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1,884
datasets available to search
ShareScore release 0.9.0
Dataset results
1,884 results for “skeletal muscle”
Common Gene Transcriptional Patterns Following Immobilization, Spinal Cord Injury, and Unloading in Human Skeletal Muscle
GEO Series GSE21497. Homo sapiens. 20 samples. Type: Expression profiling by array.
TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle
GEO Series GSE72462. Homo sapiens. 36 samples. Type: Expression profiling by array.
Skeletal Muscle Methylome-Transcriptome Disruptions During the Onset and Progression of Colorectal Cancer-Induced Cachexia
GEO Series GSE314368. Mus musculus. 88 samples. Type: Methylation profiling by high throughput sequencing.
Cancer-induced FOXP1 disrupts and reprograms skeletal muscle circadian transcription in cachexia [circadian RNA-seq]
GEO Series GSE273878. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Leucine differentially regulates gene-specific translation in mouse skeletal muscle
GEO Series GSE99585. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Novel effects of reverse transcriptase inhibitor supplementation in skeletal muscle of old mice
GEO Series GSE284098. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Effect of age, calorie restriction and resveratrol on gene expression in mouse heart, brain, and skeletal muscle
GEO Series GSE11291. Mus musculus. 60 samples. Type: Expression profiling by array.
Distinct Protein Degradation Induced by Different Disuse Models of Skeletal Muscle Atrophy
GEO Series GSE25908. Mus musculus. 111 samples. Type: Expression profiling by array.
SMTNL1 Regulates Development and Metabolic Transformation of Skeletal Muscle in Hyperthyroidism
GEO Series GSE178996. Homo sapiens. 6 samples. Type: Expression profiling by array.
MEF2C chip in the skeletal muscle of PRR14-KO mice
GEO Series GSE271658. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from Males
GEO Series GSE222317. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing.
Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells [RNA-seq]
GEO Series GSE227076. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Changes in Protein Fluxes in Skeletal Muscle During Sequential Stages of Muscle Regeneration After Acute Injury in Male Mice
GEO Series GSE261089. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of skeletal muscle model for myotonic dystrophy type 1 (DM1)
GEO Series GSE181895. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing; Other.
microRNA microarray of Sinperca chuatsi's skeletal muscle
GEO Series GSE97173. Siniperca chuatsi; Danio rerio. 6 samples. Type: Non-coding RNA profiling by array.
LSD1 in skeletal muscle
GEO Series GSE230547. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight [plasma proteomics]
Among the physiological consequences of extended spaceflight are loss of skeletal muscle and bone mass. One signaling pathway that plays an important role in maintaining muscle and bone homeostasis is that regulated by the secreted signaling proteins, myostatin (MSTN) and activin A. Here, we used both genetic and pharmacological approaches to investigate the effect of targeting MSTN/activin A signaling in mice that were sent to the International Space Station. Wild type mice lost significant muscle and bone mass during the 33 d spent in microgravity. Muscle weights of Mstn -/- mice, which are about twice those of wild type mice, were largely maintained during spaceflight. Systemic inhibition of MSTN/activin A signaling using a soluble form of the activin type IIB receptor (ACVR2B), which can bind each of these ligands, led to dramatic increases in both muscle and bone mass, with effects being comparable in ground and flight mice. Exposure to microgravity and treatment with the soluble receptor each led to alterations in numerous signaling pathways, which were reflected in changes in levels of key signaling components in the blood as well as their RNA expression levels in muscle and bone. These findings have implications for therapeutic strategies to combat the concomitant muscle and bone loss occurring in people afflicted with disuse atrophy on Earth as well as in astronauts in space, especially during prolonged missions.
Woman skeletal muscle transcriptome with bed rest and countermeasures.
Microgravity has a dramatic impact on human physiology illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group n=8) and the potential beneficial impact of protein supplementation (BRN group n=8) and of a combined resistance and aerobic training (BRE group n=8). Gene expression profiles were obtained using an in-house made microarray containing 6681 muscles-relevant genes. A two-class statistical analysis was applied on the 2103 genes with consolidated expression. We identified 472 and 207 modified genes respectively for SOL and VL in BRC group. Further clustering approaches identifying relevant biological mechanisms or pathways underlined five main subclusters. Three are composed almost of upregulated genes involved mainly in nucleic acid and protein metabolism and two composed almost of downregulated genes involved in energy metabolism. Exercise countermeasure demonstrated a drastic compensatory effect decreasing the number of differentially-expressed genes by 89 and 96% in SOL and VL. In contrast nutrition countermeasure had a moderate effect and decreased the number of differentially-expressed genes by 40 and 25% in SOL and VL. Our results allowed reporting a systematic global and comprehensive view of long-term woman muscle atrophy and brought new lights and insights for space environment and for women who undergo a long-term clinical bed rest. Biological samples were collected from Pre- and Post- bed rest (BR) soleus and vastus lateralis biopsies of each subject from the three groups (bed rest only: BRC; Exercise: BRE; Nutrition: BRN). six technical replicate values (2 duplicate hybridizations a et b to chips with triplicate spots xxx) were obtained for each skeletal muscle sample. Thus for each subject 12 expression measurements (6 before BR and 6 after BR) were obtained for each muscle.
Effects of spaceflight on murine skeletal muscle gene expression
Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and shifts towards faster muscle fiber types. To identify changes in gene expression that may underlie these adaptations, microarray expression analysis was performed on gastrocnemius from mice flown on the STS-108 shuttle flight (11 days, 19 hours) versus mice maintained on earth for the same period. Additionally, to identify changes that were due to unloading and reloading, microarray analyses were conducted on calf muscle from ground-based mice subjected to hindlimb suspension (12 days) and mice subjected to hindlimb suspension plus a brief period of reloading (3.5 hours) to simulate the time between landing and sacrifice of the spaceflight mice.
Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight from RR-1 and RR-9 (calcium uptake and Western blot in soleus and tibialis anterior)
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss in muscle force and size with the loss in muscle force occurring at a faster rate. Although the exact mechanisms are unknown, a role for Ca2+ dysregulation has been suggested. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump actively brings cytosolic Ca2+ into the SR, eliciting muscle relaxation and maintaining low intracellular Ca2+ ([Ca2+]i). SERCA dysfunction contributes to elevations in [Ca2+]i, leading to cellular damage, and may contribute to the muscle weakness and atrophy observed with spaceflight. Here, we investigated SERCA function, SERCA regulatory protein content, and reactive oxygen/nitrogen species (RONS) protein adduction in murine skeletal muscle after 35-37 days of spaceflight. In male and female soleus muscles, spaceflight led to drastic impairments in Ca2+ uptake despite significant increases in SERCA1a protein content. We attribute this impairment to an increase in RONS production and elevated total protein tyrosine (T) nitration and cysteine (S) nitrosylation. Contrarily, in the tibialis anterior (TA), we observed an enhancement in Ca2+ uptake, which we attribute to a shift towards a faster muscle fiber type (i.e., increased myosin heavy chain IIb and SERCA1a) without elevated total protein T-nitration and S-nitrosylation. Thus, spaceflight affects SERCA function differently between the soleus and TA. This dataset derives results from the calcium uptake (spectrofluorometry) and Western blot assays.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.