Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
7,228
datasets available to search
ShareScore release 0.9.0
Dataset results
7,228 results for “Modules”
Data from: High throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes
Trichloroethylene (TCE), an industrial chemical and environmental contaminant, is a human carcinogen. Reactive metabolites are implicated in renal carcinogenesis associated with TCE exposure, yet the toxicity mechanisms of these metabolites and their contribution to cancer and other adverse effects remain unclear. We employed an integrated functional genomics approach that combined functional profiling studies in yeast and avian DT40 cell models to provide new insights into the specific mechanisms contributing to toxicity associated with TCE metabolites. Genome-wide profiling studies in yeast identified the error-prone translesion synthesis pathway as an import mechanism in response to TCE metabolites. The role of translesion synthesis DNA repair was further confirmed by functional profiling in DT40 avian cell lines, but also revealed that translesion synthesis and homologous recombination DNA repair likely play competing roles in cellular susceptibility to TCE metabolites in higher eukaryotes. These DNA repair pathways are highly conserved between yeast, DT40, and humans. We propose that in humans, mutagenic translesion synthesis is favored over homologous recombination repair in response to TCE metabolites. The results of these studies contribute to the body of evidence supporting a mutagenic mode of action for TCE-induced renal carcinogenesis mediated by reactive metabolites in humans. Our approach illustrates the potential for high-throughput in vitro functional profiling in yeast to elucidate toxicity pathways (molecular initiating events, key events) and candidate susceptibility genes for focused study.
Data from: Strategic exploitation of fluctuating asymmetry in male Endler's guppy courtship displays is modulated by social environment
Lateral asymmetry in signalling traits enables males to strategically exploit their best side. In many animals, both body colouration and fluctuating asymmetry are signals of male attractiveness. We demonstrated experimentally that even sexually naïve male Poecilia wingei were able to identify their most attractive side (i.e. that with a higher proportion of carotenoid pigmentation) and use it preferentially during courtship. Notably, males retained their strategic signalling in a male-biased social environment, whereas they ceased to signal strategically in a female-biased environment. The degree of asymmetry in colouration did not affect overall courtship activity. Strategic lateralization in courtship displays was strongest and most repeatable in the male-biased social environment where males competed with rivals for matings. Individual asymmetry in colouration changed considerably over a period of 3 months. This suggests that colouration is a dynamic feature during adulthood and that males are capable of tracking and strategically exploiting their lateral asymmetry in accordance with their social environment.
Data from: ACC deaminase-producing rhizosphere bacteria modulate plant responses to flooding
Flooding events are predicted to increase over the coming decades, calling for a better understanding of plant responses to submergence. Specific root-associated microbes alter plant hormonal balance, affecting plant growth and stress tolerance. We hypothesized that the presence of such microbes may modulate plant responses to submergence. We tested whether root-associated bacteria producing the enzyme ACC (1-aminocyclopropane-1-carboxylate) deaminase affect submergence responses in Rumex palustris, a flood tolerant riparian plant. Ethylene is a key plant hormone regulating flood–associated acclimations and ACC deaminase activity of bacteria may decrease ethylene levels in the plant. Rumex palustris plants were inoculated with Pseudomonas putida UW4 or an isogenic mutant lacking ACC deaminase, and subsequently exposed to complete submergence. Submergence triggered ethylene-mediated responses, including an increase in leaf elongation and shoot fresh weight. Flood responses, including post-submergence ethylene production, were reduced in plants inoculated with ACC deaminase-producing wild type bacteria, as compared to plants inoculated with the ACC deaminase negative mutant. Synthesis. We demonstrate that root-associated bacteria can alter plant response to environmental stress by altering plant hormonal balance. Plant-microbes interactions may thus be an overseen driver of plant life history strategies that should be taken into account when assessing plant ecological adaptations such as abiotic stress resistance.
Data from: Spectral and temporal acoustic features modulate response irregularities within primary auditory cortex columns
Assemblies of vertically connected neurons in the cerebral cortex form information processing units (columns) that participate in the distribution and segregation of sensory signals. Despite well-accepted models of columnar architecture, functional mechanisms of inter-laminar communication remain poorly understood. Hence, the purpose of the present investigation was to examine the effects of sensory information features on columnar response properties. Using acute recording techniques, extracellular response activity was collected from the right hemisphere of eight mature cats (felis catus). Recordings were conducted with multichannel electrodes that permitted the simultaneous acquisition of neuronal activity within primary auditory cortex columns. Neuronal responses to simple (pure tones), complex (noise burst and frequency modulated sweeps), and ecologically relevant (con-specific vocalizations) acoustic signals were measured. Collectively, the present investigation demonstrates that despite consistencies in neuronal tuning (characteristic frequency), irregularities in discharge activity between neurons of individual A1 columns increase as a function of spectral (signal complexity) and temporal (duration) acoustic variations.
Data from: Age-dependent modulation of songbird summer feather molt by temporal and functional constraints
Time constraints influence various ecological, life-history, and demographic properties of individuals and populations of many species throughout the annual cycle. Feather molt is a timely undertaking that is considered among the three most energy-demanding processes in the life cycle of birds. To deal with time pressure, passerines may shorten their molt duration, using three non–mutually exclusive mechanisms: (1) replacing only part of the plumage, (2) increasing the speed of molt, and (3) postponing the renewal of some or all the plumage to a later season (i.e., from the summer to the overwintering period). We used a comparative approach by measuring 12,349 individuals from 134 passerine species to explore how feather molt of juvenile and adult passerines is evolutionarily modulated under time constraints. The results indicate that breeding at northern latitudes and long-distance migration limit the time available for molt and that the consequences of time constraints were age dependent. While the duration of adult summer molt decreased, the extent, rather than the duration, of juvenile molt declined under time constraints. This study highlights the importance of considering time constraints in order to enhance the understanding of selective forces that shape life-history processes and their consequences throughout the annual routine.
Data from: Opposite distortions in interval timing perception for visual and auditory stimuli with temporal modulations
When an object is presented visually and moves or flickers, the perception of its duration tends to be overestimated. Such an overestimation is called time dilation. Perceived time can also be distorted when a stimulus is presented aurally as an auditory flutter, but the mechanisms and their relationship to visual processing remains unclear. In the present study, we measured interval timing perception while modulating the temporal characteristics of visual and auditory stimuli, and investigated whether the interval times of visually and aurally presented objects shared a common mechanism. In these experiments, participants compared the durations of flickering or fluttering stimuli to standard stimuli, which were presented continuously. Perceived durations for auditory flutters were underestimated, while perceived durations of visual flickers were overestimated. When auditory flutters and visual flickers were presented simultaneously, these distortion effects were cancelled out. When auditory flutters were presented with a constantly presented visual stimulus, the interval timing perception of the visual stimulus was affected by the auditory flutters. These results indicate that interval timing perception is governed by independent mechanisms for visual and auditory processing, and that there are some interactions between the two processing systems.
Data from: Functional divergence of the nuclear receptor NR2C1 as a modulator of pluripotentiality during hominid evolution
Genes encoding nuclear receptors (NRs) are attractive as candidates for investigating the evolution of gene regulation because they (1) have a direct effect on gene expression and (2) modulate many cellular processes that underlie development. We employed a three-phase investigation linking NR molecular evolution among primates with direct experimental assessment of NR function. Phase 1 was an analysis of NR domain evolution and the results were used to guide the design of phase 2, a codon-model-based survey for alterations of natural selection within the hominids. By using a series of reliability and robustness analyses we selected a single gene, NR2C1, as the best candidate for experimental assessment. We carried out assays to determine whether changes between the ancestral and extant NR2C1s could have impacted stem cell pluripotency (phase 3). We evaluated human, chimpanzee, and ancestral NR2C1 for transcriptional modulation of Oct4 and Nanog (key regulators of pluripotency and cell lineage commitment), promoter activity for Pepck (a proxy for differentiation in numerous cell types), and average size of embryological stem cell colonies (a proxy for the self-renewal capacity of pluripotent cells). Results supported the signal for alteration of natural selection identified in phase 2. We suggest that adaptive evolution of gene regulation has impacted several aspects of pluripotentiality within primates. Our study illustrates that the combination of targeted evolutionary surveys and experimental analysis is an effective strategy for investigating the evolution of gene regulation with respect to developmental phenotypes.
Data from: Quantitative trait loci from the host genetic background modulate the durability of a resistance gene: a rational basis for sustainable resistance breeding in plants
The combination of major resistance genes with quantitative resistance factors is hypothesized as a promising breeding strategy to preserve the durability of resistant cultivar, as recently observed in different pathosystems. Using the pepper (Capsicum annuum)/Potato virus Y (PVY, genus Potyvirus) pathosystem, we aimed at identifying plant genetic factors directly affecting the frequency of virus adaptation to the major resistance gene pvr23 and at comparing them with genetic factors affecting quantitative resistance. The resistance breakdown frequency was a highly heritable trait (h²=0.87). Four loci including additive quantitative trait loci (QTLs) and epistatic interactions explained together 70% of the variance of pvr23 breakdown frequency. Three of the four QTLs controlling pvr23 breakdown frequency were also involved in quantitative resistance, strongly suggesting that QTLs controlling quantitative resistance have a pleiotropic effect on the durability of the major resistance gene. With the first mapping of QTLs directly affecting resistance durability, this study provides a rationale for sustainable resistance breeding. Surprisingly, a genetic trade-off was observed between the durability of PVY resistance controlled by pvr23 and the spectrum of the resistance against different potyviruses. This trade-off seemed to have been resolved by the combination of minor-effect durability QTLs under long term farmer selection.
Dataset for Social context modulates idiosyncrasy of behaviour in the gregarious cockroach Blaberus discoidalis
<p>Individuals are different, but they can work together to perform adaptive collective behaviours. Despite emerging evidence that individual variation strongly affects group performance, it is less clear to what extent individual variation is modulated by participation in collective behaviour. We examined light avoidance (negative phototaxis) in the gregarious cockroach Blaberus discoidalis, in both solitary and group contexts. Cockroaches in groups exhibit idiosyncratic light-avoidance performance that persists across days, with some individual cockroaches avoiding a light stimulus 75% of the time, and others avoiding the light just above chance (i.e. ~50% of the time). These individual differences are robust to group composition. Surprisingly, these differences do not persist when individuals are tested in isolation, but return when testing is once again done with groups. During the solo testing phase cockroaches exhibited individually consistent light-avoidance tendencies, but these differences were uncorrelated with performance in any group context. Therefore, we have observed not only that individual variation affects group-level performance, but also that whether or not a task is performed collectively can have a significant, predictable effect on how an individual behaves. That individual behavioural variation is modulated by whether a task is performed collectively has major implications for understanding variation in behaviours that are facultatively social, and it is essential that ethologists consider social context when evaluating individual behavioural differences.</p>
Compact Markov-modulated models for multiclass trace fitting
<p>This is the dataset used in the paper "Compact Markov-modulated models for multiclass trace fitting" by G. Casale, A. Sansottera, P. Cremonesi to appear in European Journal of Operational Research. Please check the README.TXT file for details on the dataset. </p>
Modeling of the SEA complex, a modulator of the TORC1 pathway
<p>These scripts demonstrate the use of IMP, MODELLER, and PMI in the modeling of the SEA complex using 188 DSS chemical cross-links and 23 composites from affinity purification.</p> <p>First, MODELLER is used to generate initial structures for the individual components where reliable templates are available. Then, IMP / PMI are used to model these components using the DSS crosslinks and the affinity purification data for the entire SEA complex.</p> <p>For more information about how to reproduce this modeling, see https://salilab.org/sea or the README file.</p>
Figure 3 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 3 A. Stress (and its many sensory inputs) activates different areas in the brain – the prefrontal cortex (PFC), the thalamus (Thal), the limbic system (LS, comprising the amygdala, hippocampus and hypothalamus), with subsequent adverse effects for the whole organism: fear‐related behaviour, depressive-like conditions, anxiety, helplessness and hopelessness, sleep and feeding disorders; B. Endocannabinoids modulate the activity of pyramidal glutamate neurons and prefrontal glutamatergic plasticity, and have been proved beneficial in decreasing anxiety and depressive-like symptoms, alleviation of fear-conditioned memories, improvement of sleep and feeding.
Figure 2 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 2 Effects on r-SIA (1 h RS) estimated by PP-test after A. Clonidine (Clo); B. Desipramine (Des); and C. Yohimbine (Yoh) administrations alone or in combination with anandamide (AEA) / AM251 (AM). Mean values ± S.E.M. are presented in arbitrary units (AU) on the 10th, 20th, 30th, and 40th min after substances administration. A–C ***p < 0.001 vs. controls; +++p < 0.001vs. 1 h RS; xxxp < 0.001vs. A. 1 h RS+Clo; B. 1 h RS+Des; C. 1 h RS+Yoh; xp < 0.05 vs. B. 1 h RS+Des; $$$p < 0.001vs. A. 1 h RS+Clo+AEA; B. 1 h RS+Des+AEA; C. 1 h RS+Yoh+AEA; $p < 0.05 vs. C. 1 h RS+Yoh+AEA.
Figure 1 from: Suleymanoglu Y, Bakalov D, Sabit Z, Vodenicharov V, Tafradjiiska-Hadjiolova R, Nocheva H (2024) The endogenous cannabinoid and the adrenergic systems in modulation of stress-response. Pharmacia 71: 1-8. https://doi.org/10.3897/pharmacia.71.e115659
Figure 1 Effects of AEA on r-SIA estimated by PP-test after one hour of restraint (1 h RS) in rats. Mean values ± S.E.M. are presented in arbitrary units (AU) on the 10th, 20th, 30th, and 40th min after substances administration. ***p < 0.001 vs. controls; +++p < 0.001vs. RS.
Research data for "Tidal modulation of the seismic activity related to the 2021 La Palma volcanic eruption"
<p>Research data for <br> <br> Tidal modulation of the seismic activity related to the 2021 La Palma volcanic eruption</p> <p>Luis Miguelsanz (1), José Fernández (1), Juan F.Prieto (2), Kristy F. Tiampo (3)</p> <p>(1) Institute of Geosciences (IGEO), CSIC-UCM, Calle del Doctor Severo Ochoa, 7. 28040-Madrid, Spain.<br> (2) E.T.S. de Ingenieros en Topografía, Geodesia y Cartografía, Universidad Politécnica de Madrid, 28031-Madrid, Spain.<br> (3) Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder, Boulder, CO, USA.</p> <p> <br> </p> <p><br> Introduction</p> <p>This set of files contains data supporting the tables and figures featured in the journal article.<br> <br> File Ts01.xlsx shows earthquake data belonging to the Phase 0 defined in the manuscript, as well as tidal stress phases and amplitudes obtained for each event using the methodology explained in the text. <br> Files Ts02.xlsx and Ts03.xlsx are datasets analog to File Ts01.xlsx, but using data corresponding to Phase 1 and Phase 2 respectively. <br> Data of Files Ts01.xlsx, Ts02.xlsx and Ts03.xlsx have been used to compose Tables 1, 2, 3, 4, and Figures 3, 4, 5, 6, 7.</p> <p>File Ts04.xlsx features tidal strain values (Volume strain and East-West, North-South and Vertical components) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the <br> geographical center of all the epicenters of the catalogue, and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25.<br> Data from File Ts04.xlsx has been used for composition of Figures 9 and 10 in the manuscript.</p> <p>File Ts05.xlsx features tidal stress values (East-West, North-South and Vertical components) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center <br> of all the epicenters of the catalogue, and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25. <br> Data from File Ts05.xlsx has been used for composition of Figure 11 in the manuscript.</p> <p>File Ts06.xlsx features tidal stress values (ocean-loading tides and body tides) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all the <br> epicenters of the catalogue, and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25. <br> Data from File Ts06.xlsx has been used for composition of Figure 12 in the manuscript.</p> <p>File Ts07.xlsx shows tidal tilt phases and amplitudes obtained for each event in the three Phases 0, 1, and 2 (North-South and East-West components).<br> Data from File Ts07.xlsx has been used for composition of Figures 13 and 14 and Tables 5 and 6 in the manuscript.</p> <p>File Ts08.xlsx features tidal tilt values (North-South and East-West components) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all <br> the epicenters of the catalogue during the period 2021/08/31 – 2021/12/25. <br> Data from File Ts08.xlsx has been used for composition of Figure 15 in the manuscript. </p> <p>File Ts09.xlsx shows tidal stress phases and amplitudes calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all the epicenters of the catalogue, <br> and whose depth is the mean depth of the events in the catalogue throughout the year 2021.<br> Data from File Ts09.xlsx has been used for the discussion in chapter 5 about the predominance of ocean-loading tides over solid earth tides.</p> <p>1. Ts01.xlsx Data used to detect tidal stress correlations in Phase 0 of the volcanic crisis.</p> <p>1.1 Column "Year", y.<br> 1.2 Column "Month", m.<br> 1.3 Column "Day", d.<br> 1.4 Column "Hour", h.<br> 1.5 Column "Minute", min.<br> 1.6 Column "Second", s.<br> 1.7 Column "Latitude", deg, latitude north of equator.<br> 1.8 Column "Longitude", deg, longitude east of Greenwich.<br> 1.9 Column "Depth", km.<br> 1.10 Column "Phase_confining_stress", deg, tidal phase angle assigned to the event, calculated for tidal confining stress.<br> 1.11 Column "Amplitude_confining_stress", Pa, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress.<br> 1.12 Column "Phase_confining_stress_rate", deg, tidal phase angle assigned to the event, calculated for tidal confining stress rate.<br> 1.13 Column "Amplitude_confining_stress_rate", Pa/h, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress rate.<br> 1.14 Column "Magnitude", earthquake magnitude.</p> <p><br> 2. Ts02.xlsx Data used to detect tidal stress correlations in Phase 1 of the volcanic crisis.</p> <p>2.1 Column "Year", y.<br> 2.2 Column "Month", m.<br> 2.3 Column "Day", d.<br> 2.4 Column "Hour", h.<br> 2.5 Column "Minute", min.<br> 2.6 Column "Second", s.<br> 2.7 Column "Latitude", deg, latitude north of equator.<br> 2.8 Column "Longitude", deg, longitude east of Greenwich.<br> 2.9 Column "Depth", km.<br> 2.10 Column "Phase_confining_stress", deg, tidal phase angle assigned to the event, calculated for tidal confining stress.<br> 2.11 Column "Amplitude_confining_stress", Pa, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress.<br> 2.12 Column "Phase_confining_stress_rate", deg, tidal phase angle assigned to the event, calculated for tidal confining stress rate.<br> 2.13 Column "Amplitude_confining_stress_rate", Pa/h, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress rate.<br> 2.14 Column "Magnitude", earthquake magnitude.<br> 2.15 Column "Autonum", autonumeric code.</p> <p><br> 3. Ts03.xlsx Data used to detect tidal stress correlations in Phase 2 of the volcanic crisis.</p> <p>3.1 Column "Year", y.<br> 3.2 Column "Month", m.<br> 3.3 Column "Day", d.<br> 3.4 Column "Hour", h.<br> 3.5 Column "Minute", min.<br> 3.6 Column "Second", s.<br> 3.7 Column "Latitude", deg, latitude north of equator.<br> 3.8 Column "Longitude", deg, longitude east of Greenwich.<br> 3.9 Column "Depth", km.<br> 3.10 Column "Phase_confining_stress", deg, tidal phase angle assigned to the event, calculated for tidal confining stress.<br> 3.11 Column "Amplitude_confining_stress", Pa, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress.<br> 3.12 Column "Phase_confining_stress_rate", deg, tidal phase angle assigned to the event, calculated for tidal confining stress rate.<br> 3.13 Column "Amplitude_confining_stress_rate", Pa/h, amplitude of the tidal half cycle in which the event occurs, calculated for tidal confining stress rate.<br> 3.14 Column "Magnitude", earthquake magnitude.<br> 3.15 Column "Autonum", autonumeric code.</p> <p><br> 4. Ts04.xlsx Tidal strain calculated at two-hour intervals for for an imaginary focus whose epicenter is set at the geographical center of all the epicenters of the catalogue, <br> and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25.</p> <p>4.1 Column "Latitude", deg, latitude north of equator.<br> 4.2 Column "Longitude", deg, longitude east of Greenwich.<br> 4.3 Column "Depth", km.<br> 4.4 Column "Date", date in format yyyymmdd.<br> 4.5 Column "Time", time in format hour : minute : second.<br> 4.6 Column "Volume strain", nanostrain, tidal volume strain.<br> 4.7 Column "East-West strain", nanostrain, tidal East-West strain.<br> 4.8 Column "North-South strain", nanostrain, tidal North-South strain.<br> 4.9 Column "Vertical strain", nanostrain, tidal Vertical strain.</p> <p><br> 5. Ts05.xlsx Tidal stress calculated at two-hour intervals for for an imaginary focus whose epicenter is set at the geographical center of all the epicenters of the catalogue, <br> and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25.</p> <p>5.1 Column "Latitude", deg, latitude north of equator.<br> 5.2 Column "Longitude", deg, longitude east of Greenwich.<br> 5.3 Column "Depth", km.<br> 5.4 Column "Date", date in format yyyymmdd.<br> 5.5 Column "Time", time in format hour : minute : second.<br> 5.6 Column "East-West stress", Pa, tidal East-West stress.<br> 5.7 Column "North-South stress", Pa, tidal North-South stress.<br> 5.8 Column "Vertical stress", Pa, tidal Vertical stress.</p> <p><br> 6. Ts06.xlsx tidal stress (ocean-loading tides and body tides) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all <br> the epicenters of the catalogue, and whose depth is the mean depth of the events in the catalogue during the period 2021/08/31 – 2021/12/25. </p> <p>6.1 Column "Latitude", deg, latitude north of equator.<br> 6.2 Column "Longitude", deg, longitude east of Greenwich.<br> 6.3 Column "Depth", km.<br> 6.4 Column "Date", date in format yyyymmdd.<br> 6.5 Column "Time", time in format hour : minute : second.<br> 6.6 Column "Ocean tides stress", Pa, tidal stress due to ocean-loading tides.<br> 6.7 Column "Body tides stress", Pa, tidal stress due to body tides.</p> <p><br> 7. Ts07.xlsx Tidal tilt phases and amplitudes for the events in the three Phases 0, 1, and 2.</p> <p>7.1 Column "Phase", number of the phase of the seismic unrest, as defined in the manuscript (0, 1, and 2).<br> 7.2 Column "Year", y.<br> 7.3 Column "Month", m.<br> 7.4 Column "Day", d.<br> 7.5 Column "Hour", h.<br> 7.6 Column "Minute", min.<br> 7.7 Column "Second", s.<br> 7.8 Column "Latitude", deg, latitude north of equator.<br> 7.9 Column "Longitude", deg, longitude east of Greenwich.<br> 7.10 Column "Depth", km.<br> 7.11 Column "Phase_tilt_NS", deg, tidal phase angle assigned to the event, calculated for tidal tilt (North-South component).<br> 7.12 Column "Ampl_tilt_NS", nrad, amplitude of the tidal half cycle in which the event occurs, calculated for tidal tilt (North-South component).<br> 7.13 Column "Phase_tilt_EW", deg, tidal phase angle assigned to the event, calculated for tidal tilt (East-West component).<br> 7.14 Column "Ampl_tilt_NS", nrad, amplitude of the tidal half cycle in which the event occurs, calculated for tidal tilt (East-West component).<br> 7.15 Column "Magnitude", earthquake magnitude.</p> <p><br> 8. Ts08.xlsx Tidal tilt (North-South and East-West components) calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all <br> the epicenters of the catalogue during the period 2021/08/31 – 2021/12/25. </p> <p>8.1 Column "Latitude", deg, latitude north of equator.<br> 8.2 Column "Longitude", deg, longitude east of Greenwich.<br> 8.3 Column "Depth", km.<br> 8.4 Column "Date", date in format yyyymmdd.<br> 8.5 Column "Time", time in format hour : minute : second.<br> 8.6 Column "East-West tilt", nrad, East-West tidal tilt.<br> 8.7 Column "North-South tilt", nrad, North-South tidal tilt.</p> <p><br> 9. Ts09.xlsx tidal stress phases and amplitudes calculated at two-hour intervals for an imaginary focus whose epicenter is set at the geographical center of all <br> the epicenters of the catalogue, and whose depth is the mean depth of the events in the catalogue throughout the year 2021.<br> 9.1 Column "Latitude", deg, latitude north of equator.<br> 9.2 Column "Longitude", deg, longitude east of Greenwich.<br> 9.3 Column "Depth", km.<br> 9.4 Column "Date", date in format yyyymmdd.<br> 9.5 Column "Time", time in format hour : minute : second.<br> 9.6 Column "Phase (body tides)", degrees, tidal stress phase angle calculated for body tides.<br> 9.7 Column "Amplitude (body tides)", Pa, amplitude of the tidal half cycle, calculated for body tides.<br> 9.8 Column "Phase (ocean tides)", degrees, tidal stress phase angle calculated for ocean-loading tides.<br> 9.9 Column "Amplitude (ocean tides)", Pa, amplitude of the tidal half cycle, calculated for ocean-loading tides.</p>
Raw data for the article: 3D Culture and Interferon-? Priming Modulates Characteristics of Mesenchymal Stromal/Stem Cells by Modifying the Expression of Both Intracellular and Exosomal microRNAs
<p>Mesenchymal stromal/stem cells (MSCs) have emerged as a therapeutic tool in regenerative medicine. Recent studies have shown that exosome (EXO)-derived microRNAs (miRNAs) play a crucial role in mediating MSC functions. Additionally, intracellular miRNAs have been found to regulate MSC therapeutic capacities. However, the molecular mechanisms underlying miRNA-mediated MSC effects are not fully understood. We used 3D culture and IFN-γ to prime/enhance the MSC therapeutic effects in terms of functional miRNAs. After priming, our analysis revealed stable variations in intracellular miRNA among the MSC biological replicates. Conversely, a significant variability of miRNA was observed among EXOs released from biological replicates of the priming treatment. For each priming, we observed distinct miRNA expression profiles between the MSCs and their EXOs. Moreover, in both types of priming, gene ontology (GO) analysis of deregulated miRNAs highlighted their involvement in tissue repair/regeneration pathways. In particular, the 3D culture enhanced angiogenic properties in both MSCs and EXOs, while IFN-γ treatment enriched miRNAs associated with immunomodulatory pathways. These findings suggest that 3D culture and IFN-γ treatment are promising strategies for enhancing the therapeutic potential of MSCs by modulating miRNA expression. Additionally, the identified miRNAs may contribute to understanding the molecular mechanisms underlying the miRNA-mediated therapeutic effects of MSCs.</p>
Model data for "Factors Modulating Variability of Eddy Kinetic Energy in the Southern Ocean from Idealized Simulations" "
<p>This dataset contains the all the idealized simulations with different topographic features.</p>
Effects analysis on energy density optimization and thermal efficiency enhancement of the air-cooled Li-ion battery modules
Open the record for dataset details and reuse information.
Invasive vegetation encroachment modulates dual threats faced by island-endemic scaly crickets
Open the record for dataset details and reuse information.
Dataset for "Time-modulated near-field radiative heat transfer"
<p>Dataset for "Time-modulated near-field radiative heat transfer"</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.