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4,469 results for “Elderly;”
Data from: Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan
Objective: The aim of this study is to estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. Methods: A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed-up prospectively for 17 years. The cumulative incidence of dementia was estimated based on a death- and dementia-free survival function and the hazard functions of dementia at each year, which were computed by using a Weibull proportional hazards model. The lifetime risk of dementia was defined as the cumulative incidence of dementia at the point in time when the survival probability of the population was estimated to be less than 0.5%. Results: During the follow-up, 350 subjects experienced some type of dementia; among them, 191 subjects developed Alzheimer's disease (AD) and 117 developed vascular dementia (VaD). The lifetime risk of dementia was 55% (95% confidence interval [CI], 49-60%). Women had an approximately 1.5-time greater lifetime risk of dementia than men (65% [57-72%] vs. 41% [33-49%]). The lifetime risks of developing AD and VaD were 42% (35-50%) and 16% (12-21%) in women, versus 20% (7-34%) and 18% (13-23%) in men, respectively. Conclusion: Lifetime risk of all dementia for Japanese elderly was substantial at approximately 50% or higher. This study suggests that the lifetime burden attributable to dementia in contemporary Japanese communities is immense.
Data from: Daridorexant, a new dual orexin receptor antagonist in elderly subjects with insomnia disorder: a randomized clinical trial
<p><b>Objective:</b> To assess the dose-response of daridorexant, a new dual orexin receptor antagonist, on wake after sleep onset (WASO).</p> <p><b>Methods:</b> Elderly (≥65 years) subjects (n = 58) with insomnia were randomly allocated (Latin square design) to receive five treatments (5, 10, 25, and 50 mg daridorexant and placebo) during five treatment periods, each consisting of two treatment nights followed by a 5–12-day washout period. Main efficacy endpoints were the absolute change from baseline in WASO (primary) and latency to persistent sleep (LPS; secondary) to Days 1&2 (mean of two treatment nights assessed by polysomnography) in each period. Safety and tolerability were also assessed.</p> <p><b>Results:</b> Of 58 subjects included, 67% were female and median age was 69 years [range 65–85]). WASO and LPS were dose-dependently reduced from baseline to Days 1&2 following daridorexant administration (multiple comparison procedure-modeling, p<0.0001 and p=0.004, respectively); reductions were statistically significant for doses 10 mg and above compared with placebo (WASO: –32.0, –45.1, –61.4 min; LPS: –44.9, –43.8, –45.4 min; for 10, 25, and 50 mg, respectively, p≤0.025). Treatment-emergent adverse events were similar for daridorexant and placebo; the most frequent were fatigue, nasopharyngitis, gait disturbance, and headache (≤7% in any group).</p> <p><b>Conclusions:</b> Daridorexant was well tolerated. Dose-dependent improvements in WASO and LPS were statistically significant (dose range 10–50 mg) in elderly subjects with insomnia disorder. ClinicalTrials.gov (NCT02841709).</p> <p><b>Classification of Evidence:</b> This study provides Class III evidence that for elderly subjects with insomnia, daridorexant reduced wake after sleep onset time.</p>
Data from: Epidemiological survey of the feasibility of broadband ultrasound attenuation measured using calcaneal quantitative ultrasound to predict the incidence of falls in the middle aged and elderly
Objectives: We investigated whether calcaneal quantitative ultrasound (QUS-C) is a feasible tool for predicting the incidence of falls. Design: Prospective epidemiological cohort study. Setting: Community-dwelling people sampled in central western Taiwan. Participants: A cohort of community-dwelling people who were ≥40 years old (men: 524; women: 676) in 2009–2010. Follow-up questionnaires were completed by 186 men and 257 women in 2012. Methods: Structured questionnaires and broadband ultrasound attenuation (BUA) data were obtained in 2009–2010 using QUS-C, and follow-up surveys were done in a telephone interview in 2012. Using a binary logistic regression model, the risk factors associated with a new fall during follow-up were analysed with all significant variables from the bivariate comparisons and theoretically important variables. Primary outcome measures: The incidence of falls was determined when the first new fall occurred during the follow-up period. The mean follow-up time was 2.83 years. Results: The total incidence of falls was 28.0 per 1000 person-years for the ≥40 year old group (all participants), 23.3 per 1000 person-years for the 40–70 year old group, and 45.6 per 1000 person-years for the ≥70 year old group. Using multiple logistic regression models, the independent factors were current smoking, living alone, psychiatric drug usage and lower BUA (OR 0.93; 95% CI 0.88 to 0.99, p<0.05) in the ≥70 year old group. Conclusions: The incidence of falls was highest in the ≥70 year old group. Using QUS-C-derived BUA is feasible for predicting the incidence of falls in community-dwelling elderly people aged ≥70 years.
Self-Motion Perception in the Elderly
<p>Self-motion through space generates a visual pattern called optic flow. It can be used to determine one’s direction of self-motion (heading). Previous studies have already shown that this perceptual ability, which is of critical importance during everyday life, changes with age. In most of these studies subjects were asked to judge whether they appeared to be heading to the left or right of a target. Thresholds were found to increase continuously with age. In our current study, we were interested in absolute rather than relative heading judgements and in the question about a potential neural correlate of an age-related deterioration of heading perception. Two groups, older test subjects and younger controls, were shown optic flow stimuli in a virtual-reality setup. Visual stimuli simulated self-motion through a 3-D cloud of dots and subjects had to indicate their perceived heading direction after each trial. In different subsets of experiments we varied individually relevant stimulus parameters: presentation time, number of dots in the display, stereoscopic vs. non-stereoscopic stimulation, and motion coherence. We found decrements in heading performance with age for each stimulus parameter. In a final step we aimed to determine a putative neural basis of this behavioural decline. To this end we modified a neural network model which previously has proven to be capable of reproduce and predict certain aspects of heading perception. We show that the observed data can be modeled by implementing an age related neuronal cell loss in this neural network. We conclude that a continuous decline of certain aspects of motion perception, among them heading, might directly be based on an age-related progressive loss of groups of neurons being activated by visual motion. </p>
Dataset for "Projected thermally driven elderly mortality for Beijing under greenhouse gas and stratospheric aerosol geoengineering scenarios"
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raw data - Effects of preemptive acupuncture on cognitive function of the elderly patients after hip replacement: a randomized controlled trial
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raw data - Estimated Pulse Wave Velocity and Osteoporosis in the Middle-aged and Elderly Population: An analysis from NHANES 2005-2020
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Supplementary material 6 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 6
Supplementary material 5 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 5
Supplementary material 9 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 9
Supplementary material 2 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 2
Supplementary material 4 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 4
Supplementary material 8 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 8
Supplementary material 1 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 1
Supplementary material 3 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 3
Supplementary material 7 from: Stanley CH, Hecht R, Cakir S, Brzoska P (2022) Approach to user group-specific assessment of urban green spaces for a more equitable supply exemplified by the elderly population. One Ecosystem 7: e83325. https://doi.org/10.3897/oneeco.7.e83325
Supplementary material 7
Profile of caregivers of elderly people treated at a Geriatrics and Neurogeriatrics outpatient clinic
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Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for interventional clinical trial)
<p>Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel insights and clinical value can be derived. Here we present novel, digital mobility data from two studies: an independent, non-interventional validation study with elderly, naturally slow walking subjects, and a global, multi-site phase IIb clinical trial involving patients with age-related muscle loss and slow walking speed (sarcopenia). Based on these data, we validate the accuracy of a novel algorithm for capturing in-clinic and real-world gait speed in frail, slow-walking adults. We demonstrate the feasibility of continuous monitoring with a wearable inertial sensor in elderly adults in real-world settings, and propose minimum thresholds for compliance required for robust capture of gait behaviors in this population. We also show how simple, inferred contextual information, describing the length of a given walking bout, can explain some of the variation in real-world gait speed, and use this information to demonstrate for the first time a relationship between in-clinic performance and real-world gait speed behavior. This work lays a foundation for exploration of the clinical relevance and value of such measures and is a first step in building a more complete chain of evidence between standardized physical performance assessment, real-world behavior, and subjective perceptions of mobility, independence and health.</p> <p>This dataset contains data collected during the interventional clinical trial: derived data from raw accelerometry data, and summary performance data.</p> <p>The full dataset, including raw accelerometry data, is available here: <a href="https://mueller-et-al-2019.s3.amazonaws.com/index.html">https://mueller-et-al-2019.s3.amazonaws.com/index.html</a></p>
Can rural elderly groups be supported by increasing the pension contribution rate?
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Relationship between Cognitive Function, Fear of Falling, and Balance in Community-Dwelling Elderly: Cross-Sectional Study.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.