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1,205 results for “vaccine responses”
Safety and Immune Response of a Rotavirus Vaccine in HIV-infected and Uninfected Children Born to HIV-infected Mothers
ClinicalTrials.gov study NCT00880698. IPD Sharing: Not stated. Countries: 4. Publications: 4.
A Study on the Immune Response and Safety of Various Potencies of an Investigational Chickenpox Vaccine Compared With a Marketed Chickenpox Vaccine, Given to Healthy Children 12 to 15 Months of Age
ClinicalTrials.gov study NCT05084508. IPD Sharing: YES. Countries: 6. Publications: 0.
A Study to Assess the Safety and Immune Response of Quadrivalent Seasonal Influenza Vaccine (Fluarix Tetra) in Participants Aged 65 Years and Older in India
ClinicalTrials.gov study NCT05648357. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children
ClinicalTrials.gov study NCT01246999. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Evaluation of Human Immune Responses to Influenza Virus Vaccination in Healthy Volunteers
ClinicalTrials.gov study NCT02385123. IPD Sharing: NO. Countries: 1. Publications: 4.
Study to Assess Safety and Ability to Induce Immune Responses of HIV-1 Vaccines M3 and M4 Given Alone or in Combination in HIV-infected Adults
ClinicalTrials.gov study NCT03844386. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety of and Immune Response to an H1N1 Influenza Virus Vaccine in HIV Infected Children and Youth
ClinicalTrials.gov study NCT00992836. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Study Evaluating Persistence Of Antibody Response Elicited By 13vPnC In Healthy Adults Previously Vaccinated
ClinicalTrials.gov study NCT01025336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Healthy Adults
ClinicalTrials.gov study NCT00474487. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate
ClinicalTrials.gov study NCT02147587. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease
ClinicalTrials.gov study NCT01974817. IPD Sharing: NO. Countries: 1. Publications: 1.
Nasal and Systemic Immune Responses to Nasal Influenza Vaccine
ClinicalTrials.gov study NCT04110366. IPD Sharing: YES. Countries: 1. Publications: 1.
The metabolic hormone adiponectin affects the correlation between nutritional status and pneumococcal vaccine response in vulnerable indigenous children
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Data from: Genome-wide epitope mapping reveals significant diversity in antibody responses to Coxiella burnetii vaccination and infection
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Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
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Pregnancy and lactation induce distinct immune responses to COVID-19 booster vaccination and SARS-CoV-2 breakthrough infection
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Effect of ocrelizumab on vaccine responses in patients with multiple sclerosis: The VELOCE study
<p><b>Objective</b></p> <p><span>The phase IIIb VELOCE study (NCT02545868) assessed responses to selected vaccines in ocrelizumab (OCR)-treated patients with relapsing multiple sclerosis.</span></p> <p><b>Methods</b></p> <p>Patients were randomized 2:1 into Group OCR (n=68; OCR 600mg); or Control (n=34; interferon-β or no disease-modifying therapy). All received tetanus toxoid (TT)-containing vaccine, Pneumovax® (23-PPV) and keyhole limpet hemocyanin (KLH). Group OCR was subdivided into OCR1 (n=33) and OCR2 (n=35) at randomization. OCR1 received Prevnar® (13-PCV) 4 weeks after 23-PPV; OCR2 and Control received influenza vaccine. Vaccinations started 12 weeks after OCR initiation (Group OCR) or on Day 1 (Control).</p> <p><b>Results</b></p> <p>Positive response rate to TT vaccine at 8 weeks was 23.9% in OCR vs 54.5% in Control. Positive response rate to ≥5 serotypes in 23-PPV at 4 weeks was 71.6% in OCR and 100% in Control. Prevnar® did not enhance response to pneumococcal serotypes in common with Pneumovax®. Humoral response to KLH was decreased in OCR vs Control. Seroprotection rates at 4 weeks against five influenza strains ranged from 55.6–80.0% in OCR2 and 75.0–97.0% in Control.</p> <p><b>Conclusion</b></p> <p>Peripherally B-cell depleted OCR recipients mounted attenuated humoral responses to clinically relevant vaccines and the neoantigen, KLH, suggesting use of standard non-live vaccines while on OCR treatment remains a consideration. For seasonal influenza vaccines, it is recommended to vaccinate patients on OCR, as a potentially protective humoral response, even if attenuated, can be expected.</p>
"interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination"
This archive contains an "interactive" version of data associated with the eLife paper "Integrative genomic analysis of the human immune response to influenza vaccination" by Luis M Franco, Kristine L Bucasas, Janet M Wells, Diane Niño, Xueqing Wang, Gladys E Zapata, Nancy Arden, Alexander Renwick, Peng Yu, John M Quarles, Molly S Bray, Robert B Couch, John W Belmont, Chad A Shaw http://dx.doi.org/10.7554/eLife.00299 (doi:10.7554/eLife.00299) Installation: (1) Download the rar file, link available from the paper. (2) Unrar the file: Mac OS X: Use UnRarX - http://www.unrarx.com Linux : unrar command - http://en.wikipedia.org/wiki/Unrar (3) Open the file "vaxgenomics.htm" in your favorite browser use File>Open : Once opened in your browser, you should see a "Circos"-style circular plot of the data, and links to the tables and figures used in this application. Each table includes a link-out from GeneID to the Entrez entry for that Gene as well as additional links to the data. The link to Entrez requires access to NCBI, so will only work if you have Internet availability for this to work. All other links point to content contained within the application/archive. (4) Figures: High-resolution copies of the figures included in the paper. Fig 1: eQTL profile of flu vaccination response. Markers associated with cis gene expression identified in the discovery cohort were replicated in a vaidation cohort and -log10 p-values for both data sets are shown in the genome wide circularized graphic. Fig 2: Effect of the treatment on eQTL assocation. We observed that the pattern of association between gene expression and SNP changed over time after vaccination. Panel A of this figure shows this phenomena for a single gene NECAB2. Panel B shows the aggregate character of this phenomena across large numbers of markers. The change in R2 compared to the initial time point is depicted; this change in R squared appears to correspond to an increase the magnitude of the slope (additive association with genotype). Fig 3: Pathways and processes identified as enriched in our candidates. Both Ingenuity IPA Analysis and GO and KEGG pathway databases were used. Heavily implicated immunologic response classes are repsresented. Fig 4: Human immune response as measured by our Antibody Response scores are correlated with gene expression changes, and these patterns are recapituoated in discovery and validation (male/female) cohorts. Fig 5: Immune cellular context of the genes identifeies in our eQTL and immune response analysis. A striking number of our validated genes occuue in the antigen processing and presentatio pnthway. Fig 6: Q-Q plot depicting that the strength of association between genotype and phenotype (titer response) is stronger for markers that have a SNP association with expression and where expression is associated with titer response than would be expected for random SNPs. Fig 7: Causal and Reactive Model Analyses. Three-way association between genotype, expression and trait. Our data are more consistent with a causal relationship compared to reactive, but the results are not definitive. We explored the sample size necessary to investigate this in the supplement. Fig 8: Diagram demonstrating the experimental design of this study. Fig 9: Population structure analysis performed on our cohort using the genome wide SNP data confirms the European ancestry and ethnic homogeoneity of our ty sample Fig 10: Schematic of the eQTL analysis. The time course of gene expression change is integrated with a single model considering effects of Day, Genotype, Day-Genotype interaction and random effects for each individual to account for the longitudinal nature of the design. email: cashaw@bcm.edu with questions or comments.
Quality of vaccination-induced T cell responses is conveyed by polyclonality and high, but not maximum, antigen receptor avidity
<p>This repository contains the processed data of the single-cell T cell analysis connected to the manuscript "Diverse and balanced repertoires of high-functionality T cell receptors are induced by SARS-CoV-2 mRNA vaccination" from Kocher and Drost et al. </p> <p>The data is stored in the AnnData (Scanpy+Scirpy) format and can be reproduced with this GitHub repository (<a href="https://github.com/SchubertLab/CovidVac_CD8">https://github.com/SchubertLab/CovidVac_CD8/</a>) from the raw data stored under GEO accession numbers GSE261966, GSE261967, and GSE249998. </p> <p><span><span> </span></span></p>
Innate immune responses against the mRNA component of mRNA vaccine promote cellular immunity through IFN-β at the injection site
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.