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1,108 results for “metabolome”
Metabolomics dataset relating to the pubblication: "Combining CRISPRi and metabolomics for functional annotation of compound libraries"
<p>Metabolomics dataset relating to the pubblication: "Combining CRISPRi and metabolomics for functional annotation of compound libraries"</p>
TBT exposure dataset of the manuscript "Assessment of endocrine disruptors effects on zebrafish (Danio rerio) embryos by untargeted LC-HRMS metabolomic analysis"
<p><strong>Raw LC-HRMS data of the TBT exposure of zebrafish embryos (for more details see https://doi.org/10.1016/j.scitotenv.2018.03.369)</strong></p> <p>The exposure protocol involved zebrafish embryos exposed in groups of 20 to various concentrations of chemical compounds, with five replicates per treatment. The concentrations ranged from the lowest observed effect concentrations (LOECs) to control levels. After exposure, embryos were collected, washed, frozen, and stored. Metabolites were extracted from individual embryo pools using methanol and methionine sulfone. The extraction process included vortexing, sonication, and centrifugation, followed by addition of water and chloroform. The aqueous fraction was dried and reconstituted using acetonitrile-water solution. Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) was used for analysis. Chromatographic separations were carried out on a hydrophilic interaction liquid chromatography (HILIC) column. Mass spectrometry was performed using an Orbitrap mass spectrometer with electrospray ionization in positive and negative modes. The mass spectra were acquired at high resolution, and fragmentation scans were used for metabolite identification. The overall process aimed to analyze the metabolomic profile of zebrafish embryos exposed to different chemical concentrations.</p> <p><strong>Data files</strong></p> <blockquote> <p>TBT ESI+ (tbt_pos.rar) - CDF files</p> <p>- QC (4 replicates)</p> <p>- Control (5 replicates)</p> <p>- TBT 3 nM (5 replicates)</p> <p>- TBT 10 nM (5 replicates)</p> <p>- TBT 30 nM (5 replicates)</p> <p>- TBT 100 nM (5 replicates)</p> </blockquote> <p> </p> <blockquote> <p>TBT ESI- (tbt_neg.rar) - CDF files</p> <p>- QC (6 replicates)</p> <p>- Control (5 replicates)</p> <p>- TBT 3 nM (5 replicates)</p> <p>- TBT 10 nM (5 replicates)</p> <p>- TBT 30 nM (5 replicates)</p> <p>- TBT 100 nM (5 replicates)</p> </blockquote>
SI_III_4_Spatialized metabolomic annotation combining MALDI imaging and molecular network
<p>Ces documents regroupent les données supplémentaires générés lors du développement méthdologique pour la création de réseaux moléculaires par MALDI-FT-ICR IMS. Un .ppt regroupe l'ensemble des cartographies ioniques spécifiques à chaque ion.</p>
Plant diversity and soil legacy independently affect the plant metabolome and induced responses following herbivory
<p><span>Plant and soil biodiversity can have significant effects on herbivore resistance mediated by plant metabolites. Here, we disentangled the independent effects of plant diversity and soil legacy on constitutive and herbivore-induced plant metabolomes of three plant species in two complementary microcosm experiments.</span></p> <p><span>First, we grew plants in sterile soil with three different plant diversity levels. Second, single plant species were grown on soil with different plant diversity-induced soil legacies. We infested a subset of all plants with <em>Spodoptera</em> <em>exigua</em> larvae, a generalist leaf-chewing herbivore, and assessed foliar and root metabolomes.</span><span> </span></p> <p><span>Neither plant diversity nor soil legacy had significant effects on overall foliar, root, or herbivore-induced metabolome composition. Herbivore-induced metabolomes, however, differed from those of control plants. We detected 139 significantly regulated metabolites by comparing plants grown in monocultures with conspecifics growing in plant or soil legacy mixtures. Moreover, plant-plant and plant-soil interactions regulated 141 metabolites in herbivore-induced plants.</span><span> </span></p> <p><span>Taken together, plant diversity and soil legacy independently alter the concentration and induction of plant metabolites, thus affecting the plant's defensive capability. This is a first step towards disentangling plant and soil biodiversity effects on herbivore resistance, thereby improving our understanding of the mechanisms that govern ecosystem functioning.</span></p>
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
ClinicalTrials.gov study NCT02683876. IPD Sharing: NO. Countries: 2. Publications: 1.
Metabolomic Analysis of the Impacts of Hydration Status on Exercise Performance
ClinicalTrials.gov study NCT02486224. IPD Sharing: YES. Countries: 1. Publications: 8.
Metagenomic & Metabolomic Study: Bifidobacterium Probiotic Effects on Gut Microbiota & SCFA in Preterm NICU Infants
ClinicalTrials.gov study NCT07213414. IPD Sharing: NO. Countries: 1. Publications: 1.
Study on the Correlation Between Metabolomics and Anxiety and Depression in Bronchiectasis
ClinicalTrials.gov study NCT07291167. IPD Sharing: YES. Countries: 1. Publications: 5.
Exploratory Study of Circadian Relationships Between Social Behavior, Blood Pressure and Metabolomics
ClinicalTrials.gov study NCT02249793. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metabolomic and BH3 Profiling of Esophageal Cancers: Identification of Novel Assessment Methods of Treatment Response for Precision Therapy
ClinicalTrials.gov study NCT03223662. IPD Sharing: NO. Countries: 1. Publications: 4.
Metabolomics of Insomnia-Related Hyperarousal
ClinicalTrials.gov study NCT01957111. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics, and Metabolomics
ClinicalTrials.gov study NCT03686514. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery
ClinicalTrials.gov study NCT04689945. IPD Sharing: YES. Countries: 1. Publications: 10.
Metabolome data from bovine preovulatory follicular fluid
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NMR Metabolomic response to exercise in young and older human plasma
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Chemical properties of foliar metabolomes represent a key axis of functional trait variation in forests of the tropical Andes
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Data from: The induction of the fibroblast extracellular senescence metabolome is a dynamic process
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Modulation of the Tomato Fruit Metabolome by LED Light (GCMS and LCMS datasets)
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Data for: The salivary metabolome of children and parental caregivers in a large-scale family environment study
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Metabolomics dataset for disentangling plant and environment-mediated drivers of active rhizosphere 1 bacterial community dynamics during short-term drought
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.