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1,192
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ShareScore release 0.9.0
Dataset results
1,192 results for “multi-omics”
A Multi-omics Disease Signature Trial in Adult Patients With Moderate to Severe AD
ClinicalTrials.gov study NCT05470114. IPD Sharing: NO. Countries: 1. Publications: 0.
Multi-omics Studies of Primary Aldosteronism
ClinicalTrials.gov study NCT07111351. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain
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Data from: Understanding the transition from water to land: insights from multi-omic analyses of the perivitelline fluid of apple snail eggs
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Data from: Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin—integration and visualization of multi-omics data
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Multi-omic investigations of mouse liver subjected to simulated spaceflight freezing and storage protocols
This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage protocols used during the Rodent Research-1 (RR-1) payload. Liver samples from twelve-week old female C57BL/6J mice (snap frozen vs. 25 min. slow-frozen and stored for 3 days vs. 1 year) received from the RR-1 project were processed for extraction of RNA DNA and protein. RNA-seq whole genome bisulfite sequencing and mass spectrometry proteomics were performed. These multi-omics datasets will help distinguish the effects of freezing and storage time that could confound the interpretation of the Rodent Research-1 datasets.
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle and a concurrent ground study constituted the baseline. Transcriptomic investigation revealed an immune blunting in microgravity; Lbp MyD88 and MD-2 failed to encode proteins responsible for early LPS uptake. Longer exposure results implied that there was a delayed response potentially ineffectual in preventing pathogens from opportunistically modulating the infection network. Lack of recruitment of growth factors and a debilitated apoptosome supported this potential explanation. Certain cytokines such as IL-6 and IL-8 surged in response to LPS insult in microgravity. Contrasting expressions of B2M TIMP-1 and VEGRs suggested impaired pro-survival adaptation and healing mechanisms. The susceptibility of oxidative stress and immune regulation to microgravity compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion despite a serious drawback attributed to the small sample size we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by uG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis Inc. HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41 EA 47 EA45 and EA155 that were exposed to LPS for 4 hours. Samples EA123 EA165 EA127 EA126 were exposed to LPS for 8Hrs. Samples EA33 EA 125 EA79 and EA 39 were controls in this experiment.
Multi-omics analysis identifies progenitors of CD4-CTLs [scRNA-seq in vitro]
GEO Series GSE288988. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of human tumor-unique signaling networks between antigen-presenting cells and T cells using multi-omic single cell analysis
GEO Series GSE163633. Homo sapiens. 131 samples. Type: Expression profiling by high throughput sequencing.
Multi-omic profiling unveils molecular landscapes and heterogeneous tumor microenvironment in sinonasal squamous cell carcinoma
GEO Series GSE278149. Homo sapiens. 40 samples. Type: Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Deciphering cell states and genealogies of human hematopoiesis with single-cell multi-omics [Aged 1]
GEO Series GSE219014. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer
GEO Series GSE205049. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease
GEO Series GSE259298. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Multi-omic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals microRNA markers of almost all major cell types
GEO Series GSE178826. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes
GEO Series GSE164416. Homo sapiens. 133 samples. Type: Expression profiling by high throughput sequencing.
Integrative multi-omics analysis reveals conserved cell-projection deficits in human Down syndrome brains [TotalRNAseq]
GEO Series GSE221178. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
INTEGRATIVE MULTI-OMICS REVEAL A TWO-ANALYTE BLOOD-BASED SIGNATURE FOR TB DIAGNOSIS IN ADVANCED HIV
GEO Series GSE166557. Homo sapiens. 56 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Intergrative Multi-Omics of Asian Pregnant Mother
GEO Series GSE182409. Homo sapiens. 238 samples. Type: Expression profiling by high throughput sequencing.
Multi-omics insights into the response of Aspergillus parasiticus to long-chain alkanes in relation to polyethylene modification
GEO Series GSE282836. Aspergillus parasiticus. 8 samples. Type: Expression profiling by high throughput sequencing.
Multi-omic analysis of cell-of-origin and epigenomic state in pediatric H3K27M gliomas (scRNA-Seq)
GEO Series GSE210567. Homo sapiens. 37 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.