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6,818 results for “inhibition”
Dataset Inhibition of membrane-bound BAFF by the anti-BAFF antibody belimumab
<p>This dataset is related to "Inhibition of membrane-bound BAFF by the anti-BAFF antibody belimumab" (Kowalczyk-Quintas C, Chevalley D, Willen L, Jandus C, Vigolo M, Schneider P).</p>
Choice-induced inter-trial inhibition is modulated by idiosyncratic choice-consistency
<p>Dataset from the following publication:</p> <p>Wolf, C. & Schütz, A.C. Choice-induced inter-trial inhibition is modulated by idiosyncratic choice-consistency</p> <p><br> There is a csv and txt file containing the data. An additional csv file ('*_columnDescription') gives a description of the columns.</p> <p><br> For further questions, please contact:<br> chr.wolf[at]uni-muenster.de or a.schuetz[at]uni.marburg.de</p> <p> </p>
dataset, Heating quinoa shoots results in yield loss by inhibiting fruit production and delaying maturity
<p>Full dataset and scripts used for Tovar et al. Heating quinoa shoots results in yield loss by inhibiting fruit production and delaying maturity</p>
Self-Healing Microcapsules as Concrete Aggregates for Corrosion Inhibition in Reinforced Concrete
<p>Corresponding data set for Tran-SET Project No. 17CLSU08. Abstract of the final report is stated below for reference:</p> <p>"Reinforced Concrete (RC) structures are vital to the US’s civil infrastructure for their strength and versatility. Unfortunately, RC elements deteriorate rapidly when exposed to corrosive environments. One possible solution is to extend the life of RC elements and systems using microencapsulated corrosion inhibitors to reduce the rebar corrosion rate. The capsules house an anodic corrosion inhibitor agent including calcium nitrate (CN) and triethanolamine (TEA). The integration of such microencapsulated materials will enhance the durability and extend the useful life by controlling the corrosion precursors and the corrosion process during damage evolution. Therefore, this work aims to develop and characterize the performance of microcapsules containing corrosion inhibitors (CN-C and TEA-C) in comparison to those introduced as admixtures (CN-A and TEA-A) for reinforced concrete applications. For the corrosion tests, all samples were subjected to continuous ponding, wet/dry cycles, and fog chamber exposure to simulate different environments. The results showed that TEA-C is more effective in giving a corrosion protection than TEA-A and the Control. In contrast, the corrosion protection performance of both CN-A and CN-C was alike. The corrosion kinetics was slightly reduced on inhibited rebars compared to unprotected rebars (the Control). When comparing TEA-C and CN-C, in the presence of each stimulus (pH changes for TEA-C, cracks for CN-C), TEA-C protected the rebar better than CN-C. For the admixture samples (TEA-A and CN-A) that do not need stimuli in the concrete, a stable and better corrosion protection was provided by CN-A. The outcome of this proof-of-concept study in the laboratory validates the merit of the proposed technology for corrosion control in RC structures."</p>
Topiramate inhibits adjuvant-induced chronic orofacial inflammatory allodynia in the rat
<p>The uploaded data are the raw data from the accepted article "Topiramate inhibits adjuvant-induced chronic orofacial inflammatory allodynia in the rat", published in Frontiers in Pharmacology. </p> <p> </p>
Dataset for article: Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition
<div>This version shows the correct number of n for Figure 6.</div> <div> </div>
Supplementary material for Proctor et al., "Warm temperature inhibits cytoplasmic incompatibility induced by endosymbiotic Rickettsiella in a spider host"
<p>Included are two supplemental files: SupplementaryDocument1 includes primers and cycling conditions for qPCR quanitification of the symbiont Rickettsiella. SupplementaryDocument2 includes all raw data for the experiments included in this manuscript.</p>
Table 3 in Mowing inhibits the invasion of the alien species Solidago altissima and is an effective management strategy
<p><b>Table 3.</b> Heights of <i>S. altissima</i> before mowing in September 2019.</p><table><tbody><tr><th>Site</th><th>Control</th><th>Mowing 1</th><th>Mowing 2</th><th>Mowing 3</th></tr></tbody><tbody><tr><th>Site 1</th><td>168.0 ± 3.27a</td><td>64.0 ± 3.32c</td><td>100.5 ± 9.14b</td><td>67.5 ± 3.1c</td></tr><tr><th>Site 2</th><td>192.0 ± 11.3a</td><td>79.0 ± 4.07c</td><td>111.0 ± 6.9b</td><td>73.0 ± 7.61c</td></tr><tr><th>Site 3</th><td>159.0 ± 4.99a</td><td>123.0 ± 7.12b</td><td>84.5 ± 5.89c</td><td>47.0 ± 2.71d</td></tr><tr><th>Site 4</th><td>190.0 ± 2.98a</td><td>102.0 ± 3.89b</td><td>112.5 ±8.07b</td><td>62.0 ± 5.33c</td></tr><tr><th>Site 5</th><td>217.0 ±10.23a</td><td>87.5 ± 4.9c</td><td>137.0 ± 4.96b</td><td>62.5 ± 3.1d</td></tr><tr><th>Site 6</th><td>177.5 ± 6.76a</td><td>97.5 ± 5.44c</td><td>120.5 ± 4.97b</td><td>60.0 ± 2.58d</td></tr><tr><th>Site 7</th><td>143.5 ± 12.2a</td><td>81.0 ± 2.77b</td><td>138.5 ± 3.5a</td><td>62.0 ± 4.67b</td></tr></tbody></table><p>* Mowing 1: mowed once in July; Mowing 2: mowed twice in May and September; Mowing 3: mowed three times in May, July, and September. Data are presented as means ± standard errors of 10 replicates. Means within a row followed by different letters are significantly different at p <0.05 (ANOVA with post hoc Tukey’s test). Units: cm.</p>
Table 2 in Mowing inhibits the invasion of the alien species Solidago altissima and is an effective management strategy
<p><b>Table 2.</b> Heights of <i>S. altissima</i> before mowing treatment in May 2019.</p><table><tbody><tr><th>Site</th><th>Control</th><th>Mowing 1</th><th>Mowing 2</th><th>Mowing 3</th></tr></tbody><tbody><tr><th>Site 1</th><td>101.0 ± 3.2a</td><td>101.0 ± 3.0a</td><td>81.1 ± 2.6b</td><td>64.9 ± 3.1c</td></tr><tr><th>Site 2</th><td>116.5 ± 4.7a</td><td>111.8 ± 4.7a</td><td>82.9 ± 4.1b</td><td>72.5 ± 6.6b</td></tr><tr><th>Site 4</th><td>89.1 ± 2.2a</td><td>74.8 ± 2.2b</td><td>49.5 ± 3.1d</td><td>59.8 ± 1.6c</td></tr><tr><th>Site 5</th><td>93.5 ± 2.5a</td><td>99.5 ± 2.3a</td><td>78.0 ± 2.0b</td><td>77.1 ± 2.0b</td></tr><tr><th>Site 6</th><td>125.3 ± 5.2a</td><td>117.0 ± 3.0a</td><td>86.5 ± 3.0c</td><td>105.0 ± 3.4b</td></tr><tr><th>Site 7</th><td>123.3 ± 3.3a</td><td>119.3 ± 2.9ab</td><td>111.3 ± 2.8bc</td><td>110.3 ± 3.1c</td></tr><tr><th>Site 8</th><td>96.0 ± 4.0a</td><td>94.5 ± 4.1ab</td><td>84.5 ± 3.3bc</td><td>81.0 ± 3.1c</td></tr></tbody></table><p>* Mowing 1: mowed once in July; Mowing 2: mowed twice in May and September; Mowing 3: mowed three times in May, July, and September. Data are presented as means ± standard errors of 10 replicates. Means within a row followed by different letters are significantly different at p <0.05 (ANOVA with post hoc Tukey’s test). Units: cm.</p>
Table 1 in Mowing inhibits the invasion of the alien species Solidago altissima and is an effective management strategy
<p><b>Table 1.</b> Heights of dead shoots of <i>S. altissima</i> after 1 year of treatment in April 2019.</p><table><tbody><tr><th>Site</th><th>Control</th><th>Mowing 1</th><th>Mowing 2</th><th>Mowing 3</th><th>Eco 200</th></tr></tbody><tbody><tr><th>Site 1</th><td>162.8 ± 6.62a</td><td>85.7 ± 5.52b</td><td>29.5 ± 2.74c</td><td>21.3 ± 2.09c</td><td>77.9 ± 8.94b</td></tr><tr><th>Site 2</th><td>213.2 ± 12.08a</td><td>87.1 ± 7.33c</td><td>38.4 ± 2.17d</td><td>29.0 ± 2.01d</td><td>144.8 ± 9.57b</td></tr><tr><th>Site 3</th><td>163.4 ± 7.31a</td><td>66.3 ± 4.55c</td><td>40.7 ± 2.57d</td><td>33.4 ± 2.11d</td><td>143.4 ± 7.13b</td></tr><tr><th>Site 4</th><td>191.6 ± 3.84a</td><td>160.8 ± 7.90b</td><td>59.2 ± 1.66d</td><td>81.9 ± 6.50c</td><td>166.9 ± 12.33b</td></tr><tr><th>Site 5</th><td>181.7 ± 4.76a</td><td>114.7 ± 2.90b</td><td>89.5 ± 10.23c</td><td>46.6 ± 5.12d</td><td>183.8 ± 9.00a</td></tr><tr><th>Site 6</th><td>174.8 ± 4.34a</td><td>82.9 ± 4.49c</td><td>39.7 ± 2.51d</td><td>31.6 ± 2.47d</td><td>153.3 ± 3.12b</td></tr><tr><th>Site 7</th><td>165.5 ± 4.79a</td><td>91.2 ± 6.02b</td><td>64.7 ± 3.24c</td><td>44.0 ± 3.67d</td><td>153.8 ± 7.25a</td></tr></tbody></table><p>* Mowing 1: mowed once in July; Mowing 2: mowed twice in May and September; Mowing 3: mowed three times in May, July, and September; Eco 200: 30% of shoots in the quadrats were cut near the ground, and the cut surfaces were covered with the Eco 200 block. Data are presented as means ± standard errors of 20 replicates. Means within a row followed by different letters are significantly different at p <0.05 (ANOVA with post hoc Tukey’s test). Units: cm.</p>
Table 4 in Mowing inhibits the invasion of the alien species Solidago altissima and is an effective management strategy
<p><b>Table 4.</b> Change in areas occupied by <i>S. altissima</i> in patch-type communities from March 2018 to March 2019.</p><table><tbody><tr><th>Control</th><th>Mowing 3</th><th>Eco 20%</th><th>Eco 100%</th></tr></tbody><tbody><tr><th>205.2 ± 107.3</th><td>24.7 ± 44.0</td><td>104.5 ± 85.2</td><td><i>−</i> 31.7 ± 13.0</td></tr></tbody></table><p>Mowing 3: mowed three times in May, July, and September; Eco 20%: 20% of shoots were mowed and treated with Eco 200; Eco 100%: 100% of shoots were mowed and treated with Eco 200. Data are presented as means ± standard errors of six replicates.</p>
Data from: Recurrent sublethal warming reduces embryonic survival, inhibits juvenile growth, and alters species distribution projections under climate change
The capacity to tolerate climate change often varies across ontogeny in organisms with complex life cycles. Recently developed species distribution models incorporate traits across life stages; however, these life-cycle models primarily evaluate effects of lethal change. Here, we examine impacts of recurrent sublethal warming on development and survival in ecological projections of climate change. We reared lizard embryos in the laboratory under temperature cycles that simulated contemporary conditions and warming scenarios. We also artificially warmed natural nests to mimic laboratory treatments. In both cases, recurrent sublethal warming decreased embryonic survival and hatchling sizes. Incorporating survivorship results into a mechanistic species distribution model reduced annual survival by up to 24% compared to models that did not incorporate sublethal warming. Contrary to models without sublethal effects, our model suggests that modest increases in developmental temperatures influence species ranges due to effects on survivorship.
Innate immune activation by checkpoint inhibition in patient-derived lung cancer tissues
<p><span>Although Pembrolizumab-based immunotherapy has significantly improved lung cancer patient survival, many patients show variable efficacy and resistance development. A better understanding of the drug's action is needed to improve patient outcomes. Functional heterogeneity of the tumor microenvironment (TME) is crucial to modulating drug resistance; understanding of individual patients' TME that impacts drug response is hampered by lack of appropriate models. </span></p> <p><span>Lung organotypic tissue slice cultures (OTC) with patients' native TME procured from primary and brain-metastasized (BM) non-small cell lung cancer (NSCLC) patients were treated with Pembrolizumab and/or beta-glucan (WGP, an innate immune activator). Metabolic tracing with<sup> 13</sup>C<sub>6</sub>-Glc/<sup>13</sup>C<sub>5,</sub><sup>15</sup>N<sub>2</sub>-Gln, multiplex immunofluorescence (mIF), and digital spatial profiling (DSP) were employed to interrogate metabolic and functional responses to Pembrolizumab and/or WGP.</span></p> <p><span>Primary and BM PD-1<sup>+</sup> lung cancer OTC responded to Pembrolizumab and Pembrolizumab + WGP treatments, respectively. Pembrolizumab activated innate immune metabolism and functions in primary OTC, which were accompanied by tissue damage. DSP analysis indicated an overall decrease in immunosuppressive macrophages and T cells but revealed microheterogeneity in immune responses and tissue damage. Two TMEs with altered cancer cell properties showed resistance. Pembrolizumab or WGP alone had negligible effects on BM-lung cancer OTC but Pembrolizumab + WGP blocked central metabolism with increased pro-inflammatory effector release and tissue damage.</span></p> <p><span>In depth metabolic analysis and multiplex TME imaging of lung cancer OTC demonstrated overall innate immune activation by Pembrolizumab but heterogeneous responses in the native TME of a patient with primary NSCLC. Metabolic and functional analysis also revealed synergistic action of Pembrolizumab and WGP in OTC of metastatic NSCLC.</span></p>
FAAH inhibition in migraine pain
<p>This dataset comprises the findings obtained in the study aimed at investigating the relevance of fatty-acid amide hydrolase (FAAH) inhibition in the nitroglycerin (NTG) animal model of migraine, by testing the effects of the globally active FAAH inhibitor URB597. The attention was focused on mapping neuronal c-Fos protein expression, measurement of anandamide (AEA) and palmitoylethanolamide (PEA) levels in brain areas and in trigeminal ganglia, evaluation of pain-related trigeminal behavior and quantification of molecular mediators in rats that received URB597 (2 mg/kg i.p.) either before or after NTG administration (10 mg/kg, i.p.).</p> <ol> <li>Evaluation of c-Fos expression by immunohistochemistry: cell counts of individual brain nuclei were made from every sixth section throughout their rostrocaudal extent for each rat. The nuclei evaluated were identified with the rat brain atlas Paxinos and Watson 4th edition. Trigeminal nucleus caudalis (TNC): from bregma −14.08 mm (interaural −5.08 mm) until −17 mm (interaural −8 mm); nucleus tractus solitarii (NTS): from bregma −13.24 mm (interaural −4.24 mm) until −13.68 mm (interaural −4.68 mm); locus ceruleus (LC): from bregma −9.80 mm (interaural −0.80 mm) until −10.04 mm (interaural −1.04 mm); parabrachial nucleus (PAB): from bregma −8.80 mm (interaural 0.20 mm) until −9.80 mm (interaural −0.50 mm); periaqueductal gray (PAG): from bregma −7.80 mm (interaural 1.20 mm) until −8.80 mm (interaural 0.20 mm).</li> <li>Measurement of AEA and PEA levels: medulla, cervical spinal cord and trigeminal ganglia were homogenized in cold methanol (2 ml) containing AEA-d4 and PEA-d4 as internal standards. After extraction the lipids were measured using a Xevo TQ UPLC-MS/MS system equipped with a reversed-phase BEH C18 column (2.1 × 50 mm, 1.7 μm particle size) (Waters, Milford, USA).</li> <li>Pain-related behavior in the orofacial formalin test: the face rubbing was measured counting the seconds the animal spent grooming the injected area (upper lip, lateral to the nose) with the ipsilateral forepaw or hindpaw 0–6 min (Phase I) or 12–45 min (Phase II) after formalin injection (50 µl, s.c.). The observation time was divided into 15 blocks of 3 min each.</li> </ol> <p>mRNA expression levels: calcitonin gene-related peptide (CGRP), neuronal nitric oxide synthase (nNOS), interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-alpha) mRNA were evaluated in in medulla, cervical spinal cord and trigeminal ganglia; whereas, in dura mater were evaluated IL-1β and inducible NOS (iNOS). mRNA levels were measured by rt-PCR. All samples were assayed in triplicate and gene expression levels were calculated according to 2−∆∆Ct = 2− (∆Ct gene − ∆Ct housekeeping gene) formula by using Ct (cycle threshold) values.</p>
SGLT2-Inhibition reverts urinary peptide changes associated with severe COVID-19: an in-silico proof-of-principle of proteomics-based drug repurposing
<p>Severe COVID-19 is reflected by significant changes in urine peptides. Based on this observation, a clinical test predicting COVID-19 severity, CoV50, was developed and registered as in vitro diagnostic in Germany. We have hypothesized that molecular changes displayed by CoV50, likely reflective of endothelial damage, may be reversed by specific drugs. Such an impact by a drug could indicate potential benefits in the context of COVID-19. To test this hypothesis, urinary peptide data from patients without COVID-19 prior to and after drug treatment were collected from the human urinary proteome database. The drugs chosen were selected based on availability of sufficient number of participants in the dataset (n>20) and potential value of drug therapies in the treatment of COVID-19 based on reports in the literature. In these participants without COVID-19, spironolactone did not demonstrate a significant impact on CoV50 scoring. Empagliflozin treatment resulted in a significant change in CoV50 scoring, indicative of a potential therapeutic benefit. The study serves as a proof-of-principle for a drug repurposing approach based on human urinary peptide signatures. The results support the initiation of a randomised control trial testing a potential positive effect of empagliflozin for severe COVID-19, possibly via endothelial protective mechanisms.</p>
Data of Figure 5 from "Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes"
<p>Data of Figure 5 from “Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes”</p> <p>Dataset (doi: 10.1038/s41598-020-59701-0) contains the original publication as PDF-format (10.1038_s41598-020-59701-0). Corresponding raw data obtained from LC-MS/MS analysis provided as two files in CSV format (31003A-179400_10.1038_s41598-020-59701-0_DW_4-1.csv, 31003A-179400_10.1038_s41598-020-59701-0_DW_4-2.csv). All further experiment related information provided as three meta-data-files (31003A-179400_10.1038_s41598-020-59701-0_DW _4-1_M_1.PDF, 31003A-179400_10.1038_s41598-020-59701-0_DW _4-2_M_1.PDF, 31003A-179400_10.1038_s41598-020-59701-0_DW _4_1-2_M_2.pdf) as PDF format.</p>
Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma
<p>Code and data for manuscript "Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma"</p>
Research data supporting "Detection of microRNA biomarkers via inhibition of DNA-mediated liposome fusion"
<p>Raw research data supporting Jumeaux, C. et al., Nanoscale (2018), DOI: 10.1039/C8NA00331A .</p>
Breast cancer prevention by short-term inhibition of TGFB signaling
<p>This upload contains RDS objects of preprocessed scRNAseq data from the publication "Breast cancer prevention by short-term inhibition of TGFB signaling" (Nature Communications 2022); both for new data published with the paper, as well as for data re-analyzed for the paper.</p> <p>These RDS objects are produced by code available here <a href="https://github.com/csimona/tumor-prevention-rat-scRNAseq">https://github.com/csimona/tumor-prevention-rat-scRNAseq</a>. The same GitHub repo contains plots and tables generated from data in these objects.</p>
Data from: Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice
<p>Lipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in lupus-prone NZBWF1 mice is a preclinical model that is potentially applicable for investigating lipidome-modulating interventions. LPS can be expressed as one of two chemotypes: smooth LPS (S-LPS) and rough LPS (R-LPS) which is devoid of O-antigen polysaccharide sidechain. Since these chemotypes differentially affect TLR4-mediated immune cell responses, these differences may influence GN induction. Therefore, we initially compared the effects of subchronic i.p. injection for 5 wk with 1) <em>Salmonella</em> S-LPS, 2) <em>Salmonella</em> R-LPS, or 3) saline vehicle (VEH) (Study 1) in female NZBWF1 mice. R-LPS induced robust elevations in blood urea nitrogen, proteinuria, and hematuria that were not evident in VEH- or S-LPS-treated mice. Histopathologic examination of R-LPS-treated mice one week after final injection further revealed more robust hypertrophy, hyperplasia, thickened membranes, lymphocytic accumulation containing B and T cells, and glomerular IgG deposition consistent with GN but not in VEH- or S-LPS-treated groups. R-LPS but not S-LPS induced spleen enlargement with lymphoid hyperplasia as well as modest inflammatory cell recruitment in the liver. We next employed our optimized R-LPS model to discern the impact of two lipidome-modulating interventions, omega-3 polyunsaturated fatty acid (PUFA) supplementation and soluble epoxide hydrolase (sEH) inhibition, on GN (Study 2). Specifically, the effects of consuming the omega-3 PUFA docosahexaenoic acid (DHA) (10 g/kg diet) and/or the sEH inhibitor TPPU (22.5 mg/kg diet) on R-LPS triggering were compared. Resultant blood fatty acid profiles and epoxy fatty acid concentrations reflected the anticipated DHA- and TPPU-mediated lipidome changes. The relative rank order of R-LPS-induced GN severity among groups fed experimental diets based on proteinuria, hematuria, histopathologic scoring, and glomerular IgG deposition was: VEH/CON < R-LPS/DHA ≈ R-LPS/TPPU <<< R-LPS/ TPPU+DHA ≈ R-LPS/CON. These interventions had modest to negligible effects on R-LPS-induced splenomegaly, plasma antibody responses, liver inflammation, and inflammation-associated kidney gene expression. Collectively, our results show for the first time that absence of O-antigenic polysaccharide in R-LPS is critical to accelerated GN in lupus-prone mice. Furthermore, intervention by lipidome modulation through DHA feeding or sEH inhibition suppressed R-LPS-induced GN; however, these ameliorative effects were greatly diminished upon combining the treatments.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
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