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2,002 results for “sarcoma”
A novel role for the EWS portion of EWS/FLI in binding GGAA-microsatellites required for oncogenic transformation in Ewing sarcoma [ChIP-Seq]
GEO Series GSE94480. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"
<p>This record contains raw data related to article "Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center"</p><p><strong>Abstract</strong></p><p><strong>Introduction:</strong> The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high-volume single center.</p><p><strong>Methods</strong>: Demographic, clinicopathological data on the diagnosis, treatment and follow-up of all sarcoma patients aged 16-39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late-treatment effects.</p><p><strong>Results:</strong> We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate-high-grade, 24% low-grade STSs. Among BS, 32% were high-grade. Median TTD and TTT were 120 (0-8255) and 7 days (0-83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow-up was 72.9 months(1.6-145), 5-year and 10-year OS were 78.5% and 62%, respectively. Kaplan-Meyer analysis showed a significantly better 5-year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5-year OS was 69.8% versus 82.2%, respectively (p = 0.047).</p><p><strong>Conclusion:</strong> Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT.</p><p> </p>
CIC-DUX4 chromatin prolfiling reveals new epigenetic dependencies and actionable therpaeutic targets in CIC-rearranged sarcomas
<p>CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal rearrangements. CIC-DUX4 displays chromatin binding properties, and is therefore believed to function as an aberrant transcription factor. However, the chromatin remodeling events induced by CIC-DUX4 are not well understood, limiting our ability to identify new mechanism-based therapeutic strategies for these patients. Here we generated a genome wide profile of CIC-DUX4 DNA occupancy and associated chromatin states in human CDS cell models and primary tumors. Combining chromatin profiling, proximity ligation assays, as well as genetic and pharmacological perturbations, we show that CIC-DUX4 operates as a potent transcriptional activator at its binding sites. This property is in contrast with the repressive function of the wild type CIC protein, and is mainly mediated through the direct interaction of CIC-DUX4 with the acetyltransferase p300. In keeping with this, we show p300 to be essential for CDS tumor cell proliferation, and its pharmacological inhibition to significantly impact tumor growth in vitro and in vivo. Taken together, our study elucidates the mechanisms underpinning CIC-DUX4-mediated transcriptional regulation and suggests a potential therapeutic approach for the clinical management of CDS patients. </p>
Phase II Study of Ridaforolimus (MK-8669) With Metastatic Bone or Soft-tissue Sarcoma Patients (MK-8669-030 AM1)
ClinicalTrials.gov study NCT01010672. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Multicenter, Single-arm, Prospective Phase II Clinical Study of Epalrotokewali Combined With Eribulin, Anlotinib, and Radiotherapy for the Treatment of Patients With Advanced Soft Tissue Sarcoma.
ClinicalTrials.gov study NCT07205185. IPD Sharing: NO. Countries: 0. Publications: 0.
A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas
ClinicalTrials.gov study NCT00401388. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Outcomes Comparison Between Bone Resection and Subperiosteal Dissection for Specific Type of Soft Tissue Sarcoma
ClinicalTrials.gov study NCT06317480. IPD Sharing: NO. Countries: 0. Publications: 0.
Safety and Effectiveness of an Experimental Drug, IM862, in Treating Kaposi's Sarcoma in AIDS Patients
ClinicalTrials.gov study NCT00002445. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Pegfilgrastim as Support to Pediatric Sarcoma Patients Receiving Chemotherapy
ClinicalTrials.gov study NCT00035620. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Identification of Surgical Management of Lymph Node Basins and Surgical Practice Patterns Among Sarcoma Surgeons
ClinicalTrials.gov study NCT04553744. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Combination Chemotherapy, Radiation Therapy, and Sargramostim Before and After Surgery in Treating Patients With Soft Tissue Sarcoma That Can Be Removed By Surgery
ClinicalTrials.gov study NCT00652860. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Compassionate Use of Aldoxorubicin in Sarcoma Patients Chemotherapy
ClinicalTrials.gov study NCT02570412. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma
ClinicalTrials.gov study NCT00334867. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Paclitaxel in Advanced Refractory Kaposi's Sarcoma (AIDS-KS): A Phase II Trial of Paclitaxel From Baker Norton Pharmaceuticals
ClinicalTrials.gov study NCT00002189. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase 1b/2 Study of AMG 655 With Doxorubicin for the First-Line Treatment of Unresectable Soft Tissue Sarcoma
ClinicalTrials.gov study NCT00626704. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Sarcoma Database at KFSH&RC
ClinicalTrials.gov study NCT01490970. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Surufatinib and Envafolimab as Second or More-line Therapy in Advanced Soft Tissue Sarcoma Patients
ClinicalTrials.gov study NCT05722977. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study to Compare Adjuvant Concurrent Chemoradiation (CCRT) to Adjuvant Radiation Therapy (RT) in Grade 2 and 3 Extremity Soft Tissue Sarcomas
ClinicalTrials.gov study NCT02994264. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study of ZIO-201 in Advanced Sarcoma
ClinicalTrials.gov study NCT00439686. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma
ClinicalTrials.gov study NCT00017160. IPD Sharing: Not stated. Countries: 2. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.