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548 results for “cardiac function”
Functional MRI to Assess Brain Damage in Cardiac Arrest Patients
ClinicalTrials.gov study NCT05966389. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of Renal Sympathetic Denervation on the Cardiac and Renal Functions in Patients With Drug-resistant Hypertension Through MRI Evaluation
ClinicalTrials.gov study NCT02164435. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Pacing Mode and Diastolic Function on Cardiac Output
ClinicalTrials.gov study NCT04068233. IPD Sharing: NO. Countries: 1. Publications: 1.
The Research Aims to Study the Effectiveness of a Physical Exercise Program on Indicators of Quality of Life and Functionality: It Will be Applied at Home to People Undergoing Cardiac Surgery, in Phas
ClinicalTrials.gov study NCT07153874. IPD Sharing: NO. Countries: 1. Publications: 6.
Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
ClinicalTrials.gov study NCT05593055. IPD Sharing: Not stated. Countries: 1. Publications: 59.
Use of Cardiac MRI in Early Stages of STEMI to Predict Left Ventricular Function Recovery and ICD Implantation
ClinicalTrials.gov study NCT03743935. IPD Sharing: NO. Countries: 1. Publications: 5.
Effects of Cross-sex Hormone Treatment on Cardiac Function, Myocardial and Hepatic Fat Content
ClinicalTrials.gov study NCT06245681. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
ClinicalTrials.gov study NCT00770107. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden
ClinicalTrials.gov study NCT01443780. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Exercise Prescription in Cardiac Rehabilitation Mediated by Autonomic Function
ClinicalTrials.gov study NCT07288840. IPD Sharing: NO. Countries: 1. Publications: 13.
Effect of Simvastatin on Cardiac Function
ClinicalTrials.gov study NCT01178710. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage Patients
ClinicalTrials.gov study NCT01801800. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Sodium Thiosulfate to Preserve Cardiac Function in STEMI
ClinicalTrials.gov study NCT02899364. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Age and sex as compounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat
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Data from: Self-reported functional status predicts post-operative outcomes in non-cardiac surgery patients with pulmonary hypertension
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Dataset related to the article "Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile"
<p>This record contains raw data related to the article "Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile". </p> <p><strong>Background:</strong> Left ventricle (LV) and right ventricle (RV) are characterized by well-known physiological differences, mainly related to their different embryological origin, hemodynamic environment, function, structure, and cellular composition. Nevertheless, scarce information is available about cellular peculiarities between left and right ventricular chambers in physiological and pathological contexts. Cardiac mesenchymal stromal cells (C-MSC) are key cells affecting many functions of the heart. Differential features that distinguish LV from RV C-MSC are still underappreciated.</p> <p><strong>Aim:</strong> To analyze the physiological differential amount, function, and transcriptome of human C-MSC in LV versus (vs.) RV.</p> <p><strong>Methods:</strong> Human cardiac specimens of LV and RV from healthy donors were used for tissue analysis of C-MSC number, and for C-MSC isolation. Paired LV and RV C-MSC were compared as for surface marker expression, cell proliferation/death ratio, migration, differentiation capabilities, and transcriptome profile.</p> <p><strong>Results:</strong> Histological analysis showed a greater percentage of C-MSC in RV vs. LV tissue. Moreover, a higher C-MSC amount was obtained from RV than from LV after isolation procedures. LV and RV C-MSC are characterized by a similar proportion of surface markers. Functional studies revealed comparable cell growth curves in cells from both ventricles. Conversely, LV C-MSC displayed a higher apoptosis rate and RV C-MSC were characterized by a higher migration speed and collagen deposition. Consistently, transcriptome analysis showed that genes related to apoptosis regulation or extracellular matrix organization and integrins were over-expressed in LV and RV, respectively. Besides, we revealed additional pathways specifically associated with LV or RV C-MSC, including energy metabolism, inflammatory response, cardiac conduction, and pluripotency.</p> <p><strong>Conclusion:</strong> Taken together, these results contribute to the functional characterization of RV and LV C-MSC in physiological conditions. This information suggests a possible differential role of the stromal compartment in chamber-specific pathologic scenarios.</p>
Dataset for publication: "Potential compensatory mechanisms preserving cardiac function in myotubular myopathy"
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Data from: The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation
Computational modeling indicates that cardiac conduction may involve ephaptic coupling - intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) -mediated adhesion scaffolds trans-activating NaV1.5 (SCN5A) channels within narrow (V1.5. Smart patch clamp (SPC) indicated greater sodium current density (INa) at perinexi, relative to non-junctional sites. A novel, rationally designed peptide, βadp1, potently and selectively inhibited β1-mediated adhesion, in electric cell-substrate impedance sensing studies. βadp1 significantly widened perinexi in guinea pig ventricles, and selectively reduced perinexal INa, but not whol e cell INa, in myocyte monolayers. In optical mapping studies, βadp1 precipitated arrhythmogenic conduction slowing. In summary, β1-mediated adhesion at the perinexus facilitates action potential propagation between cardiomyocytes and may represent a novel target for anti-arrhythmic therapies.
Functional crosstalk between phosphorylation and disease-causing mutations in the cardiac sodium channel Nav1.5
<p>Source data underlying Figs 1b, 2b-c, 3b-c, 4a-d, and Supplementary Figs 3b-e, 4b-c, 5a-b</p>
The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study
<p><strong>(1)</strong> Deficiencies in B7, B6, B9, and B12 lead to energy metabolism disruption, which induces the production of reactive oxygen species, inflammation, and lipogenesis.<sup>7</sup> <strong>(2)</strong> Reduced levels of B1, B2, B3, and B6 levels are associated with increased risk of metabolic syndrome, which is considered one of the major cases of obesity.<sup>6</sup> <strong>(3)</strong> Decreased levels of B1 and B2 are correlated with increased body mass index (BMI). <strong>(4) </strong>B6 regulates the expression of peroxisome proliferator-activated receptor gamma (PPARg) target genes, which play a key role in adipocyte gene expression and adipogenesis.<sup>40</sup> <strong>(5)</strong> Decreased B1, B3 and B6 concentrations are significantly correlated with increased risk of insulin resistance, metabolic dysfunction and obesity.<sup>41</sup> <strong>(6)</strong> B vitamins have a fundamental role in the lipid and lipoprotein metabolism cascade. Therefore, quantitative or qualitative defects in B vitamins will negatively impact the metabolism of lipid derivatives.<sup>35</sup> <strong>(7)</strong> B2 plays a vital role in energy-expenditure adipocyte gene regulation at the epigenetic level.<sup>42</sup> <strong>(8) </strong>Increased body weight leads to the reduction of vitamin B6 levels by inducing systemic oxidative stress, which leads to stimulation of adipocytokines dysregulation. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.