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1,046 results for “anti-inflammatory”
Fig. 3 in Polyacetylene glucosides from the florets of Carthamus tinctorius and their anti-inflammatory activity
Fig. 3. The inhibitory effect of compound 1 against LPS-induced NO production in RAW264.7 cells. (A) The content of NO in RAW264.7 cells in the blank control group, model group (1 μg/mL LPS), and compound 1 group [LPS (1 μg/mL) + compound 1 (3.13, 6.25, 12.5, 25, or 50 μM)]. (B) The inhibition rates of compound 1 and positive control (curcumin) against LPS-induced NO production in RAW264.7 cells. Results are presented as the mean ± SEM for three individual experiments. ##P <0.01 vs. control group; *P <0.05, **P <0.01 vs. model group.
Fig. 1 in Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii
Fig. 1. Morphology and laser microdissection of the peltate glandular trichomes (GTs) of A. forrestii. (A) An A. forrestii plant growing in its natural habitat. (B) An A. forrestii plant blooming. (C) Peltate GTs on the leaf surface. (D) Intact peltate GTs before dissection. (E) The remaining leaf tissue after dissection of a peltate GT. (F) Peltate GTs collected in the cap of a centrifuge tube. (G) Other leaf tissues (LTs) without glandular trichomes before dissection. (H) The remaining leaf tissue after dissection of the LTs. (I) LTs collected in the cap of a centrifuge tube. Panels (C-I) are micrographs.
Fig. 2 in Antifeedant, cytotoxic, and anti-inflammatory neo-clerodane diterpenoids in the peltate glandular trichomes and fresh leaves of Ajuga forrestii
Fig. 2. Chemical structures of compounds 1–14 identified in the peltate GTs and whole leaves of A. forrestii.
Fig. 4 in Alkaloids bearing rare skeletons from Forsythia suspensa with anti-inflammatory and anti-viral activities in vitro
Fig. 4. Experimental CD spectrum of 1 (in red) in MeOH and calculated ECD spectra of 1a (4bS,8S,8aR, in black) and 1b (4bR,8R,8aS, in blue) at the b3lyp/6–31 +g (d,p) level in MeOH. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 in Benzofuran ε-caprolactam glucosides, amides and phenylpropanoid derivatives with anti-inflammatory activity from Oxybaphus himalaicus
Fig. 3. Calculated and experimental ECD spectra (a) and chiral analysis chromatogram (b) of 1a and 1b.
Fig. 2. Key HMBC, 1 H– 1 H in Benzofuran ε-caprolactam glucosides, amides and phenylpropanoid derivatives with anti-inflammatory activity from Oxybaphus himalaicus
Fig. 2. Key HMBC, 1 H– 1 H COSY and NOESY correlations of compounds (1 3) and X-ray ORTEP drawing of 1.
Fig. 5 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 5. Antioxidant activity of the examined fractions isolated from Herniaria incana (HIhfr) and Herniaria polygama (HPfr) in blood plasma under the ONOO - induced oxidative stress in vitro. Protective effects of the examined Herniaria fractions were evaluated based on measurements of protein thiol groups (panel A), 3- nitrotyrosine (panel B), and the ferric reducing ability of plasma (panel C); n = 7, 8, and 9 for –SH groups, 3-nitrotyrosine, and FRAP assay, respectively.
Fig. 4 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 4. UHPLC – diode array detector (DAD) and charged aerosol detector (CAD) profiles of the Herniaria incana herb phenolic fraction.
Fig. 3 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 3. The chemical structures of isolated compounds (46, 52, 54, 55, and 56) from Herniaria incanaherb.
Fig. 2 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 2. UHPLC – diode array detector (DAD) and charged aerosol detector (CAD) profiles of the Herniaria polygama phenolic fraction.
Fig. 6 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 6. Evaluation of protective effects of fractions isolated from Herniaria incana (HIhfr) and Herniaria polygama (HPfr) on the oxidative stress-induced modification of human fibrinogen structure. The figure contains an electrophoretic pattern of fibrinogen samples separated on gradient SDS-PAGE gel (4–20%) under the reducing conditions. Exposure of fibrinogen to ONOO resulted in the formation of high molecular weight protein aggregates (HMW), mainly derived from its Aα-chain and detectable over the fibrinogen pattern. The Herniaria fractions partly reduced these oxidative modifications to fibrinogen molecule; n = 3.
Fig. 7 in Determination of phenolic profiles of Herniaria polygama and Herniaria incana fractions and their in vitro antioxidant and anti-inflammatory effects
Fig. 7. Anti-inflammatory actions of the examined fractions isolated from Herniaria incana (HIhfr) and Herniaria polygama (HPfr) in the concanavalin A-stimulated PBMCs. Effects of the examined plant fractions were evaluated based on measurements of IL-2 (panel A) and TNF-α (panel B) secretion into the cell culture medium. The samples were assayed using the ELISA kits; *p <0.05, **p <0.01, ***p <0.001; n = 4.
Fig. 2 in Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity
Fig. 2. Key COSY (blue bold), HMBC (red arrow), and NOESY (green dashed arrow) correlations of previously undescribed compounds 1–11. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 5 in Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity
Fig. 5. Stereochemical assignment of C-2 in 9 and 10 via two different empirical rules. (A) 13C NMR chemical shifts values of C-1, C-2, C-3, and C-1′ in 9 and 10 (top), and (R)- and (S)-PG (bottom) and their differences [δ(R–S)]. (B) 1H NMR chemical shift value of H-1 in 9 and 10 (left) and (R)- and (S)-OG and (R)- and (S)-EG (right).
Fig. 3 in Glycosylated constituents isolated from the trunk of Abies holophylla and their anti-inflammatory and neurotrophic activity
Fig. 3. Extracted ion chromatograms (EICs) of chiral derivatized monosaccharides purchased or obtained by hydrolysis of isolated compounds. (A) D- and L-allopyranose (m/z 447.1260). (B) D- and L-apiofuranose (m/z 417.1154). (C) L- and D-rhamnopyranose (m/z 431.1311). (D) D- and L-glucopyranose (m/z 447.1260). (E) L- and D-arabinopyranose (m/z 417.1154). All, allopyranose. Api, apiofuranose. Rha, rhamnopyranose. Glc, glucopyranose. Ara, arabinopyranose. See the Materials and methods section below for detailed derivatization procedures.
Fig. 8 in Guaiane-type sesquiterpenoids from Cinnamomum migao H. W. Li: And their anti-inflammatory activities
Fig. 8. Inhibitory effect of compounds 1, 2, 3, 4, 5, 6, 7, 8, and 10 against the expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) (A). IC50 values of compounds 3 and 7 against TNF-α (B). The data are presented as means ± SEM in each treatment, with replicates.
Cardioprotective and Anti-inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
<p>Human plasma samples from patients with acute myocardial infarction (AMI) were obtained at 14-28 days and 6 months after index event, as part of the OMEGA-REMODEL Trial [Heydari, B., et al., <em>Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial.</em> Circulation, 2016. <strong>134</strong>(5): p. 378-91]. Patients were enrolled across 3 tertiary-care centers in Boston, MA, with each of their Institutional Review Boards approving the study (Brigham and Women’s, Massachusetts General, and Beth Israel Deaconess Medical Center hospitals). All patients received standard medical therapy per discretion of their attending cardiologists. Please refer to Heydari et al. for inclusion and exclusion criteria, and study endpoints. The primary study endpoint was change in left ventricular end-systolic volume indexed to body surface area (LVESVI, mL/m2) by cardiac MRI over 6 months. Blood samples were anticoagulated with EDTA, and plasma immediately stored at -80C with minimal number of freeze-thaw cycles before proteomic analysis. An aptamer-based proteomics platform (version 3,Somalogic) was used to measure relative levels of 1,305 analytes, corresponding to 1,1272 unique human proteins.</p>
Fig. 4. X in Sesquiterpenes from Echinacea purpurea and their anti-inflammatory activities
Fig. 4. X-ray ORTEP drawing of 1, 3–4. For 3, only one of the two molecules in the unit was shown, and solvent molecule (H2O) was omitted for clarity.
Fig. 7 in Sesquiterpenes from Echinacea purpurea and their anti-inflammatory activities
Fig. 7. Effects of compound 5 on iNOS and NF-κB protein expression on LPS-induced RAW264.7 cells. (A) Total proteins were prepared and analyzed for iNOS, NFκB, p-NF-κB and β-actin by Western blot. (B) Protein expression levels quantified fold of the level in control.
Fig. 6 in Sesquiterpenes from Echinacea purpurea and their anti-inflammatory activities
Fig. 6. The effects of different concentrations (3, 10, 30, 100 μM) of compound 5 on LPS-stimulated IL-6 (A), IL-1β (B) and TNF-α (C) in RAW 264.7 cells. The values represent mean ± SD of three independent experiments and differences between mean values were assessed by Student's t-test. *P <0.05 vs LPS, **P <0.01 vs LPS.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.