone melatonin on adrenal androgens. We examined this in a solitary hamster species, Phodopus sungorus, in which both sexes are highly territorial across the seasons, and display increased aggression concomitant with decreased serum levels of sex steroids in short "winter-like" days. Short- but not long-day females had increased adrenal DHEA responsiveness co-occurring with morphological changes in the adrenal gland. Further, serum DHEA and total adrenal DHEA content were elevated in short days. Lastly, melatonin increased DHEA and aggression and stimulated DHEA release from cultured adrenals. Collectively, these findings demonstrate that DHEA is a key peripheral regulator of aggression and that melatonin coordinates a "seasonal switch" from gonadal to adrenal regulation of aggression by direct action on the adrenal glands.
Figure 5 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 5 Histological analysis of the adrenal gland. A. Adrenal gland of control group; B. Adrenal gland of 100 mg chrysin-treated group.
Figure 2 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 2 The expression of target genes in the ovary of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05. 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 1 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 1 The expression of target genes in the adrenal gland of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating ΔCt and relative fold gene expression. * P ≤ 0.05, ** P ≤ 0.01. CYP17A1, cytochrome P450 family 17 subfamily A member 1; P450scc, cholesterol side-chain cleavage enzyme; 3β-HSD, 3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase.
Figure 7 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 7 Histological analysis of the adrenal gland medulla. A. Adrenal medulla of control group; B. Adrenal medulla of 100 mg chrysin-treated group.
Figure 4 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 4 Effect of chrysin on adrenal gland histology. Stained section of the control adrenal cortex showing a thin capsule (C) with underlying zona glomerulosa (G) arranged in oval or curved clusters. Zona fasciculata cells (F) are arranged in parallel cords while cells of zona reticularis (R) with anastomosing cords (H & E stain).
Figure 3 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 3 The expression of estrogen receptor-α (ERα) in the uterus of female mice is expressed as A. Delta cycle threshold (ΔCt) and B. Relative fold gene expression. β-actin was used as a housekeeping gene for calculating of ΔCt and relative fold gene expression.
Figure 6 from: Alqaisi KM, Abbas MA, Alshawawreh R (2024) Chrysin's dose-dependent effects on steroidogenesis in female BALB/c mice: In vivo study of adrenal, ovarian, and uterine hormone regulation. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e114547
Figure 6 Histological analysis of adrenal cortex. A. Adrenal cortex of the control group; B. Adrenal cortex of the 100 mg chrysin-treated group.
Different plasma steroid profiles between patients with and without diabetes mellitus in non-functioning adrenal incidentalomas
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.